[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649280":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":19,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":19,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":19,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":28,"whyStopped":19,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Institute of Oncology Ljubljana","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Comprehensive Breast Cancer Risk Assessment","EXPERIMENTAL","Participants undergo a comprehensive reassessment of individual breast cancer risk. The assessment includes specialist-assisted review of personal risk factors, verification of family cancer history, risk calculation using the S-IBIS and CanRisk models, genetic counseling, and genetic testing when clinically indicated. Participants receive risk-adapted recommendations for further breast cancer screening and follow-up.",[13],"Other: Comprehensive Clinical and Genetic Breast Cancer Risk Assessment",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Comprehensive Clinical and Genetic Breast Cancer Risk Assessment","Participants receive an individual clinical and genetic breast cancer risk assessment. Personal risk factors are reviewed with the assistance of a specialist, and family cancer history is verified using the Slovenian Cancer Registry. Breast cancer risk is calculated using the S-IBIS and CanRisk models. Genetic counseling is provided, and genetic testing is performed when the participant meets the applicable clinical criteria. Recommendations for screening and follow-up are adapted to the reassessed level of breast cancer risk.",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Clinical Cancer Genetics Clinic","CONTACT","+386 1 587 9649","genetika@onko-i.si",[27],{"facility":5,"status":28,"city":29,"state":19,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Ljubljana","1000","Slovenia","SI",{"type":34,"coordinates":35},"Point",[36,37],14.50513,46.05108,{"lat":37,"lon":36},[40],{"name":41,"role":23,"phone":42,"phoneExt":19,"email":43},"Katja Jarm, MD, PhD","+38615879573","kjarm@onko-i.si",{"type":45,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100649280","genetic-assessment-of-breast-cancer-risk-in-women-in-the-dora-programme-100649280",false,"NCT07734389","Genetic Assessment of Breast Cancer Risk in Women in the DORA Programme","Impact of Genetic Assessment on the Evaluation of Individual Breast Cancer Risk Among Women at Increased Risk in the DORA Programme","Inclusion Criteria:\n\n\\- Women who participated in the previous DORA study and were classified by the S-IBIS model as having moderately increased or high breast cancer risk.\n\nExclusion Criteria:\n\n* Diagnosis of breast cancer.","FEMALE","53 Years","54 Years",{"count":57,"type":58},291,"ESTIMATED","INTERVENTIONAL",[61],"NA","This prospective study evaluates whether a more detailed clinical and genetic assessment can improve the classification of individual breast cancer risk among women previously identified as having moderately increased or high breast cancer risk in the Slovenian DORA breast cancer screening programme.\n\nWomen who agree to participate complete questionnaires and attend an individual genetic counseling appointment at the Institute of Oncology Ljubljana. Personal breast cancer risk factors are reviewed with the assistance of a specialist, and reported family cancer history is verified using data from the Slovenian Cancer Registry. Breast cancer risk is reassessed using the S-IBIS and CanRisk models. Genetic testing is offered to participants who meet the applicable clinical criteria.\n\nThe study will evaluate changes in breast cancer risk classification, compare risk estimates obtained using the S-IBIS and CanRisk models, and provide participants with individualized recommendations for breast cancer screening and follow-up according to their reassessed risk.",[64,65],"Breast Cancer","Breast Cancer Risk",[67,68,69,70,71,72],"Breast Cancer Risk Assessment","Breast Cancer Screening","Genetic Counseling","Genetic Testing","Risk-Adapted Screening","Family History of Cancer","2026-07-27",{"date":75,"type":76},"2026-07-29","ACTUAL",{"date":78,"type":76},"2025-03-10",{"date":80,"type":58},"2027-12-31",{"name":5,"class":6},1]