[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648804":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Bicetre Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"patients with shock",null,"Patients with shock defined by one sign of hypoperfusion:\n\n* systolic arterial pressure \\\u003C90mmHg\n* mean arterial pressure \\\u003C65mmHg\n* prolonged capillary refill time \\>3 sec\n* mottling score \\> 2\n* urine output \\\u003C 0.1 mL\u002Fkg\u002Fh",[13,14],"Drug: Fluid bolus","Drug: Norepinephrine",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DRUG","Fluid bolus","Giving a fluid bolus of 500mL of normal saline (NaCl 0.9%)",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Norepinephrine","brief, transient increase in norepinephrine to achieve a 15mmHg increase in mean arterial pressure and evaluates if tissue perfusion improves",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Christopher Lai, MD, PhD","CONTACT","12633816521","christopher.lai@aphp.fr",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Bicêtre Hospital","RECRUITING","Le Kremlin-Bicêtre","France","FR",{"type":39,"coordinates":40},"Point",[41,42],2.36073,48.81471,{"lat":42,"lon":41},[45],{"name":46,"role":28,"phone":47,"phoneExt":10,"email":30},"Christopher Lai","2633816521",{"type":49,"investigatorFullName":46,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Doctor","100648804","evaluation-of-the-argos-system-to-estimate-cardiac-output-100648804",false,"NCT07724262","Evaluation of the Argos System to Estimate Cardiac Output","Evaluation of the Argos System to Estimate Cardiac Output in Critically Ill Patients","Inclusion Criteria:\n\n* Age ≥18 years old\n* Hospitalisation in intensive care\n* Haemodynamic monitoring with transpulmonary thermodilution already in place\n* Hemodynamic intervention deemed necessary by the clinician in charge of the patient\n\n  * Administration of a fluid bolus\n  * Change in norepinephrine dosage or performance of a vasopressor test\n\nExclusion Criteria:\n\n* Pregnancy\n* Other therapeutic modification during volume expansion or the vasopressor test\n* Refusal to participate by relatives of the patient or the patient himself or herself\n* Non availability of investigators","ALL","18 Years",{"count":61,"type":62},120,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate the reliability of the Argos system to track changes in cardiac output in critically ill patients. The main question it aims to answer is:\n\nDoes cardiac output changes induced by fluid administration or changes in norepinephrine dosage can be tracked by the Argos system, compared to transpulmonary thermodilution device.",[66],"Shock",[68,69,70,71],"hemodynamic monitoring","vasopressor","fluids","cardiac output","2026-07-20",{"date":74,"type":75},"2026-07-24","ACTUAL",{"date":77,"type":75},"2026-02-01",{"date":79,"type":62},"2027-01-31",{"name":5,"class":6},1]