[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648950":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":373,"collaborators":24,"id":377,"slug":378,"hasResults":379,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":24,"eligibilityCriteria":383,"healthyVolunteers":379,"sex":384,"minAge":385,"maxAge":24,"enrollmentInfo":386,"targetDuration":24,"studyType":389,"phases":390,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":38,"whyStopped":24,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":410},{"fullName":5,"class":6},"Southeast University, China","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Pre-Implementation Usual Care","Participants in this arm are patients with moderate-to-severe ARDS who received ECMO before implementation of the standardized full-course ECMO management pathway. Clinical care will be provided according to usual practice at each participating center, including ECMO initiation, maintenance, complication management, weaning, and rehabilitation based on local protocols and clinician judgment.",[12],"Other: Usual Care",{"label":14,"type":15,"description":16,"interventionNames":17},"Post-Implementation ECMO Management Pathway","EXPERIMENTAL","Participants in this arm are patients with moderate-to-severe ARDS who receive ECMO after implementation of the standardized full-course ECMO management pathway. Clinical care will follow the pathway covering assessment of ECMO indications, ECMO initiation, maintenance management, complication prevention and management, weaning assessment, rehabilitation, and follow-up. Individualized adjustments are allowed according to patient condition, and pathway deviations will be recorded.",[18],"Other: Full-Course ECMO Management Pathway",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Full-Course ECMO Management Pathway","The intervention is a standardized full-course ECMO management pathway for patients with moderate-to-severe ARDS. The pathway covers assessment of ECMO indications, ECMO initiation, cannulation and anticoagulation strategies, mechanical ventilation management, hemodynamic and fluid management, infection prevention, analgesia and sedation, nutrition and rehabilitation, complication prevention and management, weaning assessment, discharge, and follow-up. Individualized adjustments are allowed according to patient condition, and pathway deviations will be recorded for quality improvement and subsequent analysis.",[14],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Usual Care","Usual care refers to ECMO management provided before implementation of the standardized full-course ECMO management pathway. Clinical decisions are made according to local practice and clinician judgment at each participating center.",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"yingzi Huang, M.D.","CONTACT","18271428804","yz_huang@126.com",[36,51,60,68,76,84,95,106,114,122,130,138,146,157,165,173,181,192,200,208,218,226,231,236,244,252,260,268,279,287,295,306,317,325,333,341,349,360,365],{"facility":37,"status":38,"city":39,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Beijing Anzhen Hospital, Capital Medical University","RECRUITING","Beijing","China","CN",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":24,"phoneExt":24,"email":24},"Zhongtao Du",{"facility":52,"status":53,"city":54,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":55,"geoPoint":59,"contacts":24},"The Second Hospital of Jilin University","NOT_YET_RECRUITING","Changchun",{"type":43,"coordinates":56},[57,58],125.32278,43.88,{"lat":58,"lon":57},{"facility":61,"status":53,"city":62,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":63,"geoPoint":67,"contacts":24},"West China Tianfu Hospital, Sichuan University","Chengdu",{"type":43,"coordinates":64},[65,66],104.06667,30.66667,{"lat":66,"lon":65},{"facility":69,"status":53,"city":70,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":71,"geoPoint":75,"contacts":24},"The First People's Hospital of Chenzhou","Chenzhou",{"type":43,"coordinates":72},[73,74],113.03333,25.8,{"lat":74,"lon":73},{"facility":77,"status":38,"city":78,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":79,"geoPoint":83,"contacts":24},"The Second Affiliated Hospital of Dalian Medical