[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553023":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":54,"centralContacts":59,"locations":65,"responsibleParty":82,"collaborators":45,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":45,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":45,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":68,"whyStopped":45,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,15,21,27],{"label":9,"type":10,"description":11,"interventionNames":12},"Nitrate-Rich Beetroot Juice + High Intensity Exercise (HIE)","EXPERIMENTAL","Participants assigned to this group will be instructed to consume 1 bottle of nitrate-rich beetroot juice (\\~400mg of nitrate each) 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 15-17 based on the participant's VO2peak test.",[13,14],"Dietary Supplement: Nitrate-Rich Beetroot Juice","Behavioral: High Intensity Exercise",{"label":16,"type":17,"description":18,"interventionNames":19},"Nitrate-Depleted Placebo Beetroot Juice + High Intensity Exercise (HIE)","PLACEBO_COMPARATOR","Participants assigned to this group will be instructed to consume 1 bottle of nitrate-depleted beetroot juice 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 15-17 based on the participant's VO2peak test.",[14,20],"Dietary Supplement: Nitrate-Depleted Placebo Beetroot Juice",{"label":22,"type":23,"description":24,"interventionNames":25},"Nitrate-Rich Beetroot Juice + Moderate Intensity Exercise (MIE)","ACTIVE_COMPARATOR","Participants assigned to this group will be instructed to consume 1 bottle of nitrate-rich beetroot juice (\\~400mg of nitrate each) 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 10-12 based on the participant's VO2peak test.",[13,26],"Behavioral: Moderate Intensity Exercise",{"label":28,"type":17,"description":29,"interventionNames":30},"Nitrate-Depleted Placebo Beetroot Juice + Moderate Intensity Exercise (MIE)","Participants assigned to this group will be instructed to consume 1 bottle of nitrate-depleted beetroot juice 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 10-12 based on the participant's VO2peak test.",[26,20],[32,40,46,50],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DIETARY_SUPPLEMENT","Nitrate-Rich Beetroot Juice","subjects will consume 1 bottle of nitrate-rich beetroot juice (\\~400mg of nitrate each) 2x a day",[9,22],[38,39],"Inorganic Nitrate","James White Beet It",{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"BEHAVIORAL","High Intensity Exercise","exercise at an intensity midway between the lactate threshold and VO2peak, from the screening test at an RPE of \\~ 15-17",[16,9],null,{"type":41,"name":47,"description":48,"armGroupLabels":49,"otherNames":45},"Moderate Intensity Exercise","exercise at the RPE at LT associated an \\~ RPE of 10-12",[28,22],{"type":33,"name":51,"description":52,"armGroupLabels":53,"otherNames":45},"Nitrate-Depleted Placebo Beetroot Juice","Subjects will consume 1 bottle of nitrate-depleted beetroot juice 2x a day",[16,28],[55],{"name":56,"affiliation":57,"role":58},"Jason Allen, PhD","UVA","PRINCIPAL_INVESTIGATOR",[60],{"name":61,"role":62,"phone":63,"phoneExt":45,"email":64},"Macy Stahl","CONTACT","434-924-1655","mes4hm@uvahealth.org",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Student Health and Wellness Building - Department of Kinesiology","RECRUITING","Charlottesville","Virginia","22903","United States","US",{"type":75,"coordinates":76},"Point",[77,78],-78.47668,38.02931,{"lat":78,"lon":77},[81],{"name":61,"role":62,"phone":63,"phoneExt":45,"email":64},{"type":58,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"Jason Allen","Professor","100553023","exercise-training-intensity-and-nitrate-supplementation-in-post-menopausal-females-100553023",false,"NCT06480695","Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females","Effects of Exercise Training Intensity and Inorganic Nitrate Supplementation on Vascular Health and Fitness in Post-Menopausal Females","Inclusion Criteria:\n\n* Post-menopausal female (greater than age 45 but less than age 75)\n* Sedentary (does not exercise regularly or less than 2 bouts of exercise per week)\n* No major changes in medication in the last 3 months\n\nExclusion Criteria:\n\n* Smokers within last 5 years\n* Weight unstable (loss\u002Fgain of more than 3kg in the past 3 months)\n* Any medical condition that prevents the subject from exercising safely\n* Hormone replacement therapy (current or within last 3 months)\n* Diabetes\n* Currently or recently on vasoactive medications (i.e., calcium channel blockers, statins, ACE or renin inhibitors, ARBs, nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, etc.)\n* Oral antibiotic use within previous four weeks\n* Oral disease or poor oral health as determined by the Oral Health Questionnaire\n* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use",true,"FEMALE","45 Years","75 Years",{"count":97,"type":98},40,"ESTIMATED","INTERVENTIONAL",[101],"NA","Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an intensity dependent manner. The effects of nitrate supplementation and exercise training over a longer training program remains unexplored. This investigation will examine the impact of exercise training intensity with and without inorganic nitrate supplementation, on CVD and fitness outcomes. Postmenopausal females will be tested for maximal oxygen uptake and lactate threshold before randomization to one of four groups: that inorganic nitrate-rich beetroot juice, or beetroot juice with nitrate extracted; and assigned to one-month of calorie matched high-intensity or moderate-intensity exercise training. Vascular function and fitness will be evaluated before and after training.",[104],"Menopause",[38,104,42,106],"Vascular Health","2026-07-15",{"date":109,"type":110},"2026-07-17","ACTUAL",{"date":112,"type":110},"2025-07-01",{"date":114,"type":98},"2026-12-31",{"name":5,"class":6},1]