[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656896":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":19,"studyPopulation":20,"armGroups":21,"interventions":16,"overallOfficials":25,"centralContacts":29,"locations":16,"responsibleParty":37,"collaborators":16,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":16,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":16,"studyType":54,"phases":16,"briefSummary":55,"conditions":56,"keywords":16,"overallStatus":58,"whyStopped":16,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":16},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Motherhood\u002FPregnancy Choice and Worries Questionnaire (MPWQ) score","The Motherhood\u002FPregnancy Choice and Worries Questionnaire (MPWQ) will be used to assess women's experiences, choices, and worries related to motherhood and pregnancy in the context of multiple sclerosis, including concerns about pregnancy, motherhood, fertility, breastfeeding, childcare, and the potential effects of MS on reproductive decisions. The outcome will be reported as the total MPWQ score according to the scoring instructions of the instrument. The minimum and maximum possible scores and the direction of interpretation will be reported according to the validated version used in this study.","At baseline (during the study interview)",{"measure":14,"description":15,"timeFrame":12},"Reproductive Concerns Scale score","The Reproductive Concerns Scale will be used to assess reproductive concerns related to multiple sclerosis, including concerns about fertility, pregnancy, maternal and fetal health, disease-related risks, treatment-related reproductive issues, and future reproductive plans. The outcome will be reported as the total Reproductive Concerns Scale score according to the scoring instructions of the instrument. The minimum and maximum possible scores and the direction of interpretation will be reported according to the validated version used in this study.",null,{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":6,"timePerspective":18,"maskingInfo":16},"CROSS_SECTIONAL","Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system that predominantly affects individuals during their reproductive years. The increasing availability of effective disease-modifying therapies and improvements in the management of MS have allowed many women living with MS to consider marriage, pregnancy, and parenthood. However, reproductive decision-making may remain complex because women may have concerns about disease progression, disability, pregnancy and postpartum disease activity, effects of medications on pregnancy and breastfeeding, possible health risks to the child, and their ability to fulfil maternal and family responsibilities.\n\nReproductive decisions among women with MS may also be influenced by factors beyond the clinical characteristics of the disease. These may include age, marital status, educational and socioeconomic circumstances, family and social expectations, partner support, reproductive autonomy, previous reproductive experiences, access to appropriate counseling, and perceptions of the impact of MS on family life. Women may therefore make reproductive decisions within a complex interaction of medical, psychological, interpersonal, social, and demographic factors.\n\nDespite the importance of reproductive health in women with chronic diseases, there is limited information about how women with MS in Egypt experience and make reproductive decisions, particularly within the social and cultural context of Upper Egypt. Understanding women's perspectives is important for identifying unmet reproductive health needs and improving counseling and support provided by healthcare professionals.\n\nThis study will use a sequential explanatory mixed-methods approach to explore reproductive decision-making among women of reproductive age living with MS in Assiut Governorate. The study will initially collect quantitative information from eligible married women with MS. The quantitative component will assess reproductive decision-making and related factors, including reproductive intentions and preferences, reproductive autonomy, partner support, and relevant sociodemographic and disease-related characteristics.\n\nThe quantitative findings will subsequently inform the qualitative component. In-depth interviews will be conducted with selected women with MS to provide a deeper understanding of the experiences, concerns, perceptions, and contextual factors underlying reproductive decisions. Married women participating in the quantitative component may be invited to participate in the qualitative interviews. Single women will be explored separately through the qualitative component to capture their perspectives regarding marriage, fertility intentions, future childbearing, and concerns related to reproductive life that cannot be adequately assessed through the quantitative component.\n\nThe qualitative sampling will use purposive maximum-variation sampling to include women with diverse sociodemographic, marital, and disease-related characteristics. These may include age, residence, educational level, employment, disease duration, disability severity, disease-modifying treatment, fertility intentions, motherhood status, and pregnancy experience after MS diagnosis. Interviews will continue until sufficient depth and diversity of information are achieved and thematic saturation is reached.\n\nThe qualitative interviews will explore women's experiences of living with MS and its perceived influence on marriage and intimate relationships, fertility intentions and timing of childbearing, desired family size, pregnancy and childbirth, breastfeeding, motherhood and childcare, and family planning and contraceptive decision-making. Participants will also be asked about their experiences of receiving reproductive health counseling and information related to pregnancy, contraception, breastfeeding, MS treatment, and potential risks to themselves or their children. The interviews will further explore the roles of partners, families, healthcare professionals, and the broader social context in shaping reproductive decisions.\n\nQuantitative and qualitative findings will be interpreted together to develop a comprehensive understanding of reproductive decision-making among women living with MS. The qualitative findings will help explain and contextualize important quantitative patterns and may identify experiences or factors that are not captured by structured questionnaires.