[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650177":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":39,"locations":25,"responsibleParty":44,"collaborators":25,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":25,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":25,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":79,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":25},{"fullName":5,"class":6},"Ariana Medical Complex","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Structured Culturally Adapted Home-Based Exercise Program","EXPERIMENTAL","Participants assigned to this arm will receive usual psychiatric care plus a structured, culturally adapted home-based exercise program. The intervention includes an illustrated exercise booklet containing breathing, stretching, walking, and light-to-moderate aerobic exercises that can be performed safely at home without specialised equipment. Participants will receive initial visual instruction on performing the exercises and will be encouraged to choose exercises according to their preferences, physical abilities, and available time during the 8-week study period. Participants will record each exercise session in a logbook to monitor exercise adherence.",[13],"Behavioral: Structured Culturally Adapted Home-Based Exercise Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Routine Exercise Advice","ACTIVE_COMPARATOR","Participants assigned to this arm will receive usual psychiatric care and routine advice on the benefits of physical activity, including general recommendations such as walking and household physical activities. They will not receive the structured home-based exercise program, illustrated exercise booklet, or exercise instruction provided to the experimental group. Participants will receive an exercise logbook to record any physical activity or exercise performed during the 8-week study period, allowing comparison of exercise adherence between the study groups.",[19],"Behavioral: Routine Exercise Advice",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Participants will receive a structured, culturally adapted home-based exercise program in addition to usual psychiatric care. The intervention includes an illustrated exercise booklet containing breathing, stretching, indoor walking, brisk walking (where feasible), and light-to-moderate aerobic exercises that can be performed at home without specialised equipment. Participants will receive an initial face-to-face training session on how to perform the exercises safely and correctly. They will be encouraged to select exercises according to their preferences, physical abilities, and available time over the 8-week study period. An exercise logbook will be provided to record the date, type, and duration of each exercise session for adherence monitoring.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants will receive usual psychiatric care and routine verbal advice on the benefits of physical activity, including general recommendations such as walking and household physical activities. No structured exercise program, illustrated exercise booklet, supervised exercise instruction, or scheduled exercise follow-up will be provided. Participants will receive an exercise logbook to record any physical activity or exercise performed during the 8-week study period to allow assessment of exercise adherence.",[15],[30,33,36],{"name":31,"affiliation":5,"role":32},"Pazhman Sediqi, Neurologist","STUDY_DIRECTOR",{"name":34,"affiliation":5,"role":35},"Sodaba Rahraw, MD","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":5,"role":38},"Nommanudien Naibkhil, Pharm. D.","STUDY_CHAIR",[40],{"name":37,"role":41,"phone":42,"phoneExt":25,"email":43},"CONTACT","+93786785956","n.naibkhil@gmail.com",{"type":35,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Nommanudien Naibkhil","Head of Research Department","100650177","exercise-adherence-in-afghan-women-with-depression-100650177",false,"NCT07745777","Exercise Adherence in Afghan Women With Depression","A Randomized Controlled Trial Comparing Exercise Adherence Between a Structured Culturally Adapted Home-Based Exercise Program and Routine Exercise Advice Among Afghan Women With Depression","Inclusion Criteria:\n\n* Female participants who self-identify as women.\n* Age 18 to 50 years.\n* Able to read and understand the study information (at least school graduate).\n* Diagnosis of mild to moderate depression according to DSM-5 criteria.\n* Medically able to participate in moderate physical activity.\n* Willing to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Severe depression requiring hospitalization.\n* Psychotic disorders.\n* Bipolar disorder.\n* Severe cardiovascular disease or respiratory disease limiting exercise participation.\n* Musculoskeletal conditions preventing participation in exercise.\n* Pregnancy-related conditions restricting physical activity.\n* Cognitive impairment affecting the ability to provide informed consent.\n* Regular exercise habits before enrolment.","FEMALE","18 Years","50 Years",{"count":58,"type":59},60,"ESTIMATED","INTERVENTIONAL",[62],"NA","The goal of this clinical trial is to learn whether a structured, culturally adapted home-based exercise program helps Afghan women with depression stay more active than routine exercise advice. The study will also examine whether taking part in the exercise program improves depression symptoms, daily functioning, and participant satisfaction, and whether the program is safe.\n\nThe main questions the study aims to answer are:\n\n* Does a structured home-based exercise program help participants exercise more regularly over 8 weeks?\n* Does the program improve depression symptoms and daily functioning?\n* Is the program acceptable to participants, and are there any safety concerns?\n\nResearchers will compare a structured home-based exercise program with routine exercise advice to see which approach leads to better exercise adherence.\n\nAbout 60 women aged 18 to 50 years with mild to moderate depression will take part. Participants will be randomly assigned (by chance) to one of two groups.\n\nParticipants in the structured exercise group will:\n\n* Receive an illustrated exercise booklet with simple home-based exercises, such as breathing, stretching, walking, and light aerobic activities.\n* Choose exercises that suit their preferences, abilities, and daily schedules.\n* Record each exercise session in a logbook, including the date, type of exercise, and how long they exercised.\n\nParticipants in the routine exercise advice group will:\n\n* Receive their usual psychiatric care and general advice about the benefits of physical activity.\n* Receive a logbook to record any physical activity or exercise they complete during the study.\n\nAll participants will take part in the study for 8 weeks. At the beginning and end of the study, they will complete questionnaires about their depression symptoms and their ability to carry out everyday activities. At the end of the study, participants will also complete a questionnaire about their satisfaction with the program, and researchers will ask about any medical problems or injuries that occurred during the study.\n\nThe information from this study may help researchers understand whether a culturally adapted home-based structured exercise program is a practical and effective way to support Afghan women with depression and encourage regular physical activity.",[65],"Depression Disorder",[67,68,69,70,71,72,73,74,75,76,77,78],"depression","Exercise adherence","Physical activity","Home-based exercise","Culturally adapted exercise","Behavioral intervention","Afghan women","Women's mental health","Exercise therapy","Mental health","Randomized controlled trial","Outpatient psychiatry","NOT_YET_RECRUITING","2026-08-03",{"date":82,"type":83},"2026-08-04","ACTUAL",{"date":85,"type":59},"2026-09-01",{"date":87,"type":59},"2026-11-30",{"name":5,"class":6}]