[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610213":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":27,"locations":36,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"City of Hope Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1 - Control",null,"0 or less than 1 day per week, with each session, on average \\\u003C 15 minutes.",[13],"Behavioral: Control",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2 - Exercise","\\>\u002F= 2 days per week of moderate or vigorous intensity, with each session, on average, \\>\u002F=20 minutes in duration.",[18],"Behavioral: Exercise",[20,24],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":10},"BEHAVIORAL","Control",[9],{"type":21,"name":25,"description":16,"armGroupLabels":26,"otherNames":10},"Exercise",[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Lee W Jones, PhD","CONTACT","626-218-3844","leejones@coh.org",{"name":34,"role":30,"phone":31,"phoneExt":10,"email":35},"Lennie Wong, PhD","lenniewong@coh.org",[37],{"facility":5,"status":10,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":10},"Duarte","California","91010","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-117.97729,34.13945,{"lat":47,"lon":46},{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100610213","exercise-and-mortality-in-middle-aged-and-older-adults-100610213",false,"NCT07224659","Exercise and Mortality in Middle-Aged and Older Adults","Exercise and Mortality in Middle-Aged and Older Adults: A Target Trial Emulation","* Adults enrolled into the PLCO screening trial.\n* Among participants reporting low exercise at Q0 (i.e., 0 or less than 1 day\u002Fweek, with each session \\\u003C15 minutes in duration), completion of an exercise survey at Q1 as part of PLCO standard trial procedures no later than 5 years after reporting non-exercising status \\[i.e., no exercise) at Q0.\n* No evidence of any of the following absolute contraindications to exercise: uncontrolled hypertension, symptomatic valvular disease; hypertrophic cardiomyopathy; unstable angina pectoris; primary pulmonary hypertension; heart failure; severe arrhythmia; diagnosed dementia; any form of cancer other than non-melanoma, and severe infectious disease.","ALL","55 Years","74 Years",{"count":62,"type":63},19000,"ESTIMATED","OBSERVATIONAL","This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).",[67],"Overall Survival (All-cause Mortality)","NOT_YET_RECRUITING","2026-08-18",{"date":71,"type":72},"2026-08-19","ACTUAL",{"date":74,"type":63},"2026-10-01",{"date":76,"type":63},"2026-12-01",{"name":5,"class":6},1]