[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656260":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":29,"overallOfficials":39,"centralContacts":46,"locations":29,"responsibleParty":52,"collaborators":29,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":29,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":29,"enrollmentInfo":65,"targetDuration":68,"studyType":69,"phases":29,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":81,"whyStopped":29,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":29},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Incidence of clinically important ICU-acquired gastrointestinal bleeding","Proportion of critically ill patients who develop clinically important gastrointestinal bleeding (overt bleeding with hemodynamic compromise or significant hemoglobin drop, or occult bleeding confirmed by fecal occult blood test or endoscopy) occurring 24 hours or more after ICU admission.","Up to 30 days",[14,17,20,23,26],{"measure":15,"description":16,"timeFrame":12},"Independent risk factors for gastrointestinal bleeding","Odds ratios of clinical, laboratory, and treatment-related factors for the occurrence of clinically important gastrointestinal bleeding using multivariable logistic regression analysis.",{"measure":18,"description":19,"timeFrame":12},"ICU length of stay","Duration of intensive care unit stay in days.",{"measure":21,"description":22,"timeFrame":12},"Blood transfusion requirement","Number of units of packed red blood cells transfused during the ICU stay.",{"measure":24,"description":25,"timeFrame":12},"ICU mortality","Proportion of patients who die during the ICU stay.",{"measure":27,"description":28,"timeFrame":12},"Need for endoscopic or surgical intervention","Proportion of patients requiring endoscopic therapy or surgical intervention for gastrointestinal bleeding.",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"COHORT","PROSPECTIVE","Gastrointestinal bleeding is a serious complication in critically ill patients and is associated with increased morbidity and mortality. This prospective observational cohort study will include adult patients (≥18 years) admitted to the intensive care units of Assiut University Hospitals.\n\nPatients will be followed during their ICU stay for the occurrence of clinically important gastrointestinal bleeding (overt or occult) occurring ≥24 hours after admission. Clinical, laboratory, and treatment-related data will be collected to identify independent risk factors and to assess associated clinical outcomes.","Adult patients (≥18 years) admitted to the intensive care units of Assiut University Hospitals.",[36],{"label":37,"type":29,"description":38,"interventionNames":29},"Single cohort: Critically ill adult patients admitted to ICU","Adult patients admitted to the intensive care units who will be followed for the occurrence of ICU-acquired gastrointestinal bleeding and its associated risk factors and outcomes.",[40,44],{"name":41,"affiliation":42,"role":43},"Ahmed M Ashmawy, prof","Internal Medicine Department, Assiut University Hospitals","STUDY_CHAIR",{"name":45,"affiliation":42,"role":43},"AbdelHamid M Aly, Prof",[47],{"name":48,"role":49,"phone":50,"phoneExt":29,"email":51},"Haidy M Mohamed, Resident","CONTACT","0 11 50184210","Heidi.18313235@med.aun.edu.eg",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Haidy Mohamed Mahmoud","Resident Physician","100656260","gastrointestinal-bleeding-in-critically-ill-patients-100656260",false,"NCT07822958","Gastrointestinal Bleeding in Critically Ill Patients","Gastrointestinal Bleeding in Critically Ill Patients: Prevalence, Risk Factors, and Clinical Outcomes","Inclusion Criteria:\n\n* \\- Age 18 years or older\n* Admission to the intensive care unit\n* Onset of gastrointestinal bleeding after ≥24 hours of ICU admission (to distinguish ICU-acquired bleeding)\n* Overt gastrointestinal bleeding (hematemesis, melena, hematochezia, or bloody nasogastric aspirate) and\u002For occult bleeding confirmed by fecal occult blood test or endoscopy\n* Written informed consent (from patient or legal representative)\n\nExclusion Criteria:\n\n* \\- Age less than 18 years\n* Pregnancy\n* Gastrointestinal bleeding clearly due to trauma or recent gastrointestinal surgery\u002Fprocedure\n* Known bleeding disorder unrelated to critical illness\n* Recent receipt of peptic ulcer prophylaxis (two or more doses)\n* Incomplete medical records or loss to follow-up\n* Refusal to participate","ALL","18 Years",{"count":66,"type":67},310,"ESTIMATED","28 Days","OBSERVATIONAL","This prospective cohort study aims to determine the prevalence of gastrointestinal bleeding among critically ill patients admitted to intensive care units, identify independent risk factors, and describe clinical outcomes including ICU length of stay, transfusion requirements, and mortality at Assiut University Hospitals.",[72,73],"Gastrointestinal Hemorrhage","Critical Illness",[75,76,77,78,79,80],"Mortality","Gastrointestinal bleeding","Critically ill","ICU","Risk factors","Assiut","NOT_YET_RECRUITING","2026-09-10",{"date":84,"type":85},"2026-09-16","ACTUAL",{"date":87,"type":67},"2026-09-05",{"date":89,"type":67},"2028-06-01",{"name":5,"class":6}]