[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647683":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":41,"centralContacts":67,"locations":76,"responsibleParty":93,"collaborators":97,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":41,"eligibilityCriteria":106,"healthyVolunteers":102,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":41,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":122,"overallStatus":79,"whyStopped":41,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"Tzu Chi University","OTHER",[8,13,18,24,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A: Foot Reflexology - True (n=36)","EXPERIMENTAL","Procedure: True Foot Reflexology",[11],{"label":14,"type":15,"description":16,"interventionNames":17},"Arm B: Foot Reflexology - Sham (n=36)","SHAM_COMPARATOR","Procedure: Sham Foot Reflexology",[16],{"label":19,"type":10,"description":20,"interventionNames":21},"Arm C: ta-VNS - True (n=36)","Device: True ta-VNS + Procedure: Auricular Acupressure",[22,23],"Device: True ta-VNS","Procedure: True Auricular Acupressure",{"label":25,"type":15,"description":26,"interventionNames":27},"Arm D: ta-VNS - Sham (n=36)","Device: Sham ta-VNS + Procedure: Sham Auricular Acupressure",[28,29],"Device: Sham ta-VNS","Procedure: Sham Auricular Acupressure",{"label":31,"type":32,"description":33,"interventionNames":34},"Arm E: Usual Care (n=36)","ACTIVE_COMPARATOR","Other: Usual Care",[33],[36,42,46,51,55,59,63],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"PROCEDURE","True Foot Reflexology","Twice weekly, 20 min, over 2 weeks. Three phases: relaxation (diaphragm, brain, spine zones, 3 min); head-neck function and gastrointestinal regulation (upper\u002Flower GI, thyroid, adrenal zones, 10 min); circulation\u002Fdetoxification (kidney, lymphatic zones, 7 min).",[9],null,{"type":37,"name":43,"description":44,"armGroupLabels":45,"otherNames":41},"Sham Foot Reflexology","Light touch on non-specific foot areas without",[14],{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":41},"DEVICE","True ta-VNS","Left tragus, cymba conchae, cavum conchae; 250 µs, 25 Hz, 0.5-5 mA individualized to tingling, 30 s on\u002Foff; twice weekly, 20 min, 2 weeks. Device: Hong-Tai mid-frequency electrotherapy stimulator, model HT66B (TFDA license no. 000637), used off-label for auricular vagus nerve stimulation.",[19],{"type":47,"name":52,"description":53,"armGroupLabels":54,"otherNames":41},"Sham ta-VNS","Left earlobe, 0.5 mA, otherwise identical parameters.",[25],{"type":37,"name":56,"description":57,"armGroupLabels":58,"otherNames":41},"True Auricular Acupressure","Magnetic beads (1-2 mm) at left tragus, cymba conchae, cavum conchae; 3×\u002Fday, \\~30 s per point; changed every 2-3 days.",[19],{"type":37,"name":60,"description":61,"armGroupLabels":62,"otherNames":41},"Sham Auricular Acupressure","Beads at left earlobe (non-vagal regions), same frequency\u002Fduration.",[25],{"type":6,"name":64,"description":65,"armGroupLabels":66,"otherNames":41},"Usual Care","Standard CCRT nursing care, antiemetic medication, side-effect prevention education, and symptom monitoring; no study intervention.",[31],[68,73],{"name":69,"role":70,"phone":71,"phoneExt":41,"email":72},"Yu-Fu Chou MD","CONTACT","886-3-8561825","yufuchou@yahoo.com.tw",{"name":74,"role":70,"phone":41,"phoneExt":41,"email":75},"Chun-Hou Huang","hou2017@gms.tcu.edu.tw",[77],{"facility":78,"status":79,"city":80,"state":41,"zip":81,"country":82,"countryCode":83,"cosmosGeoPoint":84,"geoPoint":89,"contacts":90},"Hualien Tzu Chi Hospital, Department of Otorhinolaryngology","RECRUITING","Hualien City","970","Taiwan","TW",{"type":85,"coordinates":86},"Point",[87,88],121.60444,23.97694,{"lat":88,"lon":87},[91],{"name":92,"role":70,"phone":71,"phoneExt":41,"email":72},"Yu-Fu Chou Chou, MD",{"type":94,"investigatorFullName":95,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"PRINCIPAL_INVESTIGATOR","Chun Hou Huang","Associate Professor",[98],{"name":99,"class":6},"Hualien Tzu Chi General Hospital","100647683","foot-reflexology-and-ta-vns-for-symptom-management-in-head-and-neck-cancer-during-ccrt-100647683",false,"NCT07711626","Foot Reflexology and Ta-VNS for Symptom Management in Head and Neck Cancer During CCRT","Efficacy of Foot Reflexology and Transcutaneous Auricular Vagus Nerve Stimulation on Pain, Xerostomia, Fatigue, Sleep, and Treatment-Related Symptoms in Head and Neck Cancer Patients Receiving Concurrent Chemoradiotherapy: A Randomized, Single-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Pathologically confirmed head and neck cancer, clinical stage II-IVA, age 30-75 years, conscious, able to communicate and comprehend, and able to comply with study procedures\n* Scheduled to receive a second cycle of cisplatin-based concurrent chemoradiotherapy\n* ECOG performance status ≤2\n\nExclusion Criteria:\n\n* Severe cognitive impairment or psychiatric illness precluding comprehension or cooperation\n* Open wounds or skin lesions of the foot or ear, lower-limb edema, history of deep vein thrombosis, or diabetes with most recent HbA1c \\>7.5%\n* Cardiac pacemaker or other implanted electronic device, or other severe cardiovascular disease\n* Severe bone-marrow suppression (WBC \\\u003C2,000\u002FµL or platelets \\\u003C50,000\u002FµL)\n* Pregnant or breastfeeding women\n* History of epilepsy or seizures\n* Physically frail condition","ALL","30 Years","75 Years",{"count":111,"type":112},180,"ESTIMATED","INTERVENTIONAL",[115],"NA","Head and neck cancer (HNC) patients undergoing concurrent chemoradiotherapy (CCRT) frequently experience pain, xerostomia, fatigue, sleep disturbance, and other treatment-related toxicities that impair quality of life and treatment adherence, with incomplete relief from current supportive care. This randomized, single-blind, sham-controlled trial evaluates whether foot reflexology (FR), transcutaneous auricular vagus nerve stimulation (ta-VNS), and auricular acupressure (AA) reduce pain, xerostomia, fatigue, sleep disturbance, and treatment-related symptoms in HNC patients receiving cisplatin-based CCRT, compared with usual care. Participants are randomized to a foot reflexology group, an auricular vagus nerve stimulation group (each with true and sham subgroups), or a usual-care control group, and are followed at baseline and weeks 1, 2, and 4.",[118,119,120,121],"Head and Neck Neoplasms","Xerostomia","Cancer-related Fatigue","Pain",[123,124,125,126,127,128,119,129,121,130],"Foot Reflexology","Transcutaneous Auricular Vagus Nerve Stimulation","ta-VNS","Auricular Acupressure","Head and Neck Cancer","Concurrent Chemoradiotherapy","Cancer-Related Fatigue","Sleep Quality","2026-07-23",{"date":133,"type":134},"2026-07-24","ACTUAL",{"date":136,"type":134},"2026-07-13",{"date":138,"type":112},"2028-12-31",{"name":5,"class":6},1]