[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518391":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":33,"locations":39,"responsibleParty":60,"collaborators":62,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":10,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Kaiser Permanente","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fluad Recipients",null,"Kaiser Permanente Northern California members aged ≥65 years who receive Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4)",[13],"Biological: Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4)",{"label":15,"type":10,"description":16,"interventionNames":17},"Fluzone High-Dose Recipients","Kaiser Permanente Northern California members aged ≥65 years who receive High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4)",[18],"Biological: High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4)",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4)","Fluad Quadrivalent vaccine is an inactivated influenza vaccine formulated to contain 60 mcg of hemagglutinin (HA) total, with 15 mcg from each of the four recommended influenza strains and the MF59 adjuvant in single-dose prefilled 0.5 mL syringes. Kaiser Permanente Northern California members ≥65 years may receive Fluad as part of routine clinical care during the influenza season.",[9],[26],"Fluad",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4)","Fluzone High-Dose Quadrivalent vaccine is an inactivated split virion influenza vaccine formulated to contain 240 mcg of HA total, with 60 mcg from each of the four recommended influenza strains in single-dose prefilled 0.7 mL syringes. Kaiser Permanente Northern California members ≥65 years may receive Fluzone High-Dose as part of routine clinical care during the influenza season.",[15],[32],"Fluzone High-Dose",[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Amber H. Hyman, PhD, MPH","CONTACT","510-267-7571","Amber.Hyman@kp.org",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Kaiser Permanente Northern California (entire region)","RECRUITING","Oakland","California","94612","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-122.2708,37.80437,{"lat":52,"lon":51},[55,57],{"name":35,"role":36,"phone":56,"phoneExt":10,"email":38},"(510) 267-7517",{"name":58,"role":59,"phone":10,"phoneExt":10,"email":10},"Nicola P. Klein, MD, PhD","PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[63],{"name":64,"class":65},"Seqirus","INDUSTRY","100518391","fluad-vs-fluzone-high-dose-vaccine-effectiveness-among-adults-65-years-100518391",false,"NCT06029933","Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years","Relative Vaccine Effectiveness of Adjuvanted Inactivated Influenza Vaccine (aIIV) vs High-Dose Inactivated Influenza Vaccine (HD-IIV) for Prevention of Lab-Confirmed Influenza Among Adults ≥65 Years of Age in the United States","Inclusion Criteria:\n\n* Age ≥65 years at the time of influenza vaccination\n* KPNC member at the time of vaccination\n* Receive either aIIV4 or HD-IIV4 at a KPNC facility during the 2023\u002F24 and\u002For 2024\u002F25 influenza seasons\n\nExclusion Criteria:\n\n* Age \\\u003C65 years at the time of influenza vaccination\n* Received either aIIV4 or HD-IIV4 in the inpatient setting\n* Receive more than one influenza vaccination during a single season period (i.e., 2023\u002F24 or 2024\u002F25 influenza seasons)\n* Receive an influenza vaccination outside of KPNC",true,"ALL","65 Years",{"count":77,"type":78},1500000,"ESTIMATED","OBSERVATIONAL","This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adults ≥65 years of age during the 2023\u002F24, 2024\u002F25, and 2026\u002F27 influenza seasons. The study is an observational study conducted at Kaiser Permanente Northern California (KPNC), an integrated health care system in the United States.",[82,83,84],"Influenza","Community-acquired Pneumonia","Cardiovascular Events","2026-08-03",{"date":87,"type":88},"2026-08-05","ACTUAL",{"date":90,"type":88},"2023-08-17",{"date":92,"type":78},"2028-05",{"name":5,"class":6},1]