[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645728":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":25,"responsibleParty":41,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"St. Jude Children's Research Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"UCD group",null,"Participants with urea cycle disorders (UCD) who meet the Eligibility Criteria and consent to participate",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","Healthy controls who meet the Eligibility Criteria and consent to participate",[16],{"name":17,"affiliation":5,"role":18},"Andrea Gropman, M.D.","PRINCIPAL_INVESTIGATOR",[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Jean Laboe, RN","CONTACT","901-595-1693","jean.laboe@stjude.org",[26],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Memphis","Tennessee","38105","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-90.04898,35.14953,{"lat":37,"lon":36},[40],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100645728","functional-evaluation-in-patients-with-urea-cycle-disorders-ucd-during-a-driving-task-100645728",false,"NCT07701694","Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task","Cognitive and Motor Function Examination in Patients With Urea Cycle Disorders (UCD) During a Driving Task Using Functional Near Infrared Spectroscopy (fNIRS)","Inclusion Criteria:\n\n* Individuals 16 to 40 years with molecular or biochemical confirmation of a urea cycle disorder.\n* Healthy individuals will serve as an age and sex matched comparison group. Active driver's license for at least 6 months\n* Read and understand English. as the tasks have not been validated in other languages\n* IQ \\>=70.\n\nExclusion Criteria:\n\n* Skin disease that affects the scalp\n* Past or present vascular disease\n* Head trauma with loss of consciousness in the last year or evidence of cognitive impairment due to and persisting after head trauma\n* Motor movement disorder which may cause excessive movement or impede use of the steering wheel and\u002For pedal\n* Premature birth or birth before 32 weeks of gestation\n* The participant is taking a stimulant or antidepressant\n* Allergy to any component of the device, although expected to be rare\n* History of psychosis\n* Self-reported motion or cyber sickness\n* Self-reported illicit substance use\n* Vision disorder",true,"ALL","16 Years","40 Years",{"count":55,"type":56},60,"ESTIMATED","OBSERVATIONAL","This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and attention.",[60],"Urea Cycle Disorder",[62,63,64,65,66],"Participants with Urea Cycle Disorder","Healthy Volunteers","Cognitive function examination","Motor function examination","Simulated driving task with functional near-infrared spectroscopy monitoring","2026-07-29",{"date":69,"type":70},"2026-07-31","ACTUAL",{"date":72,"type":70},"2026-07-20",{"date":74,"type":56},"2032-08",{"name":5,"class":6},1]