[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646681":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":56,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":85,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Centre of Postgraduate Medical Education","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Erector spine plane block (ESPB)","EXPERIMENTAL","Bilateral ESPB performed before induction of anesthesia",[13],"Procedure: Ultrasound - guided Erector Spine Plane Block (ESPB)",{"label":15,"type":10,"description":16,"interventionNames":17},"Lidocaine infusion","Intravenous lidocaine bolus infusion started before induction of anesthesia and continued until the end of surgery",[18],"Procedure: Intraoperative intravenous lidocaine infusion",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Ultrasound - guided Erector Spine Plane Block (ESPB)","Bilateral ultrasound - guided ESPB will be performed before induction of anesthesia using 20 mL of 0.25% bupivacaine per side (total volume 40 mL).",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Intraoperative intravenous lidocaine infusion","Patients will receive an intravenous lidocaine bolus of 1.5 mg\u002Fkg over 10 minutes before induction of anesthesia, followed by a continuous infusion of 1.5 mg\u002Fkg\u002Fh (0.15 mL\u002Fkg\u002Fh) until placement of the final skin suture.",[15],[31],{"name":32,"affiliation":33,"role":34},"Małgorzata Malec-Milewska, MD, Prof.","Department of Anesthesia and Intensive Care, Orlowski Hospital, Warsaw","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Bartosz Horosz, MD,PhD","CONTACT","0048225841122","bartosz.horosz@gmail.com",{"name":42,"role":38,"phone":25,"phoneExt":25,"email":25},"Katarzyna Białowolska-Horosz, MD,PhD",[44],{"facility":45,"status":25,"city":46,"state":25,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":25},"Centre of Postgraduate Medical Education,Department of Anesthesia and Intensive Care","Warsaw","01-813","Poland","PL",{"type":51,"coordinates":52},"Point",[53,54],21.01178,52.22977,{"lat":54,"lon":53},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Bartosz Horosz, MD","MD,PhD","100646681","espb-versus-intravenous-lidocaine-for-pain-after-mastopexy-100646681",false,"NCT07687069","ESPB Versus Intravenous Lidocaine for Pain After Mastopexy","Erector Spinae Plane Block (ESPB) Versus Intravenous Lidocaine Infusion for Postoperative Pain and Quality of Recovery in Patients Undergoing Breast Reduction Surgery: A Single Center, Prospective, Randomized Study.","Inclusion Criteria:\n\n* ASA physical status I-III\n* Scheduled for elective breast reduction surgery for non-oncological indications\n\nExclusion Criteria:\n\n* Refusal or inability to provide written informed consent\n* History of chronic somatic or neuropathic pain\n* Current psychiatric disorders or ongoing treatment with antidepressant medications\n* Poorly controlled cardiovascular disease\n* Known allergy or intolerance to amide local anesthetics, including lidocaine and bupivacaine\n* Current alcohol abuse or substance use disorder","FEMALE","18 Years","75 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"NA","Elective breast reduction surgery is associated with moderate-to-severe postoperative pain and a risk of developing chronic postsurgical pain. Enhanced Recovery After Surgery (ERAS) protocols and the Procedure-Specific Postoperative Pain Management (PROSPECT) guidelines emphasize the importance of multimodal analgesia to reduce pain, minimize opioid consumption, and accelerate functional recovery following surgical procedures, including breast surgery.\n\nThe erector spinae plane block (ESPB) has demonstrated effectiveness in breast reduction surgery by reducing postoperative pain intensity, perioperative opioid and non-opioid analgesic consumption, and improving patient satisfaction and recovery time. Furthermore, the use of ESPB has been associated with a reduced incidence of postoperative nausea and vomiting. ESPB is performed with the patient in the sitting position and involves ultrasound-guided identification of the vertebral transverse processes on the side of the block, typically in the interscapular region, followed by the injection of approximately 20 mL of local anesthetic adjacent to the transverse process. When required, the procedure is performed bilaterally at the same vertebral level. ESPB is considered one of the simplest regional anesthesia techniques to perform.\n\nIntravenous lidocaine infusion has been shown to significantly reduce opioid requirements and postoperative pain intensity across a wide range of surgical procedures, particularly in abdominal and breast surgery. Moreover, intraoperative lidocaine infusion has been associated with a reduced risk of chronic postsurgical pain following breast surgery.\n\nThis study was designed to investigate whether intraoperative intravenous lidocaine infusion is non-inferior to ESPB in reducing postoperative pain and improving the quality of recovery following non-oncological breast reduction surgery. Intravenous lidocaine infusion may provide analgesic efficacy and recovery outcomes comparable to those achieved with ESPB, thereby representing a less invasive alternative within a multimodal analgesic strategy.",[78],"Breast Hypertrophy",[80,81,82,83,84],"breast reduction","postoperative pain","erector spine plane block","lidocaine","pain modulation","NOT_YET_RECRUITING","2026-07-03",{"date":88,"type":89},"2026-07-07","ACTUAL",{"date":91,"type":72},"2026-07",{"date":93,"type":72},"2028-08",{"name":5,"class":6},1]