\n\nThe study is intended to generate evidence about the reproductive concerns, needs, and decision-making experiences of women living with MS in Assiut Governorate. The findings may help identify gaps in reproductive health information and counseling and may support the development of more responsive, patient-centered reproductive health services for women with MS. The study may also provide a basis for future research and interventions addressing reproductive health and family planning needs among women living with chronic neurological diseases.","The quantitative study population will include married women aged 18-49 with confirmed multiple sclerosis who attend the selected study sites during the study period. On the other hand, the qualitative population will include single, currently married, divorced and widowed\u002Fever-married women aged 18-49 years with confirmed MS, as appropriate to the study sites and the qualitative sampling plan.",[22],{"label":23,"type":16,"description":24,"interventionNames":16},"The quantitative study population will include married women aged 18-49 with confirmed MS","The quantitative study population will include married women aged 18-49 with confirmed multiple sclerosis who attend the selected study sites during the study period. On the other hand, the qualitative population will include single, currently married, divorced, or widowed\u002Fever-married women aged 18-49 years with confirmed MS, as appropriate to the study sites and the qualitative sampling plan.\n\nEligibility criteria:\n\n* Inclusion criteria Women who are\n\n  * Within the reproduct age group (18-49 years).\n  * With a confirm diagnosis of multiple sclerosis according to the 2024 Revised McDonald Criteria (31).\n  * Able to communicate, agree to participate in the study and provide informed consent.\n* Exclusion Criteria\n\nWomen with:\n\n* Severe cognitive impairment or psychiatric illness affects their ability to participate in the study.\n* Acute medical or neurological deterioration at the time of recruitment makes participation inappropriate or burdensome.\n* Any condition judged by the clinical team or",[26],{"name":27,"affiliation":5,"role":28},"Prof. Dr. Etemad El-shereef, professor","STUDY_DIRECTOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":16,"email":34},"Doneez Amir Eskander","CONTACT","+201220225678","doneez.amir@aun.edu.eg",{"name":36,"role":32,"phone":16,"phoneExt":16,"email":16},"Doaa Mohamed Osman, assistant professor",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"PRINCIPAL_INVESTIGATOR","Doneez Amir Adly Eskander","Assistant Lecturer","100656896","exploring-reproductive-decision-making-among-women-with-multiple-sclerosis-100656896",false,"NCT07829822","Exploring Reproductive Decision-Making Among Women With Multiple Sclerosis","Exploring Reproductive Decision-Making Among Women With Multiple Sclerosis in Assiut Governorate: Mixed-Methods Study","o Inclusion criteria\n\nWomen who are:\n\n* Within reproductive age group (18-49 years).\n* With confirmed diagnosis of multiple sclerosis according to the 2024 Revised McDonald Criteria (31).\n* Able to communicate, agree to participate in the study and provide informed consent.\n\n  * Exclusion Criteria\n\nWomen with:\n\n* Severe cognitive impairment or psychiatric illness affects their ability to participate in the study.\n* Acute medical or neurological deterioration at the time of recruitment makes participation inappropriate or burdensome.\n* Any condition judged by the clinical team or research team to make participation unsafe or to compromise the validity of the interview.","FEMALE","18 Years","49 Years",{"count":52,"type":53},272,"ESTIMATED","OBSERVATIONAL","Multiple sclerosis (MS) is a chronic disease that mainly affects young adults, including women during their reproductive years. Women with MS may face important questions and concerns related to marriage, fertility, pregnancy, childbirth, breastfeeding, motherhood, and family planning. These decisions may be influenced by concerns about MS symptoms and disability, pregnancy-related changes in the disease, medications, possible effects on the baby, and the availability of appropriate reproductive health counseling and support.\n\nThis study aims to explore reproductive decision-making among women of reproductive age living with multiple sclerosis in Assiut Governorate, Egypt. The study will examine their experiences, concerns, fertility intentions, childbearing preferences, family planning practices, and experiences related to marriage, pregnancy, breastfeeding, and motherhood. It will also assess factors that may influence reproductive decisions, including disease-related characteristics, social and demographic factors, reproductive autonomy, and partner support among married women.\n\nThe study will use a sequential explanatory mixed-methods design. The quantitative component will include eligible married women with multiple sclerosis attending selected multiple sclerosis clinics in Assiut Governorate. Information will be collected through face-to-face interviews using structured questionnaires and validated assessment tools. The quantitative findings will be used to identify important patterns and factors associated with reproductive decision-making.\n\nA qualitative component will then be conducted through in-depth interviews with selected women with multiple sclerosis to provide a deeper understanding of their experiences and concerns. Single women will be explored qualitatively to understand their perspectives regarding marriage, fertility, and future reproductive plans, while married women who participate in the quantitative component may also be invited for qualitative interviews. Participants will be selected to obtain a range of experiences and characteristics, and interviews will continue until sufficient information is obtained.\n\nThe study will provide a better understanding of the reproductive needs and concerns of women living with multiple sclerosis in Assiut Governorate. The findings may help identify gaps in reproductive health counseling and support and may contribute to the development of more patient-centered reproductive health services for women with multiple sclerosis",[57],"Multiple Sclerosis","NOT_YET_RECRUITING","2026-09-18",{"date":61,"type":62},"2026-09-21","ACTUAL",{"date":64,"type":53},"2027-06-01",{"date":66,"type":53},"2031-10-01",{"name":5,"class":6}]