[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600277":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":29,"responsibleParty":47,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":18,"maxAge":18,"enrollmentInfo":58,"targetDuration":18,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":72,"whyStopped":18,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Universidad Villanueva","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Strength training group","EXPERIMENTAL","An intervention based on the application of a strength training protocol for multi-joint and single-joint muscles will be implemented, performed with a slow-moderate execution speed. This intervention will be carried out over 12 weeks, with a total of 24 sessions (2 sessions per week), each lasting 45 minutes. In all of these sessions, free weights will be used, performing three sets at 60-80% of 1RM for 8-12 repetitions.\n\nThe exercise protocol will include:\n\n* Squats\n* Deadlifts\n* Rows\n* Bicep curls\n* Bench press\n* Shoulder press\n\nEach set will be performed to muscular failure, progressing in the number of repetitions (from 8 to 12). Once 12 repetitions are reached, the load volume will be increased by adding 5% to the weight.",[13],"Other: strength training",[15],{"type":6,"name":16,"description":11,"armGroupLabels":17,"otherNames":18},"strength training",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Noelia Díaz López, Doctor","STUDY_DIRECTOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Selena Marcos Antón, Doctor","CONTACT","+34 692824096","selena.marcos@villanueva.edu",[30],{"facility":5,"status":18,"city":31,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Madrid","28034","Spain","ES",{"type":36,"coordinates":37},"Point",[38,39],-3.70256,40.4165,{"lat":39,"lon":38},[42,43,45],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},{"name":25,"role":44,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"name":21,"role":46,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"type":44,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Noelia Diaz Lopez","Doctor","100600277","evaluation-of-functional-and-biochemical-effectiveness-of-a-strength-training-protocol-in-parkinsons-disease-100600277",false,"NCT07095400","Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease","POWER-PD","Inclusion Criteria:\n\n* Patients diagnosed with PD who meet the modified diagnostic criteria of the UK Brain Bank.\n* Patients in stage II or III of the Hoehn and Yahr Scale.\n* A score greater than 60% on the Schwab and England Functional Scale.\n* Patients whose motor response to pharmacological treatment is stable or slightly fluctuating and who are not receiving any specific strength training rehabilitation treatment at the time of the study.\n\nExclusion Criteria:\n\n* Diagnosis of a condition other than PD.\n* Significant comorbidities and\u002For severe systemic diseases that would prevent participation in exercise (e.g., recent surgery, cardiac instability, anemia, hepatosis, pulmonary disorders, chronic renal failure, or severe mental disorders).\n* Inability to actively understand instructions and cooperate in the tasks given, based on a score \\\u003C24 on the Mini-Mental State Examination (MMSE).\n* Refusal to participate in the study.\n* Stages I, IV, or V of the Hoehn and Yahr Scale.","ALL",{"count":59,"type":60},22,"ESTIMATED","INTERVENTIONAL",[63],"NA","Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms including anxiety, depression, and cognitive decline. Strength training has emerged as a promising intervention to improve motor function and influence biochemical markers associated with oxidative stress and neurodegeneration. This study aims to evaluate the effectiveness of a structured strength training protocol over 12 weeks in improving both functional and biochemical outcomes in patients with PD.",[66],"Parkinson Disease",[16,68,69,70,71],"physical exercise","oxidative stress","neurofilament light chain","parkinson's disease","NOT_YET_RECRUITING","2025-07-23",{"date":75,"type":76},"2025-07-31","ACTUAL",{"date":78,"type":60},"2025-09-07",{"date":80,"type":60},"2027-06",{"name":5,"class":6},1]