[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651314":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":28,"responsibleParty":69,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":10,"enrollmentInfo":86,"targetDuration":10,"studyType":89,"phases":10,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":113,"whyStopped":10,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Istituti Clinici Scientifici Maugeri SpA","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Post COVID-19 patients",null,"Retrospective cohort of subjects that manifested COVID-19 and recovered without sequelae.\n\nInclusion criteria:\n\n* Age ≥ 18 years.\n* Previous SARS-CoV-2 infection documented by molecular or serological testing.\n* Absence of persistent symptoms 2 months after acute infection.\n* Willingness to provide written informed consent.",{"label":13,"type":10,"description":14,"interventionNames":10},"Long COVID-19 patients","Retrospective and prospective cohorts of patients that manifested COVID-19 and developed sequelae. The retrospective cohort includes subjects with long COVID-19 with or without cardiac symptoms. The prospective cohort includes patients with long COVID-19 and gastrointestinal symptoms.\n\nInclusion criteria:\n\n* Age ≥ 18 years.\n* Previous SARS-CoV-2 infection documented by molecular or serological testing.\n* Persistent symptoms at least 2 months after acute infection, according to the WHO definition of long COVID \\[https:\u002F\u002Fwww.who.int\u002Feurope\u002Fnews-room\u002Ffact-sheets\u002Fitem\u002Fpost-covid-19-condition\\].\n* Willingness to provide written informed consent.",{"label":16,"type":10,"description":17,"interventionNames":10},"Control Group","Retrospective cohort of subjects who never had SARS-CoV-2 infection.\n\nInclusion criteria:\n\n* Age ≥ 18 years.\n* No previous SARS-CoV-2 infection (documented by serology).\n* Blood sample collected according to the COVID-BioVac protocol (NCT05276388) before the first administration of the SARS-CoV-2 vaccine.\n* Willingness to provide written informed consent.",[19,24],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Carlo Gaetano, Professor","CONTACT","+390382592262","carlo.gaetano@icsmaugeri.it",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Michela Gottardi Zamperla, PhD","+390382593563","michela.gottardizamperla@icsmaugeri.it",[29,47,56],{"facility":30,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Istituto Auxologico Italiano","Cusano Milanino","Milano","20095","Italy","IT",{"type":37,"coordinates":38},"Point",[39,40],9.18373,45.55187,{"lat":40,"lon":39},[43],{"name":44,"role":21,"phone":45,"phoneExt":10,"email":46},"Davide Gentilini, Professor","+3902619113038","d.gentilini@auxologico.it",{"facility":48,"status":10,"city":49,"state":10,"zip":50,"country":34,"countryCode":35,"cosmosGeoPoint":51,"geoPoint":55,"contacts":10},"Ospedale San Raffaele S.r.l.","Milan","20132",{"type":37,"coordinates":52},[53,54],12.59836,42.78235,{"lat":54,"lon":53},{"facility":57,"status":10,"city":58,"state":10,"zip":59,"country":34,"countryCode":35,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Istituti Clinici Scientifici Maugeri","Pavia","27100",{"type":37,"coordinates":61},[62,63],9.15917,45.19205,{"lat":63,"lon":62},[66,68],{"name":20,"role":21,"phone":67,"phoneExt":10,"email":23},"+3903822262",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},{"type":70,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[72,74],{"name":73,"class":6},"IRCCS Ospedale San Raffaele",{"name":30,"class":6},"100651314","epigenetic-changes-in-long-covid-patients-100651314",false,"NCT07757620","Epigenetic Changes in Long COVID Patients","Epigenetic Changes in Long COVID Patients: Unraveling the Gut-Immune Axis and Therapeutic Targets","ECLIPSE","Inclusion Criteria (Post COVID-19 patients):\n\n* Age ≥ 18 years.\n* Previous SARS-CoV-2 infection documented by molecular or serological testing.\n* Absence of persistent symptoms 2 months after acute infection.\n* Willingness to provide written informed consent.\n\nInclusion Criteria (Long COVID-19 patients):\n\n* Age ≥ 18 years.\n* Previous SARS-CoV-2 infection documented by molecular or serological testing.\n* Persistent symptoms at least 2 months after acute infection, according to the WHO definition of long COVID \\[https:\u002F\u002Fwww.who.int\u002Feurope\u002Fnews-room\u002Ffact-sheets\u002Fitem\u002Fpost-covid-19-condition\\].\n* Willingness to provide written informed consent.\n\nInclusion Criteria (Control Group):\n\n* Age ≥ 18 years.\n* No previous SARS-CoV-2 infection (documented by serology).\n* Blood sample collected according to the COVID-BioVac protocol (NCT05276388) before the first administration of the SARS-CoV-2 vaccine.\n* Willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Inability to provide informed consent.\n* Presence of severe systemic autoimmune diseases or congenital\u002Facquired immunodeficiencies that may confound the interpretation of immunological data.\n* Current systemic immunosuppressive therapy or treatment within the last 6 months prior to enrollment.\n* Active malignancies or those treated within the last 12 months (except basal or squamous cell carcinomas in situ).\n* Pregnancy or breastfeeding at the time of enrollment.\n* Any other clinical condition that, in the investigator's opinion, could compromise the reliability of the data collected.",true,"ALL","18 Years",{"count":87,"type":88},1000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine approaches in adults with long COVID, adults who have fully recovered from COVID-19, and healthy control participants.\n\nThe main questions it aims to answer are:\n\n* What molecular, immunological, epigenetic, and microbiome profiles distinguish individuals with long COVID from recovered COVID-19 participants and healthy controls?\n* How are viral persistence, immune dysregulation, and alterations in the gut-immune axis associated with the development and clinical manifestations of long COVID?\n* Which molecular biomarkers may improve disease diagnosis, patient stratification, and the identification of potential therapeutic targets?\n\nParticipants will:\n\n* Undergo clinical evaluation and provide information about their medical history and symptoms.\n* Provide biological samples, including blood and, when clinically indicated, intestinal biopsy tissue collected during routine colonoscopy procedures.\n* Undergo comprehensive molecular analyses, including immunological, epigenetic, transcriptomic, proteomic, and microbiome profiling.\n* Have their clinical and molecular data integrated using advanced computational approaches to identify biological signatures associated with long COVID.\n\nThe results of this study may improve the understanding of the biological mechanisms underlying long COVID and support the development of novel biomarkers and future precision medicine approaches for diagnosis, prognosis, patient stratification, and therapeutic target identification.",[92,93],"Long COVID-19 Syndrome","Long COVID Symptoms",[95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112],"Long COVID-19","COVID-19","gut","Chronic inflammation","epigenetics","methylation","omics","artificial intelligence","ai","machine learning","Multi-omics approaches","biomarker","Immune aging","genomics","transcriptomics","spatial omics","epigenomics","cytokines","NOT_YET_RECRUITING","2026-08-05",{"date":116,"type":117},"2026-08-11","ACTUAL",{"date":119,"type":88},"2026-09",{"date":121,"type":88},"2027-12",{"name":5,"class":6},3]