[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633629":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":24,"locations":34,"responsibleParty":262,"collaborators":266,"id":270,"slug":271,"hasResults":272,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":7,"eligibilityCriteria":276,"healthyVolunteers":272,"sex":277,"minAge":278,"maxAge":279,"enrollmentInfo":280,"targetDuration":283,"studyType":284,"phases":7,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":37,"whyStopped":7,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":300},{"fullName":5,"class":6},"Guven Health Group","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DRUG","Antiviral","Patients who take all antivirals recommended in the guidelines will be evaluated in the same group.",[14],"Nucleoz(t)ide antivirals",[16,20],{"name":17,"affiliation":18,"role":19},"Yasar Bayındır, MD, Prof.","Guven Hospital","STUDY_DIRECTOR",{"name":21,"affiliation":22,"role":23},"cigdem Mermutluoglu","Dicle University, Medical Faculty","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":7,"email":29},"Cigdem Mermutluoglu, MD, Assoc. Prof.","CONTACT","+905052252700","cigdemmermut@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":7,"email":33},"Mustafa Kemal Celen, MD, Prof.","+905336207022","yasarb44@hotmail.com",[35,55,69,80,95,107,118,132,148,162,173,189,206,220,234,248],{"facility":36,"status":37,"city":38,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Cukurova University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","RECRUITING","Adana","Turkey (Türkiye)",{"type":41,"coordinates":42},"Point",[43,44],35.32531,36.98615,{"lat":44,"lon":43},[47,51,52],{"name":48,"role":27,"phone":49,"phoneExt":7,"email":50},"Yesim Tasova, MD, Prof.","+905353088511","ytasova@gmail.com",{"name":48,"role":23,"phone":7,"phoneExt":7,"email":7},{"name":53,"role":54,"phone":7,"phoneExt":7,"email":7},"Suheyla Komur, MD, Prof.","SUB_INVESTIGATOR",{"facility":56,"status":37,"city":57,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Ankara Gazi University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Ankara",{"type":41,"coordinates":59},[60,61],32.85427,39.91987,{"lat":61,"lon":60},[64,68],{"name":65,"role":27,"phone":66,"phoneExt":7,"email":67},"Yesim Yildiz, MD, Assoc. Prof.","+905556109871","ysmyldz6@gmail.com",{"name":65,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":70,"status":37,"city":57,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"Bilkent City Hospital Department of Infectious Diseases and Clinical Microbiology",{"type":41,"coordinates":72},[60,61],{"lat":61,"lon":60},[75,79],{"name":76,"role":27,"phone":77,"phoneExt":7,"email":78},"Aliye Bastug, MD, Prof.","+905333814223","dr.aliye@yahoo.com",{"name":76,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":81,"status":37,"city":82,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Akdeniz University, Faculty of Medicine, Department of Infectious Diseases and Clinical Mİcrobiology","Antalya",{"type":41,"coordinates":84},[85,86],30.69556,36.90812,{"lat":86,"lon":85},[89,93],{"name":90,"role":27,"phone":91,"phoneExt":7,"email":92},"Dilara Inan, MD, Prof.","+905323706725","dilarainan2004@yahoo.com",{"name":94,"role":23,"phone":7,"phoneExt":7,"email":7},"Dılara Inan, MD, Prof.",{"facility":96,"status":37,"city":97,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Dicle University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Diyarbakır",{"type":41,"coordinates":99},[100,101],40.21721,37.91363,{"lat":101,"lon":100},[104,105],{"name":26,"role":27,"phone":28,"phoneExt":7,"email":29},{"name":31,"role":27,"phone":32,"phoneExt":7,"email":106},"mkcelen@hotmail.com",{"facility":108,"status":37,"city":97,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":109,"geoPoint":111,"contacts":112},"Diyarbakir, Memorial Hospital Department of Infectious Diseases and Clinical Microbiology",{"type":41,"coordinates":110},[100,101],{"lat":101,"lon":100},[113,117],{"name":114,"role":27,"phone":115,"phoneExt":7,"email":116},"Yakup Demir, MD","+905446540047","yakupdemir36@gmail.com",{"name":114,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":119,"status":37,"city":120,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Bolu Düzce University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Düzce",{"type":41,"coordinates":122},[123,124],31.16389,40.83889,{"lat":124,"lon":123},[127,131],{"name":128,"role":27,"phone":129,"phoneExt":7,"email":130},"Nevin Ince, MD, Assoc. Prof.","+905053505839","drnevince@gmail.com",{"name":128,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":133,"status":37,"city":134,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Gaziantep University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Gaziantep",{"type":41,"coordinates":136},[137,138],37.3825,37.05944,{"lat":138,"lon":137},[141,145,146],{"name":142,"role":27,"phone":143,"phoneExt":7,"email":144},"Ayse Ozlem Mete, MD, Assoc. Prof.","+905064883309","ayseozlem_ornek@hotmail.com",{"name":142,"role":23,"phone":7,"phoneExt":7,"email":7},{"name":147,"role":54,"phone":7,"phoneExt":7,"email":7},"Ilkay Karaoglan, MD, Prof.",{"facility":149,"status":37,"city":150,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Istanbul Haydarpaşa Numune Training and Research Hospital","Istanbul",{"type":41,"coordinates":152},[153,154],28.94966,41.01384,{"lat":154,"lon":153},[157,161],{"name":158,"role":27,"phone":159,"phoneExt":7,"email":160},"Seniha Senbayrak, MD, Prof.","+905055618792","senihasen@gmail.com",{"name":158,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":163,"status":37,"city":150,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":164,"geoPoint":166,"contacts":167},"Istanbul