[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655433":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":33,"overallOfficials":17,"centralContacts":39,"locations":45,"responsibleParty":92,"collaborators":96,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":17,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":111,"studyType":112,"phases":17,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":48,"whyStopped":17,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"Tianjin Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Standardized uptake value (SUV)","Standardized uptake value (SUV) of 18F\u002F68Ga-GP1 for each target lesion of subject or suspected thrombi.","30 days",[14],{"measure":15,"description":16,"timeFrame":12},"Diagnostic efficacy","The sensitivity, specificity and accuracy of GPIIb\u002FIIIa PET\u002FCT were calculated.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","This clinical research project aims to visualize abnormal tau pathology in the living human brain using \\[18F\u002F68Ga\\]GP1 PET imaging. \\[18F\u002F68Ga\\]GP1 is a small molcule-based tracer that offers stronger binding affinity to GPIIb\u002FIIIa. The study primarily focuses on evaluating the safety and diagnostic efficacy of \\[18F\u002F68Ga\\]GP1 PET imaging in human subjects.","(i) adult patients (aged 18 years or order); (ii) patients with suspected or new diagnosed or previously treated thrombi (supporting evidence may include MRI, CT, tumor markers and pathology report); (iii) patients who had scheduled GPIIb\u002FIIIa PET\u002FCT scan; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee.",[24,29],{"label":25,"type":17,"description":26,"interventionNames":27},"Healthy participants","Participants will receive a single intravenous bolus injection of 10 ± 3 mCi of \\[18F\u002F68Ga\\]GP1 followed by a PET\u002FCT scan.",[28],"Diagnostic Test: 18F\u002F68Ga-GP1",{"label":30,"type":17,"description":31,"interventionNames":32},"Patients with thrombi","Participants will receive a single intravenous bolus injection of 10 ± 3 mCi of \\[18F\u002F68Ga\\]GP1 followed by a PET\u002FCT scan",[28],[34],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":17},"DIAGNOSTIC_TEST","18F\u002F68Ga-GP1","Each subject receive a single intravenous injection of 18F\u002F68Ga-GP1, and undergo PET\u002F CT or MRI imaging within the specificed time.",[25,30],[40],{"name":41,"role":42,"phone":43,"phoneExt":17,"email":44},"Haonan Yu, MD","CONTACT","+8613821000597","dreamadam@126.com",[46,65,80],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The First Affiliated Hospital of University of Science and Technology of China","RECRUITING","Hefei","Anhui","230000","China","CN",{"type":55,"coordinates":56},"Point",[57,58],117.28083,31.86389,{"lat":58,"lon":57},[61],{"name":62,"role":42,"phone":63,"phoneExt":17,"email":64},"Qiang Xie, PhD","+8613721108043","ahxq1980@163.com",{"facility":66,"status":48,"city":67,"state":68,"zip":69,"country":52,"countryCode":53,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"The Affiliated Hospital of Qingdao University","Qingdao","Shandong","266000",{"type":55,"coordinates":71},[72,73],120.38042,36.06488,{"lat":73,"lon":72},[76],{"name":77,"role":42,"phone":78,"phoneExt":17,"email":79},"Guangjie Yang, MD","+8617853297979","ygj_2815@qdu.edu.cn",{"facility":81,"status":48,"city":82,"state":83,"zip":84,"country":52,"countryCode":53,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Tianjin Medical University General Hospital","Tianjin","Tianjin Municipality","300052",{"type":55,"coordinates":86},[87,88],117.17667,39.14222,{"lat":88,"lon":87},[91],{"name":41,"role":42,"phone":43,"phoneExt":17,"email":44},{"type":93,"investigatorFullName":94,"investigatorTitle":95,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Shaobo Yao, PhD","Prof.",[97],{"name":81,"class":6},"100655433","glycoprotein-iibiiia-petct-in-various-gpiibiiia-related-disease-100655433",false,"NCT07813559","Glycoprotein IIb\u002FIIIa PET\u002FCT in Various GPIIb\u002FIIIa-Related Disease","Inclusion Criteria:\n\n* (i) adult patients (aged 18 years or order); (ii) patients with suspected or new diagnosed or previously treated thrombi (supporting evidence may include MRI, CT, tumor markers and pathology report); (iii) patients who had scheduled GPIIb\u002FIIIa PET\u002FCT scan; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee.\n\nExclusion Criteria:\n\n* (i) patients with non-thrombi lesions; (ii) patients with pregnancy; (iii) the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.",true,"ALL","18 Years","90 Years",{"count":109,"type":110},500,"ESTIMATED","7 Days","OBSERVATIONAL","In the field of diagnosing Thrombi diseases, it is now a well established practice to inject positron-emitting tracers into the human body.\n\nThese tracers bind to specific target proteins, allowing their distribution to be visualized via PET imaging. Currently, several research groups worldwide are engaged in developing and clinically validating their own GPIIb\u002FIIIa imaging agents.",[115,116,117],"Thrombi","Thrombus, Brain","Thrombus",[119,120,121,122],"PET\u002FCT","thrombus","thrombi","GPIIb\u002FIIIa receptors","2026-09-04",{"date":125,"type":126},"2026-09-10","ACTUAL",{"date":128,"type":126},"2026-09-01",{"date":130,"type":110},"2031-09-01",{"name":5,"class":6},3]