[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613110":3},{"organization":4,"outcomesModule":7,"designInfo":55,"detailedDescription":54,"studyPopulation":58,"armGroups":59,"interventions":54,"overallOfficials":63,"centralContacts":67,"locations":76,"responsibleParty":290,"collaborators":293,"id":297,"slug":298,"hasResults":299,"nctId":300,"briefTitle":301,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":299,"sex":304,"minAge":305,"maxAge":54,"enrollmentInfo":306,"targetDuration":54,"studyType":309,"phases":54,"briefSummary":310,"conditions":311,"keywords":318,"overallStatus":79,"whyStopped":54,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":335},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":54},[9],{"measure":10,"description":11,"timeFrame":12},"In-hospital mortality","The variable is coded as 1 = deceased and 0 = alive by the time of hospital discharge","From enrollment to hospital discharge or 90 days (whichever occurs first)",[14,18,22,26,30,33,36,40,44,48,51],{"measure":15,"description":16,"timeFrame":17},"ICU mortality","The variable is coded as 1 = deceased and 0 = alive by the time of ICU discharge","From enrollment to ICU discharge or 90 days (whichever occurs first)",{"measure":19,"description":20,"timeFrame":21},"90-day follow-up mortality","The variable is coded as 1 = deceased and 0 = alive by the time of 90-day follow-up","From enrollment to 90-days post-ICU admission follow-up",{"measure":23,"description":24,"timeFrame":25},"Length of stay in the ICU","Length of stay will be calculated as the total number of full days between admission and discharge from the ICU. A calendar day will be counted toward the total only if the duration of stay on that day is two hours or longer.","From ICU admission to death or ICU discharge (truncated at 90 days)",{"measure":27,"description":28,"timeFrame":29},"Length of stay in the hospital","Length of stay will be calculated as the total number of full days between admission and discharge from the hospital. A calendar day will be counted toward the total only if the duration of stay on that day is two hours or longer.","From hospital admission to death or hospital discharge (truncated at 90 days)",{"measure":31,"description":32,"timeFrame":12},"Renal function recovery at hospital discharge","Recovery will be defined as improvement in kidney function based on serum creatinine value at hospital discharge compared with baseline serum creatinine.\n\nBaseline serum creatinine will be defined as either of the following (in order of priority) 1) Average of 3 closest outpatient values 7-365 days before index hospitalization; 2) Lowest value in the inpatient setting 7-365 days before index hospitalization; 3) Lowest value in the first 30 days during index hospitalization (not during or within 48h after RRT discontinuation).\n\nPatients who have serum creatinine \\\u003C0.3 mg\u002FdL higher than baseline at hospital discharge will be considered to have recovered renal function.",{"measure":34,"description":35,"timeFrame":21},"Renal function recovery at follow-up","Recovery will be defined as improvement in kidney function based of serum creatinine value at follow-up compared with baseline serum creatinine.\n\nBaseline serum creatinine will be defined as either of the following (in order to priority) 1) Average of 3 closest outpatient values 7-365 days before index hospitalization; 2) Lowest value in the inpatient setting 7-365 days before index hospitalization; 3) Lowest value in the first 30 days during index hospitalization (not during or within 48h after RRT discontinuation).