[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552063":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":50,"collaborators":24,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":24,"eligibilityCriteria":58,"healthyVolunteers":55,"sex":59,"minAge":24,"maxAge":60,"enrollmentInfo":61,"targetDuration":24,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":33,"whyStopped":24,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study on Fertility Sparing Therapy in IA Stage G2 Endometrial Cancer Patients","EXPERIMENTAL","Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg\u002Fd or MA 320mg\u002Fd.",[13],"Drug: Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg\u002Fd or MA 320mg\u002Fd.",{"label":15,"type":10,"description":16,"interventionNames":17},"The Study on Fertility Sparing Therapy in IA Stage G2 Endometrial Cancer Patients","Treatment Option 2 is a combination therapy, consisting of oral MPA 500mg\u002Fd\u002FMA 320mg\u002Fd combined with the intrauterine insertion of the levonorgestrel intrauterine system (LNG-IUS, Mirena IUD).",[13],[19],{"type":20,"name":11,"description":21,"armGroupLabels":22,"otherNames":23},"DRUG","Compare the efficacy of mono-therapy with progesterone versus combined therapy to determine the best treatment option.",[9,15],[16],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Yiqin Wang","CONTACT","008688324380","emily_wang92@163.com",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Beijing","Beijing Municipality","100044","China","CN",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46,47],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},{"name":48,"role":49,"phone":24,"phoneExt":24,"email":24},"Jianliu Wang, PhD, MD","PRINCIPAL_INVESTIGATOR",{"type":49,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Wang Jianliu","Deaprtment of Obstetrics and Gynecology","100552063","fertility-sparing-therapy-for-patients-with-stage-ia-g2-endometrial-cancer-100552063",false,"NCT06468215","Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer","Inclusion Criteria:\n\n* Endometrioid adenocarcinoma G2, diagnosis by pathological.\n* The lesion is limited to the endometrium.\n* FIGO (2009) staging is IA.\n* Age less than 45.\n* Strongly request to preserve fertility.\n* Sign informed consent.\n\nExclusion Criteria:\n\n* The tumor has invaded the muscle layer.\n* FIGO (2009) stage IB or higher.\n* Endometrioid adenocarcinoma G1, G3, or non-endometrioid cancer\n* There are malignant tumors in other systems.\n* Have contraindications for conservative treatment or drug use.\n* Have been judged by the researcher to be unsuitable for childbearing.","FEMALE","45 Years",{"count":62,"type":63},16,"ESTIMATED","INTERVENTIONAL",[66],"NA","Endometrial cancer (EC) is a prevalent gynecological cancer with an escalating global incidence and a decreasing age of onset. In the era of precision medicine, there is an increasing emphasis on tailoring treatments to different populations to optimize the positive impact of clinical interventions. Fertility-sparing therapies (FST) are gaining popularity for early-stage, low-grade endometrial cancer due to mounting evidence supporting favorable oncologic and pregnancy outcomes. However, consensus regarding the feasibility of fertility-sparing therapy for similar low-risk grade-2 (G2) endometrioid adenocarcinoma remains elusive. Given the uncertainties surrounding fertility-preserving therapy in patients with moderately differentiated endometrial cancer, this study aims to investigate the optimal regimen of fertility-preserving therapy for patients with IAG2.",[69,70],"Carcinoma, Endometrioid","Fertility Preservation",[72,73,74],"endometrial cancer","fertility-sparing treatment","grade 2","2026-08-19",{"date":77,"type":78},"2026-08-21","ACTUAL",{"date":80,"type":78},"2024-06-21",{"date":82,"type":63},"2028-10",{"name":5,"class":6},1]