[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652826":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":49,"collaborators":52,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":19,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":19,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"The University of Texas Health Science Center at San Antonio","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Insulin stimulated","EXPERIMENTAL","80mU\u002Fm2\\*min euglycemic\u002Fhyperinsulinemic clamp",[13],"Other: Insulin 80mU\u002Fm2*min",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Insulin 80mU\u002Fm2*min","80mU\u002Fm2\\*min euglycemic-hyperinsulinemic clamp",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Luke Norton, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Luke Norton, Ph.D","CONTACT","210-567-0739","nortonl@uthscsa.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Texas Diabetes Institute - University Health System, San Antonio, Texas 78207","RECRUITING","San Antonio","Texas","78229","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-98.49363,29.42412,{"lat":43,"lon":42},[46,47,48],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},{"name":19,"role":27,"phone":19,"phoneExt":19,"email":29},{"name":26,"role":23,"phone":19,"phoneExt":19,"email":19},{"type":23,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Luke Norton","Associate Professor",[53],{"name":54,"class":55},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100652826","genetic-of-skeletal-muscle-insulin-resistance-100652826",false,"NCT07780513","Genetic of Skeletal Muscle Insulin Resistance","Identification of Cell Type-Specific Insulin Responsive Quantitative Trait Loci in Human Skeletal Muscle","Inclusion Criteria:\n\n* Males and Females Age 18-75\n* Body Mass Index (BMI) \\> 18\n* Normal glucose tolerance as defined by:\n\nFasting blood sugar \\\u003C 100 mg\u002FdL 2-hour Oral Glucose Tolerance Test (OGTT) \\\u003C 140mg\u002FdL Stable weight over the past 3 months defined as \\>±5% change in body weight\n\n* Hemoglobin A1c \\\u003C 5.7\n* Creatinine \\\u003C 2\n* Aspartate aminotransferase\u002FAlanine transaminase (AST\u002FALT) \\\u003C 75\n* Blood sodium 135 to 145 mEq\u002FL\n* Blood potassium 3.6 to 5.2 mmol\u002FL\\[MH1.1\\]\n\nExclusion Criteria:\n\n* Urine albumin excretion\\>300mg\u002Fday\n* Partial thromboplastin time (PTT) \\>35International normalized ratio (INR) \\> 1.2\n* No oral corticosteroids for 1 month\n* No Sodium-glucose co-transporter 2 (SGLT2) inhibitor for 3 months\n* No glucagon-like peptide-1 (GLP-1) receptor agonist for 6 months\n* Any anti-platelet or anti-coagulation medication other than as needed for Pain Management\n* No alcohol 4 days before the insulin clamp and biopsy procedure\n* No acute structural knee injuries\n* No Rheumatologic muscular or nervous system disease\n* Pregnancy, Intentions to become pregnant, or Breastfeeding\n* Blood Pressure \\>170\u002F110\n* Temperature \\> 100F\n* Triglycerides \\> 400 by lipid panel\n* Hemoglobin \\\u003C10g\u002FdL\n* 1+ or greater Blood on Urinalysis\n* 2+ or greater Protein on Urinalysis\n* Electrocardiogram (EKG) abnormalities, including but not limited to ST elevations, T wave abnormalities, evidence of recent prior infarct",true,"ALL","18 Years","75 Years",{"count":68,"type":69},100,"ESTIMATED","INTERVENTIONAL",[72],"NA","In this study, we will use euglycemic\u002Fhyperinsulinemic clamps, longitudinal skeletal muscle biopsies, and single nucleus RNA- and ATAC- sequencing to reveal cell type-specific molecular response Quantitative trait loci (rQTLs) acutely regulated by insulin signaling and glucose uptake.",[75],"Insulin Stimulated",[77,78,79],"Insulin","Skeletal muscle","Quantitative trait loci (QTL)","2026-08-18",{"date":82,"type":83},"2026-08-21","ACTUAL",{"date":85,"type":69},"2026-08-31",{"date":87,"type":69},"2031-07-31",{"name":5,"class":6},1]