\n\nPatients who have serum creatinine \\\u003C0.3 mg\u002Fdl higher than baseline at follow-up will be considered to have recovered renal function.",{"measure":37,"description":38,"timeFrame":39},"RRT dependence at hospital discharge","Patients will be classified as RRT-dependent if they continue to require any form of RRT at discharge. Patients who no longer require RRT will be classified as RRT-independent.","From RRT initiation to hospital discharge or 90 days (whichever occurs first)",{"measure":41,"description":42,"timeFrame":43},"RRT dependence at follow-up","Patients will be classified as RRT-dependent if they continue to require any form of RRT at follow-up assessment. Patients who no longer require RRT will be considered RRT-independent.","From RRT initiation (day 0) to 90-days post-ICU admission follow-up",{"measure":45,"description":46,"timeFrame":47},"Anticoagulation-related complications associated with RRT","These include complications attributable to different types of anticoagulation (systemic unfractionated heparin, systemic low molecular weight heparin, regional citrate anticoagulation, other) used during RRT. Events include hemorrhage, heparin-induced thrombocytopenia (where relevant), citrate excess (where relevant), and citrate deficit (where relevant).","RRT initiation (day 0) to RRT day 6 or RRT termination (whichever occurs first)",{"measure":49,"description":50,"timeFrame":47},"Infectious complications associated with RRT","These include infections associated with RRT. Events include catheter-related bloodstream infections, catheter insertion-site infections, and secondary peritonitis.",{"measure":52,"description":53,"timeFrame":47},"RRT-related procedural complications","Procedural or mechanical complications occurring during RRT will be identified from medical records and bedside documentation. These include catheter malfunction (e.g., kinking, disconnection, malposition, migration, catheter tip adherence to vessel wall), circuit interruptions, circuit replacements, RRT downtime (where relevant).",null,{"allocation":54,"interventionModel":54,"interventionModelDescription":54,"primaryPurpose":54,"observationalModel":56,"timePerspective":57,"maskingInfo":54},"COHORT","RETROSPECTIVE","Critically ill patients with AKI requiring RRT in Latin American countries",[60],{"label":61,"type":54,"description":62,"interventionNames":54},"Acute kidney injury patients requiring renal replacement therapy","Critically ill adult patients with acute kidney injury undergoing any form of renal replacement therapy in Latin American hospitals",[64],{"name":65,"affiliation":5,"role":66},"Javier A Neyra, MD, MSCS","PRINCIPAL_INVESTIGATOR",[68,72],{"name":65,"role":69,"phone":70,"phoneExt":54,"email":71},"CONTACT","205-975-2021","jneyra@uabmc.edu",{"name":73,"role":69,"phone":74,"phoneExt":54,"email":75},"Patricia J Busta Flores","205-975-2251","pjbustaflores@uabmc.edu",[77,94,110,123,136,151,166,179,194,209,224,239,252,262,275],{"facility":78,"status":79,"city":80,"state":54,"zip":54,"country":81,"countryCode":82,"cosmosGeoPoint":83,"geoPoint":88,"contacts":89},"Hospital Obrero No 2","RECRUITING","Cochabamba","Bolivia","BO",{"type":84,"coordinates":85},"Point",[86,87],-66.15995,-17.38195,{"lat":87,"lon":86},[90],{"name":91,"role":69,"phone":92,"phoneExt":54,"email":93},"Rolando Claure-Del Granado","+591 (4) 4240022","rclaure@yahoo.com",{"facility":95,"status":96,"city":97,"state":54,"zip":54,"country":98,"countryCode":99,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Ana Nery Hospital","NOT_YET_RECRUITING","Bahia","Brazil","BR",{"type":84,"coordinates":101},[102,103],-40.24333,-3.55,{"lat":103,"lon":102},[106],{"name":107,"role":69,"phone":108,"phoneExt":54,"email":109},"Fernanda P Martin Tapioca","+55 71988502249","fernandapmartin@hotmail.com",{"facility":111,"status":96,"city":112,"state":54,"zip":54,"country":98,"countryCode":99,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Hospital Sao Lucas da PUCRS","Porto