University","Dalian",{"type":43,"coordinates":80},[81,82],121.60222,38.91222,{"lat":82,"lon":81},{"facility":85,"status":38,"city":86,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Fuzhou University Affiliated Provincial Hospital","Fuzhou",{"type":43,"coordinates":88},[89,90],119.30611,26.06139,{"lat":90,"lon":89},[93],{"name":94,"role":32,"phone":24,"phoneExt":24,"email":24},"Shang",{"facility":96,"status":38,"city":97,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"The First Affiliated Hospital of Guangzhou Medical University","Guangzhou",{"type":43,"coordinates":99},[100,101],113.25,23.11667,{"lat":101,"lon":100},[104],{"name":105,"role":32,"phone":24,"phoneExt":24,"email":24},"Yan Wang",{"facility":107,"status":53,"city":108,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":109,"geoPoint":113,"contacts":24},"Affiliated Hangzhou First People's Hospital of Westlake University School of Medicine","Hangzhou",{"type":43,"coordinates":110},[111,112],120.16142,30.29365,{"lat":112,"lon":111},{"facility":115,"status":38,"city":108,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":116,"geoPoint":118,"contacts":119},"The Second Affiliated Hospital of Zhejiang University School of Medicine",{"type":43,"coordinates":117},[111,112],{"lat":112,"lon":111},[120],{"name":121,"role":32,"phone":24,"phoneExt":24,"email":24},"Xie",{"facility":123,"status":53,"city":124,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":125,"geoPoint":129,"contacts":24},"The First Affiliated Hospital of Harbin Medical University","Ha’erbin",{"type":43,"coordinates":126},[127,128],101.742,31.8696,{"lat":128,"lon":127},{"facility":131,"status":38,"city":124,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":132,"geoPoint":134,"contacts":135},"The Second Affiliated Hospital of Harbin Medical University",{"type":43,"coordinates":133},[127,128],{"lat":128,"lon":127},[136],{"name":137,"role":32,"phone":24,"phoneExt":24,"email":24},"Hongliang Wang",{"facility":139,"status":53,"city":140,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":141,"geoPoint":145,"contacts":24},"Huai'an First People's Hospital","Huai'an",{"type":43,"coordinates":142},[143,144],119.01917,33.58861,{"lat":144,"lon":143},{"facility":147,"status":38,"city":148,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Qilu Hospital of Shandong University","Jinan",{"type":43,"coordinates":150},[151,152],116.99722,36.66833,{"lat":152,"lon":151},[155],{"name":156,"role":32,"phone":24,"phoneExt":24,"email":24},"Hao Wang",{"facility":158,"status":53,"city":159,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":160,"geoPoint":164,"contacts":24},"The First People's Hospital of Kunshan","Kunshan",{"type":43,"coordinates":161},[162,163],120.95431,31.37762,{"lat":163,"lon":162},{"facility":166,"status":53,"city":167,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":168,"geoPoint":172,"contacts":24},"The First Hospital of Lanzhou University","Lanzhou",{"type":43,"coordinates":169},[170,171],103.83987,36.05701,{"lat":171,"lon":170},{"facility":174,"status":53,"city":175,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":176,"geoPoint":180,"contacts":24},"The First People's Hospital of Lianyungang","Lianyungang",{"type":43,"coordinates":177},[178,179],119.21556,34.59845,{"lat":179,"lon":178},{"facility":182,"status":38,"city":183,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Liuzhou People's Hospital","Liuzhou",{"type":43,"coordinates":185},[186,187],109.40698,24.32405,{"lat":187,"lon":186},[190],{"name":191,"role":32,"phone":24,"phoneExt":24,"email":24},"Wenfang Jiang",{"facility":193,"status":53,"city":194,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":195,"geoPoint":199,"contacts":24},"Jiangsu Province Hospital","Nanjing",{"type":43,"coordinates":196},[197,198],118.77778,32.06167,{"lat":198,"lon":197},{"facility":201,"status":38,"city":194,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":202,"geoPoint":204,"contacts":205},"Nanjing Drum Tower Hospital (The Affiliated Hospital of Nanjing University Medical School)",{"type":43,"coordinates":203},[197,198],{"lat":198,"lon":197},[206],{"name":207,"role":32,"phone":24,"phoneExt":24,"email":24},"Danjiang Dong",{"facility":209,"status":38,"city":194,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":210,"geoPoint":212,"contacts":213},"Zhongda