[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649189":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":18,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":18,"enrollmentInfo":62,"targetDuration":18,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":18,"overallStatus":72,"whyStopped":18,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Intervention Group","EXPERIMENTAL","A 12-week structured exercise intervention program consisting of two components: (1) Health education ; (2) Exercise intervention. The intervention is delivered by trained exercise specialists and supervised by the research team. Participants receive exercise diaries to record adherence.",[13],"Behavioral: \"Exercise for Muscle Health\" Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","Participants receive routine rehabilitation care for breast cancer survivors, including: (1) Health education: provision of a breast cancer rehabilitation knowledge booklet covering lymphedema prevention, balanced diet, and weight management; (2) General physical activity advice: recommendation to engage in at least 150 minutes of moderate-intensity aerobic exercise (such as walking) per week, without provision of structured exercise prescriptions, standardized exercise instruction, intensity monitoring, or regular supervision.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","\"Exercise for Muscle Health\" Program","Participants receive routine rehabilitation care for breast cancer survivors, including: (1) provision of a breast cancer rehabilitation knowledge booklet covering lymphedema prevention, balanced diet, and weight management; (2) general physical activity advice recommending at least 150 minutes of moderate-intensity aerobic exercise (such as walking) per week, without structured exercise prescriptions, standardized instruction, intensity monitoring, or regular supervision.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Jun-E Liu, Prof.","CONTACT","+86 18500136128","liujune66@ccmu.edu.cn",[32],{"facility":33,"status":18,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"The Fifth Medical Center of Chinese PLA General Hospital (South Campus)","Beijing","Beijing Municipality","100054","China","CN",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":29,"phoneExt":18,"email":30},"Jun-E Liu, Doctor",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Xiao-qin Su","Principal Investigator of the Study","100649189","exercise-intervention-for-breast-cancer-patients-with-sarcopenia-100649189",false,"NCT07732101","Exercise Intervention for Breast Cancer Patients With Sarcopenia","Development and Evaluation of an Exercise Intervention Program for Breast Cancer Patients With Sarcopenia During Rehabilitation","EX-BCSarc","Inclusion Criteria:\n\nFemale, aged ≥18 years;\n\nPathologically confirmed diagnosis of breast cancer, having completed primary treatment (surgery, chemotherapy, radiotherapy, etc.) and currently in the rehabilitation phase (≥3 months after treatment completion);\n\nMeet sarcopenia diagnostic criteria assessed by trained researchers: for women aged ≥65 years, ASMI \\\u003C 0.57 and handgrip strength \\\u003C 18 kg; for women aged \\\u003C64 years, ASMI \\\u003C 0.63 and handgrip strength \\\u003C 20 kg;\n\nProvide informed consent and voluntarily participate in the study;\n\nHave basic communication and comprehension abilities.\n\nExclusion Criteria:\n\nHistory of psychiatric disorders or consciousness impairment;\n\nPresence of exercise contraindications including severe cardiac, hepatic, or renal insufficiency, bone metastases, or uncontrolled hypertension;\n\nMajor surgery or severe trauma within the past 3 months;\n\nInvoluntary weight loss \\>5% within the past 3 months, or presence of active progressive tumor burden (e.g., imaging evidence of significant metastasis or receiving palliative chemotherapy), suggesting tumor-driven cachexia;\n\nCurrently participating in other exercise intervention studies or having completed other exercise programs within the past 6 months;\n\nRefusal of randomization.","ALL","18 Years",{"count":63,"type":64},104,"ESTIMATED","INTERVENTIONAL",[67],"NA","Sarcopenia is a common yet underrecognized complication in breast cancer survivors during rehabilitation, characterized by loss of muscle mass, reduced muscle strength, and impaired physical function, which adversely affects quality of life and long-term outcomes. Exercise has been identified as a promising non-pharmacological intervention for sarcopenia; however, evidence-based exercise programs specifically tailored for breast cancer patients with sarcopenia remain limited.\n\nThis study aims to develop and evaluate a 12-week exercise intervention program (\"Exercise for Muscle Health\") for breast cancer patients with sarcopenia during rehabilitation. A randomized controlled trial will be conducted to assess the effectiveness of the intervention. A total of 104 eligible participants will be randomly assigned in a 1:1 ratio to either the intervention group or the control group. The intervention group will receive a 12-week structured exercise program combined with health education, while the control group will receive routine rehabilitation care with general physical activity recommendations.\n\nThe primary outcomes include changes in appendicular skeletal muscle mass index (ASMI), handgrip strength, Short Physical Performance Battery (SPPB) score, and physical fitness (2-Minute Step Test and 30-second Chair-Stand Test). Secondary outcomes include sarcopenia-related knowledge, cancer self-efficacy, social support, anxiety, fatigue, and quality of life. Assessments will be conducted at baseline (T0), mid-intervention (week 6, T1), immediately post-intervention (week 12, T2), and 3 months post-intervention (T3).\n\nThe hypothesis is that the 12-week \"Exercise for Muscle Health\" program will significantly improve muscle mass, muscle strength, and physical function compared to routine care, and will be feasible, acceptable, and safe for breast cancer patients with sarcopenia during rehabilitation.",[70,71],"Sarcopenia","Breast Cancer","NOT_YET_RECRUITING","2026-07-23",{"date":75,"type":76},"2026-07-28","ACTUAL",{"date":78,"type":64},"2026-09-01",{"date":80,"type":64},"2027-04-20",{"name":5,"class":6},1]