[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566142":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":62,"collaborators":64,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Methadone",null,"Participants initiated into methadone within the past 6 months will receive fMRI and cognitive assessment battery.",[13],"Diagnostic Test: fMRI",{"label":15,"type":10,"description":16,"interventionNames":17},"Buprenorphrine","Participants initiated into buprenorphine within the past 6 months will receive fMRI and cognitive assessment battery.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","fMRI","Participants will be performing tasks while undergoing fMRI. Tasks include Stroop task, Emotion-regulation task and an Ambiguity reward task, Drug cue task, and Cognitive behavioral therapy task. Participants are not presented with any specific stimulus.",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Sarah Yip, PhD, MSc","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Monica Holler","CONTACT","203-278-1107","monica.holler@yale.edu",[35,53],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Hartford Healthcare","RECRUITING","Hartford","Connecticut","06102","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-72.68509,41.76371,{"lat":47,"lon":46},[50,51],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":52,"role":27,"phone":10,"phoneExt":10,"email":10},"Vaughn Steele",{"facility":54,"status":37,"city":55,"state":39,"zip":56,"country":41,"countryCode":42,"cosmosGeoPoint":57,"geoPoint":61,"contacts":10},"The APT Foundation","New Haven","06520",{"type":44,"coordinates":58},[59,60],-72.92816,41.30815,{"lat":60,"lon":59},{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[65],{"name":66,"class":67},"National Institute on Drug Abuse (NIDA)","NIH","100566142","fmri-and-opioid-abstinence-100566142",false,"NCT06651333","fMRI and Opioid Abstinence","Functional Connectivity Mechanisms of Opioid Abstinence","Inclusion Criteria:\n\n* recent initiation of methadone or buprenorphine at a clinic, program, or doctor within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);\n* eligibility for MRI scanning;\n* ability to commit to study visits.\n\nExclusion Criteria:\n\n* current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;\n* current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;\n* severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \\\u003C30 (i.e., severe impairment)\n* past or present history of intellectual disability, developmental disorder, or neurological disease;\n* head trauma with loss of consciousness \\>30 min;\n* organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.","ALL","18 Years","50 Years",{"count":79,"type":80},240,"ESTIMATED","OBSERVATIONAL","This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.",[84,85,86,87,88],"Drug Use Disorder","Opioid Dependence","Opioid-Related Disorders","Opioid Use","Opioid Abuse",[90],"Relapse","2026-08-04",{"date":93,"type":94},"2026-08-07","ACTUAL",{"date":96,"type":94},"2024-12-12",{"date":98,"type":80},"2029-11",{"name":5,"class":6},2]