[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648518":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":158,"collaborators":162,"id":176,"slug":177,"hasResults":178,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":184,"sex":185,"minAge":186,"maxAge":187,"enrollmentInfo":188,"targetDuration":20,"studyType":191,"phases":192,"briefSummary":194,"conditions":195,"keywords":200,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":215},{"fullName":5,"class":6},"Technical University of Munich","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Resistance Training Group","EXPERIMENTAL","Participants in this single-arm cohort will undergo an 8-week standardized, hypertrophy-focused lower-body resistance training program.",[13],"Behavioral: Hypertrophy-focused Resistance Training",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Hypertrophy-focused Resistance Training","Standardized training consisting of twice-weekly supervised sessions for 8 weeks. Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions. Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Henning Wackerhage, Prof. Dr.","CONTACT","+49 89 289 24480","henning.wackerhage@tum.de",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Lara Becker","lara.becker@tum.de",[31,50,65,80,97,112,126,142],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"University of Jyväskylä, Faculty of Sport and Health Sciences","RECRUITING","Jyväskylä","Central Finland","40014","Finland","FI",{"type":40,"coordinates":41},"Point",[42,43],25.72088,62.24147,{"lat":43,"lon":42},[46],{"name":47,"role":24,"phone":48,"phoneExt":20,"email":49},"Juha Ahtiainen, Prof. Dr.","+358408053740","juha.ahtiainen@jyu.fi",{"facility":51,"status":33,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Technical University of Munich, TUM School of Medicine and Health","München","Bavaria","80809","Germany","DE",{"type":40,"coordinates":58},[59,60],13.46314,48.69668,{"lat":60,"lon":59},[63,64],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},{"facility":66,"status":33,"city":67,"state":68,"zip":69,"country":55,"countryCode":56,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"DLR Cologne, Department of Metabolism and Human Performance","Cologne","North Rhine-Westphalia","51147",{"type":40,"coordinates":71},[72,73],6.95,50.93333,{"lat":73,"lon":72},[76],{"name":77,"role":24,"phone":78,"phoneExt":20,"email":79},"Dominik Pesta, Prof. Dr.","+49 2203 601 2028","dominik.pesta@dlr.de",{"facility":81,"status":33,"city":82,"state":68,"zip":83,"country":55,"countryCode":56,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"iST University of Applied Sciences","Düsseldorf","40233",{"type":40,"coordinates":85},[86,87],6.77927,51.22319,{"lat":87,"lon":86},[90,94],{"name":91,"role":24,"phone":92,"phoneExt":20,"email":93},"Stephan Geisler, Prof.Dr.","+49 211 86668 6104","sgeisler@ist-hochschule.de",{"name":95,"role":24,"phone":20,"phoneExt":20,"email":96},"Tim Havers","thavers@ist-hochschule.de",{"facility":98,"status":33,"city":99,"state":100,"zip":101,"country":55,"countryCode":56,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"TU Chemnitz, Sports Medicine and Exercise Therapy","Chemnitz","Saxony","09126",{"type":40,"coordinates":103},[104,105],12.92922,50.8357,{"lat":105,"lon":104},[108],{"name":109,"role":24,"phone":110,"phoneExt":20,"email":111},"Nico Nitzsche, PD Dr. Dr.","+49 371 531-37326","nico.nitzsche@hsw.tu-chemnitz.de",{"facility":113,"status":33,"city":114,"state":100,"zip":115,"country":55,"countryCode":56,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Institute for Applied Training Science (IAT) Leipzig","Leipzig","04109",{"type":40,"coordinates":117},[118,119],12.37129,51.33962,{"lat":119,"lon":118},[122],{"name":123,"role":24,"phone":124,"phoneExt":20,"email":125},"Katharina Dunst, Dr.","+49 341 4945-184","AnnaKatharina.Dunst@sport-iat.de",{"facility":127,"status":33,"city":128,"state":128,"zip":129,"country":130,"countryCode":131,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"University of Limerick, Department of Physical Education and Sport Sciences (PESS)","Limerick","V94 T9PX","Ireland","IE",{"type":40,"coordinates":133},[134,135],-8.62306,52.66472,{"lat":135,"lon":134},[138],{"name":139,"role":24,"phone":140,"phoneExt":20,"email":141},"Brian Carson, Prof.","+353 (0)61 20 2896","Brian.Carson@ul.ie",{"facility":143,"status":33,"city":144,"state":144,"zip":145,"country":146,"countryCode":147,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Universidad Politécnica de Madrid, Facultad de Ciencias de la Actividad Física y del Deporte (INEF)","Madrid","28040","Spain","ES",{"type":40,"coordinates":149},[150,151],-3.70256,40.4165,{"lat":151,"lon":150},[154],{"name":155,"role":24,"phone":156,"phoneExt":20,"email":157},"Pedro José Benito, Prof. Dr.","+34 91 336 40 12","pedroj.benito@upm.es",{"type":159,"investigatorFullName":160,"investigatorTitle":161,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Prof. Dr. Henning Wackerhage","Professor",[163,165,167,169,171,174],{"name":164,"class":6},"Chemnitz University of Technology",{"name":166,"class":6},"DLR German Aerospace Center",{"name":168,"class":6},"University of Jyvaskyla",{"name":170,"class":6},"University of Limerick",{"name":172,"class":173},"IST University of Applied Sciences Düsseldorf","UNKNOWN",{"name":175,"class":173},"Institute for Applied Training Science (IAT\u002FFES e.V.)","100648518","glycolytic-phenotype-vlapeak-and-magnitude-of-skeletal-muscle-hypertrophy-after-resistance-training-100648518",false,"NCT07721766","Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training","HyperLa: Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training: A Multi-centre Study by the HyperLa Study Group","HyperLa","Inclusion Criteria:\n\n* Body Mass Index (BMI) between 20-29 kg\u002Fm2\n* No structured resistance training performed in the last twelve months.\n* Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.\n* No history of competitive strength or physique sports.\n\nExclusion Criteria:\n\n* Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.\n* Positive response to any question on the PAR-Q 2025 questionnaire.\n* Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.\n* Regular engagement in shift work.\n* Women who are pregnant or breastfeeding.",true,"ALL","18 Years","39 Years",{"count":189,"type":190},120,"ESTIMATED","INTERVENTIONAL",[193],"NA","The HyperLa study investigates whether a person's \"glycolyticness\"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized \"vLapeak\" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.",[196,197,198,199],"Healthy Volunteers","Muscle Hypertrophy","Glycolysis","Moderately Trainend",[201,202,203,204,205],"Resistance Training","vLapeak","Skeletal Muscle Adaptation","Metabolic Phenotyping","Exercise Physiology","2026-07-20",{"date":208,"type":209},"2026-07-23","ACTUAL",{"date":211,"type":209},"2026-05-04",{"date":213,"type":190},"2026-12-01",{"name":5,"class":6},8]