Alegre",{"type":84,"coordinates":114},[115,116],-51.23019,-30.03283,{"lat":116,"lon":115},[119],{"name":120,"role":69,"phone":121,"phoneExt":54,"email":122},"Daniele Cristovao Escouto","+55 5199624149","daniele.escouto@pucrs.br",{"facility":124,"status":96,"city":125,"state":54,"zip":54,"country":98,"countryCode":99,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Hospital das Clínicas da Universidade de São Paulo","São Paulo",{"type":84,"coordinates":127},[128,129],-46.63611,-23.5475,{"lat":129,"lon":128},[132],{"name":133,"role":69,"phone":134,"phoneExt":54,"email":135},"Camila Eleuterio Rodrigues","+ 55 11 94728 4006","camila.eleuterio@hc.fm.usp.br",{"facility":137,"status":96,"city":138,"state":54,"zip":54,"country":139,"countryCode":140,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Hospital Las Higueras","Talcahuano","Chile","CL",{"type":84,"coordinates":142},[143,144],-73.11684,-36.72494,{"lat":144,"lon":143},[147],{"name":148,"role":69,"phone":149,"phoneExt":54,"email":150},"Gonzalo Ramírez Guerrero","+56 981746173","ramirezguerrero.g@gmail.com",{"facility":152,"status":79,"city":153,"state":54,"zip":54,"country":154,"countryCode":155,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Fundación Cardioinfantil","Bogotá","Colombia","CO",{"type":84,"coordinates":157},[158,159],-74.08175,4.60971,{"lat":159,"lon":158},[162],{"name":163,"role":69,"phone":164,"phoneExt":54,"email":165},"Alejandra Molano- Triviño","+57 3453449865","alepatrimoltri@gmail.com",{"facility":167,"status":79,"city":168,"state":54,"zip":54,"country":154,"countryCode":155,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Hospital San Jose de Popayan","Popayán",{"type":84,"coordinates":170},[171,172],-76.61316,2.43823,{"lat":172,"lon":171},[175],{"name":176,"role":69,"phone":177,"phoneExt":54,"email":178},"David Ballesteros","+57 3105542506","david.ballesteros.c@gmail.com",{"facility":180,"status":79,"city":181,"state":54,"zip":54,"country":182,"countryCode":183,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Hospital General de la Plaza de la Salud","Santo Domingo","Dominican Republic","DO",{"type":84,"coordinates":185},[186,187],-69.89232,18.47186,{"lat":187,"lon":186},[190],{"name":191,"role":69,"phone":192,"phoneExt":54,"email":193},"Elin Guzman","829-571-1313","dr.elinguzman@gmail.com",{"facility":195,"status":96,"city":196,"state":54,"zip":54,"country":197,"countryCode":198,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"DIALNEF","Quito","Ecuador","EC",{"type":84,"coordinates":200},[201,202],-78.52495,-0.22985,{"lat":202,"lon":201},[205],{"name":206,"role":69,"phone":207,"phoneExt":54,"email":208},"Dario Jimenez","+59 3992773176","dxjimenezmd@gmail.com",{"facility":210,"status":96,"city":211,"state":54,"zip":54,"country":212,"countryCode":213,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Instituto Guatemalteco de Seguridad Social","Guatemala City","Guatemala","GT",{"type":84,"coordinates":215},[216,217],-90.51327,14.64072,{"lat":217,"lon":216},[220],{"name":221,"role":69,"phone":222,"phoneExt":54,"email":223},"Regina Sosa","+502 57311591","sosaregina@yahoo.com",{"facility":225,"status":79,"city":226,"state":54,"zip":54,"country":227,"countryCode":228,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"Hospital Civil de Guadalajara","Guadalajara","Mexico","MX",{"type":84,"coordinates":230},[231,232],-103.34749,20.67738,{"lat":232,"lon":231},[235],{"name":236,"role":69,"phone":237,"phoneExt":54,"email":238},"Jonathan Chavez","+52 3313299609","jonarchi_10@hotmail.com",{"facility":240,"status":96,"city":241,"state":54,"zip":54,"country":227,"countryCode":228,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Hospital General de México Dr Eduardo Liceaga","Mexico City",{"type":84,"coordinates":243},[244,245],-99.12766,19.42847,{"lat":245,"lon":244},[248],{"name":249,"role":69,"phone":250,"phoneExt":54,"email":251},"Pablo