Sancaktepe Martyr Prof. Dr. İlhan Varank Training and Research Hospital",{"type":41,"coordinates":165},[153,154],{"lat":154,"lon":153},[168,172],{"name":169,"role":27,"phone":170,"phoneExt":7,"email":171},"Eyup Arslan, MD","+905324972976","dreyuparslan@hotmail.com",{"name":169,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":174,"status":37,"city":175,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Ege University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Izmir",{"type":41,"coordinates":177},[178,179],27.13838,38.41273,{"lat":179,"lon":178},[182,186,187],{"name":183,"role":27,"phone":184,"phoneExt":7,"email":185},"Husnu Pullukcu, MD, Prof.","+905334231918","husnup@yahoo.com",{"name":183,"role":23,"phone":7,"phoneExt":7,"email":7},{"name":188,"role":54,"phone":7,"phoneExt":7,"email":7},"Tansu Yamazhan, MD, Prof.",{"facility":190,"status":37,"city":191,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Kocaeli University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Kocaeli",{"type":41,"coordinates":193},[194,195],27.51145,39.62497,{"lat":195,"lon":194},[198,202,204],{"name":199,"role":27,"phone":200,"phoneExt":7,"email":201},"Sıla Akhan, MD, Prof.","+905322666535","silaakhan@gmail.com",{"name":203,"role":54,"phone":7,"phoneExt":7,"email":7},"Muge Toygar Deniz, MD, Assoc. Prof.",{"name":205,"role":23,"phone":7,"phoneExt":7,"email":7},"Sila Akhan, MD, Assoc. Prof.",{"facility":207,"status":37,"city":208,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Rize Recep Tayyip Erdogan University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Rize",{"type":41,"coordinates":210},[211,212],40.52194,41.02083,{"lat":212,"lon":211},[215,219],{"name":216,"role":27,"phone":217,"phoneExt":7,"email":218},"Ilknur Esen Yildiz, MD, Assoc. Prof.","+905057954452","iesenyildiz61@gmail.com",{"name":216,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":221,"status":37,"city":222,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Samsun Ondokuz Mayıs University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Samsun",{"type":41,"coordinates":224},[225,226],36.3361,41.27976,{"lat":226,"lon":225},[229,233],{"name":230,"role":27,"phone":231,"phoneExt":7,"email":232},"Ozgur Gunal, MD, Prof.","+905052543167","ozgurgop@yahoo.com",{"name":230,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":235,"status":37,"city":236,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"Şanlıurfa Harran University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Sanliurfa",{"type":41,"coordinates":238},[239,240],38.79392,37.16708,{"lat":240,"lon":239},[243,247],{"name":244,"role":27,"phone":245,"phoneExt":7,"email":246},"Tuba Damar Cakirca, MD, Prof.","+905444495379","dr.tubadamar@gmail.com",{"name":244,"role":23,"phone":7,"phoneExt":7,"email":7},{"facility":249,"status":37,"city":250,"state":7,"zip":7,"country":39,"countryCode":7,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Sivas Cumhuriyet University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology","Sivas",{"type":41,"coordinates":252},[253,254],37.01611,39.74833,{"lat":254,"lon":253},[257,261],{"name":258,"role":27,"phone":259,"phoneExt":7,"email":260},"Seyit Ali Buyuktuna, MD, Prof.","+905053869882","alibuyuktuna@gmail.com",{"name":258,"role":23,"phone":7,"phoneExt":7,"email":7},{"type":263,"investigatorFullName":264,"investigatorTitle":265,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Yaşar Bayındır, MD","Chief Physican",[267],{"name":268,"class":269},"SOUTHEAST NEUROLOGY AND INFECTIOUS DISEASES SOCIETY","UNKNOWN","100633629","hbv-reactivation-in-immunocompromised-patients-reant-study-100633629",false,"NCT07529171","HBV Reactivation in Immunocompromised Patients (REANT STUDY)","Management and Monitoring of HBV Reactivation in Immunocompromised Patients in Turkey (REANT STUDY)","Inclusion Criteria:\n\n* Aged 18 years or older\n* Positive for Anti-HBc IgG\n* Must be candidate for immunosuppressive therapy.\n\nExclusion Criteria:\n\n* Voluntary Withdrawal\n* Failure to attend follow-up visits","ALL","18 Years","80 Years",{"count":281,"type":282},490,"ESTIMATED","48 Months","OBSERVATIONAL","Background\u002FObjective: Comorbidities represent a critical risk factor in the prognosis of patients receiving immunosuppressive therapy. For patients with anti-HBc IgG positivity requiring Hepatitis B virus (HBV) prophylaxis, the long-term physiological impact of oral antivirals remains a concern. This study aims to prospectively monitor bone, renal, and metabolic dysfunctions associated with oral antiviral use and other systemic risk factors over a long-term period.\n\nMethods: The REANT Cohort is designed as a 4-year, multicenter prospective study. The cohort will consist of patients initiated on HBV prophylaxis due to immunosuppressive treatment. Participants will undergo regular longitudinal assessments to evaluate bone mineral density, renal filtration and tubular functions, and metabolic profiles. The interplay between antiviral therapy, baseline comorbidities, and long-term organ dysfunction will be analyzed.\n\nConclusion: The findings from the REANT Cohort are expected to provide robust evidence regarding the safety of long-term HBV prophylaxis and assist in the development of monitoring guidelines for immunosuppressed patients with latent HBV infection.",[287],"HBV",[289,290],"HBV reactivation","Immunosuppressive therapy","2026-08-01",{"date":293,"type":294},"2026-08-04","ACTUAL",{"date":296,"type":294},"2026-03-09",{"date":298,"type":282},"2029-12-31",{"name":264,"class":6},16]