[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648398":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":19,"responsibleParty":45,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":10,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Post-Implementation Cohort",null,"All patients with RAI greater than or equal to 8 (RAI+) and NGAL greater than or equal to 150 ng\u002FmL (NGAL+) in the two years after the clinical decision support tool is implemented. These patients will be compared to the cohort of patients with RAI greater than or equal to 8 and NGAL greater than or equal to 150 ng\u002FmL in the two years before the clinical decision support (CDS) tool is implemented.",[13],"Other: Furosemide Stress Test Clinical Decision Support Tool",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Furosemide Stress Test Clinical Decision Support Tool","The CDS strategy will be developed with key stakeholders in the Cincinnati Children's PICU, leveraging existing infrastructure and workflows. This CDS intervention will then be implemented as part of routine care in the PICU.",[9],[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Cincinnati Children's Hospital Medical Center","RECRUITING","Cincinnati","Ohio","45229","United States","US",{"type":29,"coordinates":30},"Point",[31,32],-84.51439,39.12711,{"lat":32,"lon":31},[35,40,42],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Natalja L Stanski, MD, MS","CONTACT","513-636-4334","natalja.stanski@cchmc.org",{"name":36,"role":41,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":43,"role":44,"phone":10,"phoneExt":10,"email":10},"Imogen Clover-Brown, MD","SUB_INVESTIGATOR",{"type":41,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Natalja Stanski","Co-Director, Center for Acute Care Nephrology; Attending Physician, Pediatric Intensive Care Unit (PICU); Associate Professor, UC Department of Pediatrics","100648398","fst-analysis-supporting-timely-therapy-and-risk-assessment-via-clinical-decision-support-for-kids-100648398",false,"NCT07718464","FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids","Furosemide Stress Test Implementation and Outcomes in Critically Ill Children at High Risk for Acute Kidney Injury: A Hybrid Study","FAST TRACK","Inclusion Criteria:\n\n* Admitted to the pediatric intensive care unit (PICU)\n* Renal Angina Index (RAI) greater than or equal to 8 (RAI+)\n* Urine NGAL greater than or equal to 150 ng\u002FmL (NGAL+)\n\nExclusion Criteria:\n\n* Receipt of renal replacement therapy prior to PICU admission","ALL",{"count":58,"type":59},120,"ESTIMATED","OBSERVATIONAL","The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney injury (AKI). The main question it aims to answer is: Does implementing the decision support tool reduce fluid overload and help predict which children will receive dialysis?\n\nResearchers will identify children admitted to the pediatric intensive care unit who are at high risk for AKI using risk stratification and biomarker testing, then compare outcomes in the two years after the tool is introduced with the two years before.",[63,64,65],"Acute Kidney Injury","Renal Replacement Therapy","Pediatric Intensive Care Unit",[67,68,69],"NGAL","Renal Angina Index","Furosemide Stress Test","2026-07-17",{"date":72,"type":73},"2026-07-22","ACTUAL",{"date":75,"type":73},"2026-05-27",{"date":77,"type":59},"2028-06",{"name":5,"class":6},1]