[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654615":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":13,"overallOfficials":13,"centralContacts":13,"locations":13,"responsibleParty":22,"collaborators":13,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":13,"eligibilityCriteria":32,"healthyVolunteers":28,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":13,"studyType":39,"phases":13,"briefSummary":40,"conditions":41,"keywords":45,"overallStatus":54,"whyStopped":13,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":13},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Percentage of Participants With Metabolic Acidosis on Admission","Metabolic acidosis is defined based on arterial blood gas (ABG) analysis performed at admission as a serum or arterial bicarbonate concentration less than 22 mmol\u002FL and\u002For a base deficit greater than or equal to 5 mmol\u002FL. The outcome is measured as the percentage of participants meeting these criteria.","Baseline",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Pediatric patients aged 1 month up to 18 years admitted to the Pediatric Intensive Care Unit (PICU) at Assiut University Children Hospital during the study period who undergo arterial blood gas (ABG) analysis upon admission.",[19],{"label":20,"type":13,"description":21,"interventionNames":13},"PICU Cohort","Critically ill pediatric patients aged 1 month up to 18 years admitted to the Pediatric Intensive Care Unit (PICU) who undergo arterial blood gas analysis upon admission. Patients will be evaluated for the presence of metabolic acidosis and followed during their PICU stay to assess clinical outcomes, duration of stay, and mortality.",{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","George Yousry Adeeb Azer","Resident of Pediatrics","100654615","frequency-of-metabolic-acidosis-in-the-pediatric-intensive-care-unit-100654615",false,"NCT07803263","Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit","Frequency of Metabolic Acidosis Among Patients Admitted to Pediatric Intensive Care Unit","Inclusion Criteria:\n\n* Pediatric patients aged 1 month up to 18 years.\n* Admission to the Pediatric Intensive Care Unit (PICU).\n* Arterial blood gas (ABG) analysis performed on admission.\n\nExclusion Criteria:\n\n* Neonates (age \\\u003C 1 month).\n* Readmission during the same hospital admission.\n* Patients with incomplete clinical or laboratory data.\n* Patients discharged or transferred before complete initial clinical and laboratory assessment","ALL","1 Month","1 Year",{"count":37,"type":38},140,"ESTIMATED","OBSERVATIONAL","Metabolic acidosis is one of the most common acid-base disturbances encountered in critically ill children and often reflects underlying disease severity. Despite its clinical importance, prospective epidemiological data regarding its frequency, underlying etiologies, and associated clinical outcomes among pediatric intensive care unit (PICU) admissions in Upper Egypt remain limited.\n\nThe primary objective of this prospective observational cohort study is to determine the frequency of metabolic acidosis among pediatric patients admitted to the Pediatric Intensive Care Unit at Assiut University Children Hospital. Secondary objectives include identifying the common etiologies and types of metabolic acidosis, as well as evaluating its relationship with clinical outcomes such as mortality, duration of PICU stay, need for mechanical ventilation, and requirement for vasoactive support.\n\nA total of 140 eligible pediatric patients aged 1 month to 18 years admitted to the PICU will be enrolled. Eligible patients will undergo arterial blood gas (ABG) analysis and standard clinical and laboratory evaluations upon admission. Metabolic acidosis will be defined based on admission ABG criteria (serum\u002Farterial bicarbonate \\\u003C 22 mmol\u002FL and\u002For base deficit ≥ 5 mmol\u002FL). Patients will be monitored throughout their hospital stay to assess clinical outcomes without interfering with routine medical management.",[42,43,44],"Metabolic Acidosis","Acid-Base Imbalance","Critical Illness in Children",[46,47,48,49,50,51,52,53],"Pediatric Intensive Care Unit","PICU","Arterial Blood Gas","Acidemia","Base Deficit","Serum Bicarbonate","Pediatric Critical Care","Mortality","NOT_YET_RECRUITING","2026-08-31",{"date":57,"type":58},"2026-09-03","ACTUAL",{"date":60,"type":38},"2026-10",{"date":62,"type":38},"2027-11",{"name":5,"class":6}]