[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597884":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":49,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":85,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University Hospital, Grenoble","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group (LAT)","EXPERIMENTAL","Participants assigned to the experimental group will complete six LAT training sessions at home on a personal computer. Each session lasts approximately five minutes and involves episodic visualizations centered on the self. Repeated exposure across sessions is intended to strengthen memory associations between positive self-related traits and autobiographical experiences.\n\nDuring each session, a series of positive self-referential statements will be displayed on screen. For each statement, participants will be asked to visualize a specific event from their own life that illustrates the quality described. This exercise is designed to generate vivid, self-relevant mental imagery linked to various personal strengths and attributes.",[13],"Other: The Lexical Association Technique (LAT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Active Control Group","ACTIVE_COMPARATOR","Participants in the active control group will also complete six training sessions at home on a personal computer. The structure and timing of the sessions will be identical to those in the experimental condition. However, the statements presented will refer to others (e.g., pharmacists, teachers, animals...) rather than the self, while maintaining the same positive tone and format as the LAT items.\n\nAs in the experimental group, participants will be asked to visualize a positive event corresponding to each statement.\n\nThis control condition enables researchers to isolate the specific effect of self-referential content while preserving key task features such as episodic imagery, emotional valence, cognitive effort, duration, and computer-based delivery.",[19],"Other: Placebo of the Lexical Association Technique",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"The Lexical Association Technique (LAT)","The Lexical Association Technique (LAT) was developed by Niveau, New, and Beaudoin in 2021 (Niveau et al., 2022). It is grounded in principles of memory functioning described in the cognitive psychology literature, particularly the theoretical framework of the Self-Memory System proposed by Conway (2000, 2005).\n\nThe technique aims to enhance self-esteem by strengthening associative links between the self and positively valenced concepts stored in memory. To achieve this, it relies on the repeated mental visualization of positive autobiographical episodes paired with positive self-referential linguistic statements.\n\nThe effectiveness of this technique in increasing self-esteem has been demonstrated and replicated across three studies, conducted with distinct samples: two involving healthy participants and one involving a clinical sample of individuals with a chronic illness (Niveau et al., 2022, 2023).",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo of the Lexical Association Technique","The active control condition is based on the same procedural structure as the Lexical Association Technique (LAT), but without the core therapeutic component - the self-referential content. Participants in the control group are exposed to a series of positive statements, similar in form and valence to those used in the LAT, but referring to others (e.g., generic social roles or entities such as teachers, pharmacists, or animals) rather than the self.\n\nLike in the LAT condition, participants are asked to generate mental imagery based on each statement, visualizing a corresponding positive episodic event. This ensures that the control task involves the same cognitive mechanisms (episodic memory retrieval, positive visualization, and sustained attention), while excluding the specific associative link to the self that constitutes the active ingredient of the intervention.\n\nThis control condition was designed to match the LAT in terms of structure, cognitive demand, and duration, and has be",[15],[31],{"facility":32,"status":25,"city":33,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"CHU Grenoble Alpes","Grenoble","38043","France","FR",{"type":38,"coordinates":39},"Point",[40,41],5.71479,45.17869,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":25,"phoneExt":25,"email":25},"Mathieu VAILLANT, PH","PRINCIPAL_INVESTIGATOR",{"type":48,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[50,53],{"name":51,"class":52},"Laboratoire interuniversitaire de psychologie : personnalité, cognition et changement social - LIP-PC2S","UNKNOWN",{"name":54,"class":6},"Laboratoire de Psychologie et NeuroCognition","100597884","enhancing-self-esteem-in-patients-with-multiple-sclerosis-a-randomised-controlled-trial-of-the-lexical-association-technique-100597884",false,"NCT07064291","Enhancing Self-Esteem in Patients With Multiple Sclerosis: A Randomised Controlled Trial of the Lexical Association Technique","Améliorer l'Estime de Soi Des Patients Atteints de sclérose en Plaques : Test d'efficacité de la Technique d'Association Lexicale","SE-P-MS","INCLUSION CRITERIA\n\n* Native French speaker\n* Access to a computer and internet connection at home\n* Diagnosis of multiple sclerosis according to the revised criteria of Thompson et al. (2018), either relapsing-remitting or secondary progressive form, between 1 and 5 years since disease onset (RRMS or SPMS entry phase)\n* Currently receiving first- or second-line oral treatment (e.g., Teriflunomide, Dimethylfumarate, Fingolimod, Cladribine)\n* Adult participants (age ≥ 18)\n\nNON-INCLUSION CRITERIA\n\n* Participant currently excluded from another study\n* Individuals covered by Articles L1121-5 to L1121-8 of the French Public Health Code (CSP), i.e., legally protected persons: pregnant women, women in labor, breastfeeding mothers, individuals deprived of liberty by judicial or administrative decision, individuals under psychiatric care under Articles L.3212-1 and L.3213-1 not falling under Article L.1121-8, individuals admitted to healthcare or social institutions for reasons other than research, minors, individuals under legal protection or unable to provide informed consent\n* Staff members with a hierarchical link to the principal investigator\n\nSECONDARY EXCLUSION CRITERIA\n\n* Participants not presenting with low self-esteem, i.e., score \\>26 on the Self-Esteem Scale (EES; Vallières \\& Vallerand, 1990)\n* Major life event significantly affecting well-being in the two weeks prior to study inclusion (e.g., bereavement, separation, childbirth, etc.)\n* Initiation of psychological, psychiatric, or pharmacological treatment (anxiolytics, antidepressants) within one month prior to study start","ALL","18 Years",{"count":66,"type":67},160,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to learn whether the Lexical Association Technique (LAT) can improve well-being in people recently diagnosed with multiple sclerosis (MS), either relapsing-remitting (RRMS) or secondary progressive (SPMS).\n\nThe main questions it aims to answer are:\n\n* Does the LAT increase well-being more than a placebo technique ?\n* Does this technique help reduce psychological distress and improve quality of life ?\n\nParticipants will:\n\n* Be randomly assigned to either the LAT group or the active control group\n* Complete short visualization exercises at home using a personal computer\n* Fill out questionnaires about self-esteem, stress, anxiety, depression, quality of life, and adjustment to illness\n* Take part in the study over several weeks, with assessments before, after, and 14 days after the intervention\n\nResearchers will compare results between the two groups (LAT group vs. Control group) to test the immediate and lasting effects of the LAT.",[73,74],"Multiple Sclerosis","Quality of Life (QOL)",[73,76,77,78,79,80,81,82,83,84],"Psychological Well-Being","Lexical Association Technique","Randomized Controlled Trial","Quality of Life","Cognitive Intervention","Home-Based Therapy","Psychology","Mental Imagery","Self-esteem","NOT_YET_RECRUITING","2025-07-10",{"date":88,"type":89},"2025-07-14","ACTUAL",{"date":91,"type":67},"2025-09",{"date":93,"type":67},"2027-09",{"name":5,"class":6},1]