[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653377":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":34,"studyPopulation":26,"armGroups":35,"interventions":46,"overallOfficials":26,"centralContacts":26,"locations":52,"responsibleParty":75,"collaborators":26,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":26,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":55,"whyStopped":26,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Shifa Tameer-e-Millat University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":22,"otherOutcomes":26},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Change in Pain Intensity Measured by the Visual Analog Scale (VAS), 0-10; lower scores indicate less pain","To compare the effect of Sensory-Modulated Graded Weight-Bearing Physiotherapy on pain intensity between male and female patients with knee osteoarthritis","Baseline, Week 3, and Week 6",{"measure":14,"description":15,"timeFrame":12},"Change in Physical Function Measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale, 0-68; lower scores indicate better function","To compare the effect of Sensory-Modulated Graded Weight-Bearing Physiotherapy on physical function between male and female patients with knee osteoarthritis",{"measure":17,"description":18,"timeFrame":12},"Change in Knee Joint Proprioception Measured by the Joint Position Sense (JPS) Test (absolute repositioning error in degrees; lower values indicate better proprioception)","To compare the effect of Sensory-Modulated Graded Weight-Bearing Physiotherapy on proprioception between male and female patients with knee osteoarthritis",{"measure":20,"description":21,"timeFrame":12},"Change in mobility Measured by the Six-Minute Walk Test (6MWT), distance walked in meters; higher values indicate better gait performance","To compare the effect of Sensory-Modulated Graded Weight-Bearing Physiotherapy on mobility between male and female patients with knee osteoarthritis",[23],{"measure":24,"description":25,"timeFrame":12},"Change in Health-Related Quality of Life Measured by the 36-Item Short Form Health Survey (SF-36), 0-100; higher scores indicate better health-related quality of life","To compare the effect of Sensory-Modulated Graded Weight-Bearing Physiotherapy on health-related quality of life between male and female patients with knee osteoarthritis",null,{"allocation":28,"interventionModel":29,"interventionModelDescription":30,"primaryPurpose":31,"observationalModel":26,"timePerspective":26,"maskingInfo":32},"NON_RANDOMIZED","PARALLEL","This study will evaluate the effect of Sensory Modulated Graded Weight Bearing Physiotherapy and compare the treatment response between male and female participants. The study will include two parallel groups: a male group and a female group. Both groups will receive the same physiotherapy intervention for 6 weeks. Outcomes will be assessed before and after the intervention to determine whether the effectiveness of the intervention differs between male and female participants.","TREATMENT",{"masking":33,"maskingDescription":26,"whoMasked":26},"NONE","Knee osteoarthritis (KOA) is a common degenerative joint disorder associated with pain, impaired physical function, reduced proprioception, decreased mobility, and poor quality of life. Physiotherapy plays a central role in the conservative management of KOA by reducing pain and improving functional performance. Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) integrates sensory stimulation with progressive weight-bearing exercises to enhance neuromuscular control, balance, proprioception, and functional recovery.\n\nThis comparative experimental study aims to evaluate the effectiveness of SMGWBP in individuals with Kellgren-Lawrence grade II or III knee osteoarthritis and to compare treatment outcomes between male and female participants. A total of 52 participants will be recruited through purposive sampling. All participants will receive a standardized 6-week physiotherapy program consisting of three supervised sessions per week.