[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652775":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":22,"locations":28,"responsibleParty":54,"collaborators":56,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":82,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Beijing Friendship Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HCC group",null,"Patients who developed HCC within 5 years after enrollment",[13],"Other: No intervention (observational study)",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-HCC group","Patients who did not develop HCC within 5 years after enrollment",[13],[19],{"type":6,"name":20,"description":20,"armGroupLabels":21,"otherNames":10},"No intervention (observational study)",[9,15],[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Jialing Zhou","CONTACT","860+010-63138665","Jialingzhou2023@163.com",[29],{"facility":30,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Beijing Friendship Hospital, Capital Medical University","Beijing","Xicheng","100050","China","CN",{"type":37,"coordinates":38},"Point",[39,40],116.39723,39.9075,{"lat":40,"lon":39},[43,44,47,50,52],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},{"name":45,"role":25,"phone":10,"phoneExt":10,"email":46},"Junwei Li","lijuwei123@126.com",{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Jianping Li, Doctor of Medicine","PRINCIPAL_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Liang Wang, Doctor of Medicine",{"name":53,"role":49,"phone":10,"phoneExt":10,"email":10},"Liuyi Chang, Doctor of Medicine",{"type":55,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[57,60,62],{"name":58,"class":59},"Guangzhou Eight People's Hospital, Guangzhou Medical University","UNKNOWN",{"name":61,"class":59},"The NO.2 People's Hospital of Lanzhou",{"name":63,"class":59},"Yuncheng People's Hospital","100652775","hcc-risk-prediction-model-based-on-multimodal-data-in-chronic-hepatitis-b-100652775",false,"NCT07780357","HCC Risk Prediction Model Based on Multimodal Data in Chronic Hepatitis B","Development and Application of an HCC Risk Prediction Model Based on Multimodal Data in Chronic Hepatitis B","Inclusion Criteria:\n\n1. Aged ≥18 years, both sexes eligible.\n2. Diagnosed with hepatitis B-related liver fibrosis or cirrhosis based on clinical assessment or liver histopathology.\n3. Undergoing antiviral treatment.\n4. Follow-up duration between 0.5- 5 years.\n5. Availability of baseline data and at least two longitudinal follow-up visits.\n6. Clinical outcomes during the follow-up period are traceable.\n\nExclusion Criteria:\n\n1. Diagnosis of Hepatocellular carcinoma (HCC) or liver transplantation at baseline or within 6 months after baseline\u002Fenrollment.\n2. Coexisting other chronic liver diseases, such as genetic\u002Fmetabolic liver diseases, drug-induced liver injury, or severe steatotic liver disease.\n3. Coexisting other malignancies (except those considered cured).","ALL","18 Years",{"count":74,"type":75},2000,"ESTIMATED","OBSERVATIONAL","We propose to construct and validate an early HCC risk prediction model in a multicenter retrospective cohort of hepatitis B-related fibrosis\u002Fcirrhosis patients, using multimodal data encompassing longitudinal clinical data, serum glycomics profiles, and liver biopsy histopathological images.",[79],"Hepatocellular Carcinoma (HCC)",[81],"HCC, Risk Prediction Model, Multimodal Data, Chronic Hepatitis B","NOT_YET_RECRUITING","2026-08-19",{"date":85,"type":86},"2026-08-21","ACTUAL",{"date":88,"type":75},"2026-08-20",{"date":90,"type":75},"2028-12-31",{"name":5,"class":6},1]