[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650709":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":30,"locations":29,"responsibleParty":36,"collaborators":41,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":29,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":29,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":72,"whyStopped":29,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":29},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Subgingival administration of 0.05% zoledronate gel","ACTIVE_COMPARATOR","MINST will be performed followed by Subgingival administration of 0.05% zoledronate gel",[13],"Procedure: All participants will receive MINST",{"label":15,"type":10,"description":16,"interventionNames":17},"Subgingival administration of 1% metformin gel","MINST will be performed followed by Subgingival administration of 1% metformin gel",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Subgingival administration of placebo gel","PLACEBO_COMPARATOR","MINST will be performed followed by Subgingival administration of placebo gel",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","All participants will receive MINST","using ultrasonic scalers and hand curettes over two sessions within 1 week.",[9,15,19],null,[31],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"Parryhan M Abdelsamie","CONTACT","01003082353","Parryhan.abdelsamie@dentistry.cu.edu.eg",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":40,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Parryhan Mohamed Abdelsamie","Lecturer of periodontology","MTI University",[42],{"name":43,"class":44},"Egyptian Russian University","NETWORK","100650709","evaluation-of-subgingival-1-metformin-gel-versus-005-zoledronate-gel-as-an-adjunct-to-minst-of-intrabony-defects-in-controlled-type-2-dm-100650709",false,"NCT07753317","Clinical and Radiographic Evaluation of Subgingival 1% Metformin Gel Versus 0.05% Zoledronate Gel as an Adjunct to MINST of Intrabony Defects in Controlled Type 2 DM","Clinical and Radiographic Evaluation of Subgingival 1% Metformin Gel Versus 0.05% Zoledronate Gel as an Adjunct to Minimally Invasive Nonsurgical Treatment of Intrabony Defects in Controlled Type 2 Diabetic Patients With Periodontitis. A Placebo Randomized Controlled Trial.","Inclusion Criteria:\n\n* Diagnosed with type 2 diabetes mellitus, with HbA1c levels \\\u003C7.0% (controlled).\n* Diagnosis of chronic periodontitis (Stage III\u002FIV, Grade B\u002FC) with at least one intrabony defect of ≥3 mm depth, PPD ≥5 mm, and CAL ≥4 mm measured with a calibrated UNC-15 probe.\n* Angular bone loss of ≥3 mm measured on digital intraoral periapical radiographs and having three walled intrabony defects without involving furcation confirmed on cone beam computed tomography (CBCT).\n\nExclusion Criteria:\n\n1. Smokers.\n2. Pregnant or lactating women.\n3. Patients on systemic bisphosphonate therapy or other medications known to affect bone metabolism.\n4. Uncontrolled diabetes (HbA1c \\>8%) or other systemic diseases that could affect periodontal status.\n5. History of radiation therapy to the head and neck",true,"ALL","30 Years","60 Years",{"count":57,"type":58},30,"ESTIMATED","INTERVENTIONAL",[61],"NA","The present randomized placebo-controlled trial aims to evaluate and compare the clinical and radiographic efficacy of subgingivally delivered 0.05% zoledronate gel and 1% metformin gel as adjuncts to minimally invasive nonsurgical treatment of intrabony defects in patients with controlled type 2 diabetes mellitus and periodontitis.",[64],"Controlled Type 2 Diabetic Patients With Periodontitis",[66,67,68,69,70,71],"Metformin gel","Zoledronate gel","nonsurgical treatment","Intrabony Defects","type 2 diabetes","Periodontitis","NOT_YET_RECRUITING","2026-08-09",{"date":75,"type":76},"2026-08-11","ACTUAL",{"date":78,"type":58},"2026-08-07",{"date":80,"type":58},"2027-03-01",{"name":5,"class":6}]