[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626515":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":63,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":25,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":25,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":25,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Miami","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Reminder-Only Group","EXPERIMENTAL","Participants in this group will receive a standard screening reminder via mailed letter or, if they have an active patient portal account through the University of Miami health (UHealth) portal.\n\nTotal participation duration is approximately nine (9) months.",[13],"Behavioral: Screening Reminder",{"label":15,"type":10,"description":16,"interventionNames":17},"Reminder + Blood-Based Option Group","Participants in this group will receive a similar reminder, but with the additional option of completing a blood-based screening test (ShieldTM). Communication will be delivered via mailed letter or the UHealth patient portal.\n\nTotal participation duration is approximately nine (9) months.",[13,18],"Procedure: Blood Sample Collection",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Screening Reminder","Participants will receive a standard screening reminder for colorectal cancer screening via mailed letter, or via University of Miami health (UHealth) portal if they have an active active account.",[15,9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"PROCEDURE","Blood Sample Collection","Participants who consent to the Shield TM by Guardant screening test, will undergo blood sample collection. Approximately 40 mL of blood will be drawn at a UHealth facility into a collection tube provided by Guardant Health.",[15],[32],{"name":33,"affiliation":5,"role":34},"Shria Kumar, MD, MSCE","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Helen Kattoura","CONTACT","(305) 243-6438","hkattoura@miami.edu",{"name":33,"role":38,"phone":25,"phoneExt":25,"email":42},"shriakumar@med.miami.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Miami","Florida","33136","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-80.19366,25.77427,{"lat":55,"lon":54},[58,59,60,61],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},{"name":33,"role":38,"phone":25,"phoneExt":25,"email":42},{"name":33,"role":34,"phone":25,"phoneExt":25,"email":25},{"name":62,"role":34,"phone":25,"phoneExt":25,"email":25},"Austin R Dosch, MD, PhD",{"type":34,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Shria Kumar","Associate Professor of Clinical",[67],{"name":68,"class":69},"Guardant Health, Inc.","INDUSTRY","100626515","guardant-shield-colorectal-cancer-screening-100626515",false,"NCT07436637","Guardant Shield Colorectal Cancer Screening","Using Guardant ShieldTM to Facilitate Colorectal Cancer Screening in Under-screened Individuals in a Diverse Patient Population","Inclusion Criteria:\n\n* Adults 45 - 85 years of age at average risk and able to provide informed consent.\n* Patients overdue for a screening colonoscopy or stool-based test that was ordered by their University of Miami (UM) clinician.\n\nExclusion Criteria:\n\n* Impaired decision-making capability\u002Funable to provide informed consent.\n* Patients with high-risk conditions:\n\n  * Personal history of colorectal cancer (CRC), adenomas, or other cancers\n  * Those who had a positive result on another CRC screening method within the last six months, an abnormal stool test that found blood in your stool within the last 12 months, or abnormal Cologuard (FIT-DNA Test) in the last 3 years\n  * Those with Inflammatory Bowel Disease (IBD), chronic ulcerative colitis (CUC), Crohn's disease\n  * Those who have a family history of colorectal cancer (in a parent, brother, sister, or child)\n  * Genetic predisposition requiring more frequent screening (such as Lynch syndrome, IBD, history of colectomy, etc.)\n  * Symptoms like rectal bleeding, weight loss, or other signs for which your doctor ordered a colonoscopy - not simply as a screening tool",true,"ALL","45 Years","85 Years",{"count":82,"type":83},500,"ESTIMATED","INTERVENTIONAL",[86],"NA","The purpose of this research is to identify individuals overdue for colon cancer screening and send them a reminder to complete their screening, which includes standard of care colonoscopy or stool-based testing. The investigators are randomizing patients (like a flip of a coin) to either receive the standard reminder by mail\u002Femail or to receive the standard reminder and have the option to provide a blood sample for screening (ShieldTM by Guardant).",[89],"Colorectal Cancer","2026-07-23",{"date":92,"type":93},"2026-07-27","ACTUAL",{"date":95,"type":93},"2026-07-22",{"date":97,"type":83},"2027-04-01",{"name":5,"class":6},1]