[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645686":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":26,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":67,"whyStopped":26,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":75,"locationsCount":26},{"fullName":5,"class":6},"Beijing Friendship Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Esketamine arm","EXPERIMENTAL","Participants receive intravenous esketamine in combination with propofol for procedural sedation during ERCP. Esketamine is administered as an adjunct analgesic during induction of sedation, while propofol is continuously infused and titrated according to clinical sedation requirements.",[13],"Drug: Esketamine",{"label":15,"type":16,"description":17,"interventionNames":18},"Sufentanil arm","ACTIVE_COMPARATOR","Participants receive intravenous sufentanil in combination with propofol for procedural sedation during ERCP. Sufentanil is administered as an adjunct analgesic during induction of sedation, while propofol is continuously infused and titrated according to clinical sedation requirements.",[19],"Drug: Sufentanil",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Esketamine","Intravenous esketamine is administered as an adjunct analgesic during induction of sedation for ERCP. It is used in combination with continuously infused propofol, with dosing titrated to achieve adequate procedural sedation. This regimen differs from the comparator arm in that esketamine is used as the primary analgesic agent instead of an opioid.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sufentanil","Intravenous sufentanil is administered as an adjunct analgesic during induction of sedation for ERCP. It is used in combination with continuously infused propofol, with dosing titrated to achieve adequate procedural sedation. This regimen differs from the comparator arm in that sufentanil is used as the opioid-based analgesic instead of esketamine.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Tingting Fan, PhD","CONTACT","86+13439211460","fantt_aki@126.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Ren Da","Attending Anesthesiologist","100645686","esketamine-versus-sufentanil-for-sedation-in-patients-undergoing-ercp-100645686",false,"NCT07702240","Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP","Effects of Esketamine-Propofol Versus Sufentanil-Propofol Sedation on Hypoxemia and Hypotension During Endoscopic Retrograde Cholangiopancreatography (ERCP)","ES-ERCP","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Patients scheduled to undergo endoscopic retrograde cholangiopancreatography (ERCP)\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body mass index (BMI) between 18.5 and 30 kg\u002Fm²\n* Patients requiring sedation for ERCP\n* Ability to provide written informed consent voluntarily\n\nExclusion Criteria:\n\n* Allergy or contraindication to propofol, esketamine, sufentanil, or related medications\n* Severe hypertension (systolic blood pressure ≥180 mmHg and\u002For diastolic blood pressure ≥110 mmHg)\n* Severe dysfunction of the heart, lungs, liver, or kidneys\n* History of central nervous system disorders or psychiatric disorders\n* Anticipated difficult airway\n* History of psychiatric disorders or contraindications to ketamine use\n* Inability to communicate or provide informed consent\n* Requirement for general anesthesia with endotracheal intubation or intraoperative conversion to general anesthesia with intubation","ALL","18 Years","90 Years",{"count":53,"type":54},530,"ESTIMATED","INTERVENTIONAL",[57],"NA","This study compares two anesthesia medications, esketamine and sufentanil, used together with propofol during ERCP procedures. The goal is to find out which combination provides better safety and comfort for people undergoing ERCP.\n\nParticipants will be randomly assigned to receive either esketamine or sufentanil during sedation. Researchers will monitor blood oxygen levels, blood pressure, and recovery time during and after the procedure to evaluate safety and effectiveness.",[60,61],"Biliary Tract Diseases","Procedural Sedation and Analgesia",[63,61,23,28,64,65,66],"Endoscopic Retrograde Cholangiopancreatography (ERCP)","Propofol","Randomized Controlled Trial","Frail Patients","NOT_YET_RECRUITING","2026-07-10",{"date":70,"type":71},"2026-07-14","ACTUAL",{"date":68,"type":54},{"date":74,"type":54},"2028-03-10",{"name":39,"class":6}]