\n\nOutcome assessments will be performed at three time points: baseline (pre-intervention), mid-intervention (3 weeks), and post-intervention (6 weeks). The primary and secondary outcome measures include pain intensity measured using the Visual Analog Scale (VAS), physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), proprioception using the Joint Position Sense (JPS) test, gait performance using the Six-Minute Walk Test (6MWT), health-related quality of life using the Short Form-36 (SF-36), and treatment compliance. The study will examine changes in these outcomes over time and compare the effectiveness of the intervention between male and female participants.",[36,42],{"label":37,"type":38,"description":39,"interventionNames":40},"Arm 1 - Arm Title: Male Participants","EXPERIMENTAL","Twenty-six male participants with knee osteoarthritis will receive the Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme for six weeks, with three supervised sessions per week. Outcomes will be assessed at baseline, Week 3, and Week 6.",[41],"Behavioral: Sensory-Modulated Graded Weight-Bearing Physiotherapy",{"label":43,"type":38,"description":44,"interventionNames":45},"Arm 2 - Arm Title: Female Participants","Twenty-six female participants with knee osteoarthritis will receive the Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme for six weeks, with three supervised sessions per week. Outcomes will be assessed at baseline, Week 3, and Week 6.",[41],[47],{"type":48,"name":49,"description":50,"armGroupLabels":51,"otherNames":26},"BEHAVIORAL","Sensory-Modulated Graded Weight-Bearing Physiotherapy","A structured six-week Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme consisting of three supervised sessions per week (18 sessions total). Each session includes warm-up, sensory modulation, proprioceptive training, graded weight-bearing strengthening, functional mobility exercises, and cool-down activities. The programme progresses through three phases: Weeks 1-2 focus on sensory activation and proprioceptive training; Weeks 3-4 on graded weight-bearing strengthening; and Weeks 5-6 on functional weight-bearing integration. Exercises are progressed according to participant tolerance, pain severity, and functional performance. Both male and female groups receive the same intervention.",[37,43],[53],{"facility":54,"status":55,"city":56,"state":57,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"T.H.Q hospital","RECRUITING","Gujar Khan","Punjab Province","Pakistan","PK",{"type":61,"coordinates":62},"Point",[63,64],73.30433,33.25411,{"lat":64,"lon":63},[67,72],{"name":68,"role":69,"phone":70,"phoneExt":26,"email":71},"Dr.Sarmaad Kayyani, MBBS","CONTACT","+923005088112","Sarmaadkayyani@gmail.com",{"name":73,"role":74,"phone":26,"phoneExt":26,"email":26},"Sadia Akhtar, DPT","PRINCIPAL_INVESTIGATOR",{"type":74,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Fouzia Batool","Assistant Professor","100653377","gender-based-comparison-of-the-effects-of-sensory-modulated-graded-weight-bearing-physiotherapy-in-adults-with-knee-osteoarthritis-100653377",false,"NCT07784998","Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis","GSMGWBP","Inclusion criteria\n\n* Participants are eligible for inclusion if they meet the following criteria:\n* Age between 40 and 60 years.\n* Diagnosed with Grade II or Grade III Knee Osteoarthritis according to Kellgren-Lawrence Classification.\n* Ability to ambulate independently without assistive devices.\n* Mild to moderate pain intensity with a Visual Analogue Scale score less than seven.\n* Ability to understand and follow instructions.\n* Willingness to participate and provide written informed consent. Exclusion Criteria\n* Participants are excluded if they meet any of the following criteria:\n* History of knee surgery within the previous six months.\n* Neurological disorders affecting balance, gait, or proprioception.\n* Severe cardiovascular disease limiting participation in exercise.\n* Rheumatoid arthritis or other inflammatory arthritic conditions.\n* Severe cognitive impairment.\n* Any medical condition that contraindicates participation in rehabilitation exercises.","ALL","40 Years","60 Years",{"count":89,"type":90},52,"ESTIMATED","INTERVENTIONAL",[93],"NA","This comparative experimental study aims to evaluate the effectiveness of Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) in patients with knee osteoarthritis and compare treatment outcomes between male and female participants. Participants will receive a 6-week physiotherapy program with assessments conducted at baseline (pre-intervention), mid-intervention (3 weeks), and post-intervention (6 weeks) using validated outcome measures.",[96],"Knee Osteoarthristis",[98,49,99,100,101,102,103,104,105,106],"Knee Osteoarthritis","Physiotherapy","Rehabilitation","Pain","WOMAC","Proprioception","Six-Minute Walk Test","SF-36","Gender Differences","2026-09-12",{"date":109,"type":110},"2026-09-16","ACTUAL",{"date":112,"type":110},"2026-07-13",{"date":114,"type":90},"2026-09-23",{"name":5,"class":6},1]