Hospital Southeast University",{"type":43,"coordinates":211},[197,198],{"lat":198,"lon":197},[214],{"name":215,"role":32,"phone":216,"phoneExt":24,"email":217},"Xiaojing Wu","13951876234","36410257@qq.com",{"facility":219,"status":53,"city":220,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":221,"geoPoint":225,"contacts":24},"The First Affiliated Hospital of Guangxi Medical University","Nanning",{"type":43,"coordinates":222},[223,224],108.31667,22.81667,{"lat":224,"lon":223},{"facility":227,"status":53,"city":220,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":228,"geoPoint":230,"contacts":24},"The People's Hospital of Guangxi Zhuang Autonomous Region",{"type":43,"coordinates":229},[223,224],{"lat":224,"lon":223},{"facility":232,"status":53,"city":220,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":233,"geoPoint":235,"contacts":24},"The Second Affiliated Hospital of Guangxi Medical University",{"type":43,"coordinates":234},[223,224],{"lat":224,"lon":223},{"facility":237,"status":53,"city":238,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":239,"geoPoint":243,"contacts":24},"Affiliated Hospital of Nantong University","Nantong",{"type":43,"coordinates":240},[241,242],120.87472,32.03028,{"lat":242,"lon":241},{"facility":245,"status":53,"city":246,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":247,"geoPoint":251,"contacts":24},"General Hospital of Ningxia Medical University","Ningxiang",{"type":43,"coordinates":248},[249,250],111.20523,37.34,{"lat":250,"lon":249},{"facility":253,"status":53,"city":254,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":255,"geoPoint":259,"contacts":24},"The Affiliated Hospital of Qinghai University","Qinghai",{"type":43,"coordinates":256},[257,258],106.075,25.80833,{"lat":258,"lon":257},{"facility":261,"status":38,"city":262,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":263,"geoPoint":267,"contacts":24},"Quzhou People's Hospital","Quzhou",{"type":43,"coordinates":264},[265,266],118.86861,28.95944,{"lat":266,"lon":265},{"facility":269,"status":38,"city":270,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (SAMS&SPPH, Affiliated Hospital of UESTC)","Sichuan",{"type":43,"coordinates":272},[273,274],105.48032,35.1221,{"lat":274,"lon":273},[277],{"name":278,"role":32,"phone":24,"phoneExt":24,"email":24},"Hongli He",{"facility":280,"status":53,"city":281,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":282,"geoPoint":286,"contacts":24},"Suining Central Hospital","Suining",{"type":43,"coordinates":283},[284,285],105.57332,30.50802,{"lat":285,"lon":284},{"facility":288,"status":53,"city":289,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":290,"geoPoint":294,"contacts":24},"The First Affiliated Hospital of Soochow University","Suzhou",{"type":43,"coordinates":291},[292,293],120.59538,31.30408,{"lat":293,"lon":292},{"facility":296,"status":38,"city":297,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"Wuxi People's Hospital","Wuxi",{"type":43,"coordinates":299},[300,301],120.28857,31.56887,{"lat":301,"lon":300},[304],{"name":305,"role":32,"phone":24,"phoneExt":24,"email":24},"Hongyang Xu",{"facility":307,"status":38,"city":308,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"The Second Affiliated Hospital of Xi'an Jiaotong University","Xi'an",{"type":43,"coordinates":310},[311,312],108.92861,34.25833,{"lat":312,"lon":311},[315],{"name":316,"role":32,"phone":24,"phoneExt":24,"email":24},"jing Geng",{"facility":318,"status":53,"city":319,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":320,"geoPoint":324,"contacts":24},"The First Affiliated Hospital of Xiamen University","Xiamen",{"type":43,"coordinates":321},[322,323],118.08187,24.47979,{"lat":323,"lon":322},{"facility":326,"status":53,"city":327,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":328,"geoPoint":332,"contacts":24},"Xinyang Central Hospital","Xinyang",{"type":43,"coordinates":329},[330,331],114.06556,32.12278,{"lat":331,"lon":330},{"facility":334,"status":53,"city":335,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":336,"geoPoint":340,"contacts":24},"The Affiliated Hospital of Xuzhou Medical