[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649191":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":57,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":87,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University Hospital Tuebingen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LtAPD","EXPERIMENTAL","Treatment with low-thermal argon plasma devitalization",[13],"Device: Treatment with low-thermal argon plasma devitalization",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham","SHAM_COMPARATOR","Sham treatment",[19],"Device: Sham treatment",[21,26],{"type":22,"name":11,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Single session of LtAPD treatment applied to the CIN2 lesion under colposcopic guidance; outpatient, no anesthesia required.",[9],null,{"type":22,"name":17,"description":27,"armGroupLabels":28,"otherNames":25},"Single session of sham treatment (no argon gas delivery and plasma ignition; acoustic signal to maintain blinding) followed by active surveillance according to current clinical guidelines.",[15],[30],{"name":31,"affiliation":32,"role":33},"Felix Neis, PD Dr.","University Hospital Tuebingen, Department of Women's Health, Tübingen","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Martin Weiss, Prof. Dr.","CONTACT","+49 7071 29 82211","martin.weiss@med.uni-tuebingen.de",[41],{"facility":42,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University Hospital Tuebingen, Department of Women's Health","Tübingen","Baden-Wurttemberg","72076","Germany","DE",{"type":49,"coordinates":50},"Point",[51,52],9.05222,48.52266,{"lat":52,"lon":51},[55],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":56},"martin.-weiss@med.uni-tuebingen.de",{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100649191","evaluation-of-low-thermal-argon-plasma-devitalization-for-the-treatment-of-cin-2-versus-standard-of-active-surveillance-100649191",false,"NCT07730645","Evaluation of Low-thermal Argon Plasma Devitalization for the Treatment of CIN 2 Versus Standard of Active Surveillance","Evaluation of Low-thermal Argon Plasma Devitalization (LtAPD) for the Treatment of Cervical Intraepithelial Neoplasia (CIN) Grade 2 Versus Standard of Active Surveillance","CINPLASTA","Inclusion Criteria:\n\n* Female sex\n* Age 18 - 40 years at the time of signing the informed consent\n* Histologically confirmed CIN 2\n* Full visibility of the entire transformation zone (Type 1 or Type 2) and entire lesion in colposcopy\n* Ability to understand the nature of the clinical investigation and voluntarily signs the informed consent document prior to any study-related procedures\n\nExclusion Criteria:\n\n* Histologically confirmed CIN other than CIN 2, or indication of (micro-) invasive cervical disease\n* CIN lesions extending to the vaginal vault or suspicion of endocervical disease\n* Current pregnancy or planned pregnancy within the next 6 months\n* Presence of severe local inflammation or active infection\n* Presence of a severe cardiovascular, neurological, psychiatric, endocrine, or hematological disease, immunocompromised condition or malignant tumor of any origin, as judged by the investigator\n* Participation in an interfering clinical study, as judged by the investigator","FEMALE","18 Years","40 Years",{"count":71,"type":72},264,"ESTIMATED","INTERVENTIONAL",[75],"NA","The study aims to show that treatment with LtAPD works better than a sham treatment or simply monitoring the condition closely without active treatment (\"active surveillance\"), in achieving complete healing of a tissue abnormality on the cervix called CIN 2, after 6 months. This will be confirmed by examining tissue samples under a microscope (histopathological examination).",[78,79,80],"Cervical Intraepithelial Neoplasia Grade 2 (CIN2)","Cervical Intraepithelial Neoplasia Grade 2","CIN2",[80,79,82,9,83,84,85,86],"Low-thermal argon plasma devitalization","Plasma application","Plasma treatment","Physical plasma","Physical plasma treatment","NOT_YET_RECRUITING","2026-07-31",{"date":90,"type":91},"2026-08-03","ACTUAL",{"date":93,"type":72},"2026-08-17",{"date":95,"type":72},"2029-09-30",{"name":5,"class":6},1]