[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654135":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":22,"interventions":35,"overallOfficials":13,"centralContacts":45,"locations":51,"responsibleParty":66,"collaborators":13,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":13,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":13,"enrollmentInfo":79,"targetDuration":13,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":13,"overallStatus":88,"whyStopped":13,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Sohag University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Change in striae rubra severity assessed by Physician's Global Assessment-based quartile grading scale","Striae rubra severity will be assessed using a Physician's Global Assessment-based quartile grading scale, expressed as percentage response. The scale ranges from 0% to 100%, with higher values indicating a better treatment response. Responses are categorized as poor response (\\\u003C25%), mild response (25-50%), moderate response (50-75%), and excellent response (\\>75%).","At baseline and at weeks 3, 6, 9, and 12",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":20},"SINGLE",[21],"PARTICIPANT",[23,29],{"label":24,"type":25,"description":26,"interventionNames":27},"Microneedling plus topical tranexamic acid","ACTIVE_COMPARATOR","Participants will receive microneedling followed by topical application of tranexamic acid to the affected striae rubra areas every 3 weeks for a maximum of five sessions.",[28],"Drug: Topical tranexamic acid",{"label":30,"type":31,"description":32,"interventionNames":33},"Microneedling plus topical normal saline","PLACEBO_COMPARATOR","Participants will receive microneedling followed by topical application of normal saline to the affected striae rubra areas every 3 weeks for a maximum of five sessions",[34],"Other: normal saline (0.9% NaCl)",[36,41],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":13},"DRUG","Topical tranexamic acid","Topical tranexamic acid solution100 mg\u002FmL (ampoule 500 mg\u002F5 mL, Amoun Pharmaceutical Company) Microneedling will then be performed uniformly using multiple passes (horizontal, vertical, and oblique) on both sides of the affected area till erythema with pinpoint bleeding is achieved.",[24],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":13},"normal saline (0.9% NaCl)","normal saline (0.9% NaCl) will be applied to the control side. Microneedling will then be performed uniformly using multiple passes (horizontal, vertical, and oblique) on both sides of the affected area till erythema with pinpoint bleeding is achieved",[30],[46],{"name":47,"role":48,"phone":49,"phoneExt":13,"email":50},"hager adel","CONTACT","01010207262","hageradel0100@gmail.com",[52],{"facility":53,"status":13,"city":54,"state":13,"zip":13,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Faculity of Medicine ,Sohag University","Sohag","Egypt","EG",{"type":58,"coordinates":59},"Point",[60,61],31.69478,26.55695,{"lat":61,"lon":60},[64],{"name":47,"role":48,"phone":49,"phoneExt":13,"email":65},"hager.adel@med.sohag.edu.eg",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Hager Adel Mohamed","Dermatology Resident, Sohag General Hospital","100654135","evaluating-the-effectiveness-and-safety-of-microneedling-with-topical-tranexamic-acid-in-treatment-of-striae-rubra-100654135",false,"NCT07795515","Evaluating the Effectiveness and Safety of Microneedling With Topical Tranexamic Acid in Treatment of Striae Rubra","Evaluating the Effectiveness and Safety of Microneedling With Topical Tranexamic Acid in Treatment of Striae Rubra; Asplit Body Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients of both gender aged ≥18 years, clinically and dermoscopically diagnosed with bilateral symmetrical striae rubra (present on corresponding anatomical sites on both sides of the body with approximately symmetrical distribution and similar clinical appearance (color, width, and stage of evolution)). and willing to participate and sign informed consent\n\nExclusion Criteria:\n\n* • Striae alba.\n\n  * Pregnancy or lactation.\n  * History of keloids or hypertrophic scars.\n  * Active skin infection in treatment area.\n  * Patients using other modalities of treatment for over the last 3 months.\n  * Patients with bleeding disorders or on anticoagulant therapy.\n  * Patients using drugs that exacerbate the striae as systemic corticosteroids in the preceding 3 months or topical corticosteroid in the preceding one month.","ALL","18 Years",{"count":80,"type":81},50,"ESTIMATED","INTERVENTIONAL",[84],"NA","This study aims to evaluate the efficacy and safety of microneedling with topical tranexamic acid versus microneedling with placebo (normal saline) in the treatment of striae rubra.\n\nOne side of the affected area (the intervention side) will receive topical tranexamic acid at a concentration of 100 mg\u002FmL (Kapron® ampoules, 500 mg\u002F5 mL; Amoun Pharmaceutical Co.), followed by a microneedling session.\n\nThe contralateral side (the control side) will receive a placebo-specifically, 0.9% normal saline-followed by a microneedling session performed in the same manner as on the intervention side.\n\nTreatment sessions will be conducted every three weeks-up to a maximum of five sessions, depending on the patient's clinical improvement-at weeks 0, 3, 6, 9, and 12, for a total treatment duration of 12 weeks",[87],"Striae Rubra","NOT_YET_RECRUITING","2026-09-05",{"date":91,"type":92},"2026-09-10","ACTUAL",{"date":94,"type":81},"2026-10-01",{"date":96,"type":81},"2027-06-01",{"name":5,"class":6},1]