Universit","Xuzhou",{"type":43,"coordinates":337},[338,339],117.28386,34.20442,{"lat":339,"lon":338},{"facility":342,"status":53,"city":343,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":344,"geoPoint":348,"contacts":24},"Northern Jiangsu People's Hospital","Yangzhou",{"type":43,"coordinates":345},[346,347],119.43583,32.39722,{"lat":347,"lon":346},{"facility":350,"status":38,"city":351,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"Henan Provincial People's Hospital","Zhengzhou",{"type":43,"coordinates":353},[354,355],113.64861,34.75778,{"lat":355,"lon":354},[358],{"name":359,"role":32,"phone":24,"phoneExt":24,"email":24},"Huanzhang Shao",{"facility":361,"status":53,"city":351,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":362,"geoPoint":364,"contacts":24},"The First Affiliated Hospital of Zhengzhou University",{"type":43,"coordinates":363},[354,355],{"lat":355,"lon":354},{"facility":366,"status":53,"city":367,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":368,"geoPoint":372,"contacts":24},"Zhongshan Hospital of Traditional Chinese Medicine","Zhongshan",{"type":43,"coordinates":369},[370,371],113.37912,22.52306,{"lat":371,"lon":370},{"type":374,"investigatorFullName":375,"investigatorTitle":376,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Jianfeng Xie","Professor, Director of ICU","100648950","full-course-ecmo-strategy-for-moderate-to-severe-ards-100648950",false,"NCT07726953","Full-Course ECMO Strategy for Moderate-to-Severe ARDS","Establishment and Evaluation of a Full-Course ECMO Management Strategy for Patients With Moderate-to-Severe ARDS","Inclusion Criteria:\n\n* 1\\. Age 18 years or older. 2. Diagnosed with moderate-to-severe acute respiratory distress syndrome according to the global definition of ARDS.\n\nExclusion Criteria:\n\n\\- 1. Patients with tracheostomy before screening. 2. Patients who have received lung transplantation or are receiving venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation.\n\n3\\. Patients with cardiogenic shock requiring venoarterial ECMO or venoarterial-venous ECMO support.","ALL","18 Years",{"count":387,"type":388},500,"ESTIMATED","INTERVENTIONAL",[391],"NA","China faces major challenges in the ECMO management of patients with moderate-to-severe ARDS, including substantial heterogeneity in clinical practice, low weaning success rates, and high complication rates. A key underlying reason is the lack of a standardized full-course management pathway that is applicable to real-world clinical practice in China. This study focuses on the construction and evidence-based evaluation of a precision full-course ECMO management pathway for patients with moderate-to-severe ARDS, aiming to address fragmented care processes and delayed quality improvement.\n\nThe study includes three main components. First, multidisciplinary consensus and evidence-based findings will be integrated to develop a standardized management pathway covering the full chain of assessment, initiation, maintenance, weaning, and rehabilitation. Second, a nationwide multicenter real-world study with a before-and-after design will be conducted to systematically evaluate the clinical effectiveness of this pathway in reducing mortality and complications and improving patient outcomes. Third, a closed-loop dynamic optimization system based on \"pathway-data-feedback-improvement\" will be established. With the support of an intelligent data platform and multidisciplinary review mechanisms, the pathway will be continuously updated and refined.\n\nThrough this study, a reproducible, traceable, and evaluable full-course ECMO management strategy is expected to be established. The study will also build a national collaborative research network and support the development of living clinical guidance, promoting the transition of ECMO care in China from experience-based practice toward standardized, homogeneous, and intelligent management, and providing a key technical framework and practical model for improving critical care.",[394],"Acute Respiratory Distress Syndrome",[394,396,397,398,399,400],"Moderate-to-Severe ARDS","Extracorporeal Membrane Oxygenation","ECMO","VV-ECMO","ECMO Management Pathway","2026-07-21",{"date":403,"type":404},"2026-07-27","ACTUAL",{"date":406,"type":404},"2026-06-16",{"date":408,"type":388},"2030-02-28",{"name":5,"class":6},39]