Galindo","+52 5551564682","galindozip@gmail.com",{"facility":253,"status":79,"city":241,"state":54,"zip":54,"country":227,"countryCode":228,"cosmosGeoPoint":254,"geoPoint":256,"contacts":257},"Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán",{"type":84,"coordinates":255},[244,245],{"lat":245,"lon":244},[258],{"name":259,"role":69,"phone":260,"phoneExt":54,"email":261},"Olynka Vega","+52 55 48039428.","olynkavega@gmail.com",{"facility":263,"status":79,"city":264,"state":54,"zip":54,"country":227,"countryCode":228,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"Hospital Universitario \"José Eleuterio González\"","Monterrey",{"type":84,"coordinates":266},[267,268],-100.31721,25.68435,{"lat":268,"lon":267},[271],{"name":272,"role":69,"phone":273,"phoneExt":54,"email":274},"Lilia Rizo-Topete","+52 8180297718","dra.liliarizo@gmail.com",{"facility":276,"status":79,"city":277,"state":54,"zip":54,"country":278,"countryCode":279,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Hospital Nacional Arzobispo Loayza","Lima","Peru","PE",{"type":84,"coordinates":281},[282,283],-77.02824,-12.04318,{"lat":283,"lon":282},[286],{"name":287,"role":69,"phone":288,"phoneExt":54,"email":289},"Yanissa Venegas Justiniano","+51 949709432","joanna.venegas.j@upch.pe",{"type":66,"investigatorFullName":291,"investigatorTitle":292,"investigatorAffiliation":5,"oldNameTitle":54,"oldOrganization":54},"Javier A. Neyra","Professor of Medicine",[294],{"name":295,"class":296},"Vantive Health LLC","INDUSTRY","100613110","epidemiology-and-processes-of-care-for-renal-replacement-therapy-in-acute-kidney-injury-in-latin-america-100613110",false,"NCT07262320","Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America","LATAM-AKID","Inclusion Criteria:\n\n* Adult patient (≥18) admitted to the ICU\n* First ICU admission during current hospitalization\n* Diagnosis of acute kidney injury stage 3 according to KDIGO guidelines\n* RRT initiated no earlier than 3 days before or no later than 7 days after ICU admission\n\nExclusion Criteria:\n\n* Transfer from outside hospital with ongoing RRT\n* RRT exposure of less than 2 days (if CRRT or PD was provided) or less than 2 HD\u002FSLED sessions\n* Kidney failure (ESRD) patients on maintenance dialysis\n* Kidney transplant recipients\n* Previous or new diagnosis of glomerulonephritis","ALL","18 Years",{"count":307,"type":308},1000,"ESTIMATED","OBSERVATIONAL","This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries. The main questions this study aims to answer are:\n\n* What is the epidemiology, outcomes, and processes of care for patients with AKI-RRT in Latin America?\n* How do outcomes differ across different countries in Latin America?\n* What factors (demographics, clinical, socioeconomic) influence outcomes in patients with AKI-RRT in Latin America?\n\nThe main aims of this study are to:\n\n* Establish a comprehensive database containing clinical, laboratory, treatment, process, and outcome data of patients with AKI-RRT in Latin America\n* Describe current epidemiology of AKI-RRT in Latin America\n* Compare processes of care and outcomes across different countries in Latin America\n* Provide data resources to facilitate and promote clinical research in AKI-RRT",[312,313,314,315,316,317],"Dialysis","Critically Ill Acute Kidney Injury","Renal Replacement Therapy for Acute Kidney Injury in ICU","Acute Kidney Injury","Renal Replacement Therapy","AKI",[317,319,320,321,322,323,324,325],"ICU","RRT","Latin America","acute kidney injury","renal replacement therapy","intensive care unit","dialysis","2026-03-11",{"date":328,"type":329},"2026-03-12","ACTUAL",{"date":331,"type":329},"2026-03-01",{"date":333,"type":308},"2027-06-30",{"name":5,"class":6},15]