[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645503":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":26,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":26,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":67,"whyStopped":26,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":26},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Eye-Movement Intervention Group","EXPERIMENTAL","Participants in this group will receive a gamified eye-movement intervention targeting fixation control, smooth pursuit, and saccadic eye movements. The training is delivered through interactive game-based tasks including fixation-based jumping, directional gaze control, and gaze-guided visual tracking. Participants will complete 3-4 sessions per week, with each session lasting approximately 30 minutes, for a total intervention period of 4 weeks. The intervention aims to improve visuospatial attention and cognitive performance.",[13],"Behavioral: Eye-Movement Training",{"label":15,"type":16,"description":17,"interventionNames":18},"Active Control Group (Finger-Controlled Game Training)","ACTIVE_COMPARATOR","Participants in this group will receive a finger-controlled gamified training program matched in duration, frequency, visual stimulation, and task structure to the experimental intervention. The training does not involve eye-movement control and serves as an active control condition to account for non-specific effects such as task engagement, visual exposure, and expectancy. Participants will complete 3-4 sessions per week, each lasting approximately 30 minutes, over a 4-week period.",[19],"Behavioral: Finger-Controlled Game Training",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Eye-Movement Training","A gamified eye-movement training program designed to improve fixation control, smooth pursuit, and saccadic eye movements. The intervention includes three interactive tasks: fixation-based jumping game, gaze-direction control game, and gaze-guided visual tracking game. Participants complete 3-4 sessions per week, approximately 30 minutes per session, for 4 weeks. The intervention is delivered via a computerized eye-tracking system.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Finger-Controlled Game Training","A gamified finger-controlled training program matched in duration, frequency, visual stimulation, and task structure to the eye-movement intervention. Participants control game actions using finger inputs instead of eye movements. The intervention is designed as an active control to account for non-specific effects including engagement, visual exposure, and task expectancy. Participants complete 3-4 sessions per week, approximately 30 minutes per session, for 4 weeks.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Tianhong Zhang, MD","CONTACT","86-21-3477 3065","zhang_tianhong@126.com",{"type":38,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100645503","eye-movement-intervention-for-cognitive-impairment-across-schizophrenia-spectrum-100645503",false,"NCT07702526","Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum","Effects of an Eye-Movement Intervention on Cognitive Impairment in Individuals Across Illness Stages of Schizophrenia: Protocol for a Stratified Randomized, Active-Controlled, Assessor-Blinded Trial","Inclusion Criteria:\n\n* Age between 15 and 45 years.\n* More than 9 years of education.\n* Normal or corrected-to-normal vision without color blindness, color weakness, strabismus, or nystagmus.\n* Right-handedness.\n* Impaired cognitive performance defined as a T-score \\\u003C40 in at least one MCCB cognitive domain at baseline.\n* Capacity to complete cognitive and eye-tracking assessments.\n* Clinical high-risk group: Meet psychosis-risk syndrome criteria based on SIPS\u002FSOPS, including attenuated positive symptoms or brief intermittent psychotic symptoms.\n* First-episode schizophrenia group: Meet DSM-5 criteria for schizophrenia, with first episode occurring within approximately 2 years of illness onset and minimal prior antipsychotic exposure.\n* Chronic schizophrenia group: Meet DSM-5 criteria for schizophrenia, with illness duration ≥5 years and stable treatment status for the previous 6 months.\n* Healthy control group: No current or past psychiatric disorders based on MINI 7.0 and no significant depressive symptoms based on the Hamilton Depression Rating Scale. Healthy controls will also meet the same general criteria regarding age, education, handedness, and vision.\n\nExclusion Criteria:\n\n* IQ \\\u003C70.\n* Severe or unstable medical or neurological illness (e.g., stroke, epilepsy, dementia, cardiac disease, or uncontrolled hypertension).\n* Substance abuse or dependence.\n* Clinically significant laboratory abnormalities.\n* Visual or auditory impairments affecting task performance.",true,"ALL","15 Years","45 Years",{"count":51,"type":52},160,"ESTIMATED","INTERVENTIONAL",[55],"NA","The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode schizophrenia patients, and chronic schizophrenia patients. The main questions it aims to answer are:\n\n* Does eye-movement training improve cognitive performance measured by the MATRICS Consensus Cognitive Battery (MCCB)?\n* Does eye-movement training improve oculomotor functions and clinical symptoms across different illness stages?\n\nResearchers will compare an eye-movement intervention group with an active control group receiving matched finger-controlled game training to determine whether the eye-movement intervention produces greater improvements in cognitive function and eye-movement performance.\n\nParticipants will:\n\n* Receive either gamified eye-movement training or matched finger-controlled game training for 4 weeks.\n* Complete cognitive assessments using the MCCB before and after the intervention.\n* Complete standardized eye-tracking tasks, including fixation stability, smooth pursuit, antisaccade, and free-viewing tasks, to evaluate changes in oculomotor control and visual exploration patterns.\n* Complete clinical symptom assessments using SOPS or PANSS according to illness stage.",[58,59,60],"Schizophrenia","Cognitive Impairment","Clinical High Risk for Psychosis",[62,63,64,65,66],"Eye movement training","Cognitive remediation","BVMT-R","Visuospatial memory","Eye tracking","NOT_YET_RECRUITING","2026-07-08",{"date":70,"type":71},"2026-07-14","ACTUAL",{"date":73,"type":52},"2026-07-01",{"date":75,"type":52},"2028-07-30",{"name":5,"class":6}]