[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651915":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":27,"collaborators":20,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":20,"enrollmentInfo":40,"targetDuration":20,"studyType":43,"phases":44,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":55,"whyStopped":20,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":20},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Multimodal Postoperative Rehabilitation","EXPERIMENTAL","Participants will receive a 4-week intensive multimodal postoperative rehabilitation program starting during the first week after hospital discharge. The program includes individualized exercise training, nutritional therapy, and anxiety-reducing techniques, tailored to each participant's clinical, physical, nutritional, and psychological condition. Exercise training will be delivered either in a supervised hospital-based setting or through a home-based program according to patient preference and availability. All participants will receive the multimodal rehabilitation program in addition to standard care",[13],"Behavioral: Multimodal Postoperative Rehabilitation Program",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Multimodal Postoperative Rehabilitation Program","Participants will undergo a 4-week multimodal postoperative rehabilitation program starting during the first week after hospital discharge. The program includes individualized exercise training, nutritional therapy, and anxiety-reducing techniques. Exercise includes moderate-intensity endurance, resistance, and breathing exercises tailored to the patient's clinical condition and may be delivered in a hospital-based or home-based setting. Nutritional therapy consists of an individualized dietary plan, with a recommended protein intake of 1.5-2.0 g\u002Fkg of ideal body weight and whey protein supplementation if needed. Participants will also receive instruction in relaxation techniques, including imagery, visualization, and deep-breathing exercises. The program is delivered by qualified physiotherapists, nutritionists, and psychology-trained personnel.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Nicolò pecorelli","CONTACT","0226437810","pecorelli.nicolo@hsr.it",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Nicolò Pecorelli","Assistant Professor","100651915","feasibility-of-a-4-week-intensive-postoperative-multimodal-rehabilitation-program-in-complicated-patients-after-proximal-pancreatectomy-a-prospective-single-cohort-study-100651915",false,"NCT07768384","Feasibility of a 4-Week Intensive Postoperative Multimodal Rehabilitation Program in Complicated Patients After Proximal Pancreatectomy: A Prospective Single-Cohort Study","REACT","* Inclusion Criteria:\n* Age ≥18 years.\n* Patients undergoing elective proximal pancreatic resection (pancreatoduodenectomy or total pancreatectomy).\n* Patients developing a severe postoperative complication during their hospital stay, defined as a Comprehensive Complication Index (CCI) \\>21.\n* Exclusion Criteria:\n* Metastatic disease.\n* Surgical procedures other than pancreatoduodenectomy or total pancreatectomy.\n* Inability to speak Italian.\n* Cognitive impairment or illiteracy resulting in inability to read and understand the Italian language.\n* Medical conditions contraindicating the rehabilitation regimen (exercise and nutritional intervention), including orthopedic or cognitive disabilities and chronic renal failure (dialysis or creatinine \\>250 mmol).\n* Pregnancy.","ALL","18 Years",{"count":41,"type":42},40,"ESTIMATED","INTERVENTIONAL",[45],"NA","The REACT study is a prospective, single-center, single-cohort study designed to evaluate the feasibility of a 4-week intensive multimodal postoperative rehabilitation program in patients who develop severe complications after proximal pancreatic resection (pancreatoduodenectomy or total pancreatectomy).\n\nPostoperative complications after pancreatic surgery may result in substantial physiological and metabolic stress, leading to loss of muscle mass, malnutrition, reduced functional capacity, and delayed recovery. Although prehabilitation programs have been proposed to improve patients' functional capacity before surgery, evidence regarding structured multimodal rehabilitation after pancreatic surgery is currently lacking.\n\nAdult patients undergoing elective proximal pancreatic resection who develop a severe postoperative complication (Comprehensive Complication Index \\>21) will be eligible for the study. Participants will undergo a 4-week multimodal rehabilitation program starting after hospital discharge and including individualized exercise training, nutritional therapy, and anxiety-reducing techniques. The program may be delivered either in a supervised hospital-based setting or through a home-based program according to patient preference and availability.\n\nThe primary objective is to assess the feasibility of the rehabilitation program in terms of recruitment, adherence, completion of outcome assessments, completeness of data, and safety. Secondary objectives include evaluating postoperative functional recovery using PROMIS-29 Physical and Mental Health Summary Scores, the 6-minute walk test, and the Duke Activity Status Index. In patients with malignancy who are candidates for adjuvant treatment, return to intended oncologic treatment will also be evaluated.\n\nA total of 40 patients will be enrolled and followed for up to 90 days after surgery.",[48],"Pancreatic Diseases",[50,51,52,53,54],"Pancreatic Surgery","Multimodal Rehabilitation","Functional Recovery","Postoperative Rehabilitation","Postoperative Complications","NOT_YET_RECRUITING","2026-08-14",{"date":58,"type":59},"2026-08-17","ACTUAL",{"date":61,"type":42},"2026-09",{"date":63,"type":42},"2028-03-31",{"name":5,"class":6}]