[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654944":3},{"organization":4,"outcomesModule":7,"designInfo":48,"detailedDescription":57,"studyPopulation":47,"armGroups":58,"interventions":70,"overallOfficials":80,"centralContacts":84,"locations":93,"responsibleParty":109,"collaborators":47,"id":111,"slug":112,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":47,"eligibilityCriteria":117,"healthyVolunteers":113,"sex":118,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":47,"studyType":124,"phases":125,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":132,"whyStopped":47,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":47},[9],{"measure":10,"description":11,"timeFrame":12},"Change of Craving","Visual Analog Scale, range 0-100 point, the higher the score, the more one wants drugs.","baseline; The 2nd, 4th, 6th, 8th and 10th days during the intervention period; 4 weeks after treatment; 12 weeks after treatment",[14,18,22,25,28,31,35,38,41,43],{"measure":15,"description":16,"timeFrame":17},"impulsivity","Stop Single Task","baseline; 1 day after the treatment was completed",{"measure":19,"description":20,"timeFrame":21},"Negative reinforcement learning task","The negative reinforcement learning task was adopted to evaluate the patients' avoidance-avoidance behaviors and learning. By calculating and modeling, the avoidance-avoidance behavior bias (active avoidance bias ) and the learning rates based on different feedback: learning from successfully avoiding the aversive stimulus; learning from experiencing the aversive stimulus) were constructed.","baseline; 1 day after treatment was completed",{"measure":23,"description":24,"timeFrame":21},"Changes in Reward Learning","Reward Learning Task",{"measure":26,"description":27,"timeFrame":21},"Compulsory drinking","The Obsessive Compulsive Drinking Scale (OCDS) assesses compulsive thoughts and impulsive behaviors related to alcohol consumption. It consists of 14 items, each rated on a 5-point scale from 0 to 4. Scores ranging from 0 to 14 indicate almost no compulsive drinking characteristics, 15 to 28 indicate obvious compulsive thoughts or impulses, and scores above 29 indicate a significant compulsive drinking pattern with a high risk of relapse.",{"measure":29,"description":30,"timeFrame":21},"Depressive state","The depression assessment was conducted using the Patient Health Questionnaire - 9 (PHQ-9), which consists of 9 items, each representing a different aspect of depressive symptoms. Each item is scored on a 4-point scale. 0-4 points indicate no depressive symptoms, 5-9 points represent mild depression, 10-14 points indicate moderate depression, and scores above 15 indicate severe depression.",{"measure":32,"description":33,"timeFrame":34},"Anxiety state","The anxiety assessment was conducted using the Generalized Anxiety Disorder - 7 (GAD-7) self-rating scale. The core statistical indicator of this scale is the total score. The higher the score, the more severe the anxiety. A total score of 0-4 indicates no anxiety or the anxiety level is not clinically significant; a score of 5-9 represents mild anxiety; a score of 10-14 indicates moderate anxiety; and a score of 15 or above indicates severe anxiety.","baseline; 1 day after treatment was completed;",{"measure":36,"description":37,"timeFrame":17},"Sleeping conditions","The assessment was conducted using the Pittsburgh Sleep Quality Index (PSQI), with the total score ranging from 0 to 21. A higher score indicates poorer sleep quality.",{"measure":39,"description":40,"timeFrame":21},"EEG","EEG features such as event-related potentials (ERPs) and power spectral density (e.g., theta or alpha power)",{"measure":39,"description":42,"timeFrame":21},"change of functional connection of brain area",{"measure":44,"description":45,"timeFrame":46},"use of alcohol","Simple questionnaire to collect alcohol consumption and drinking frequency.","4 weeks after treatment; 12 weeks after treatment",null,{"allocation":49,"interventionModel":50,"interventionModelDescription":47,"primaryPurpose":51,"observationalModel":47,"timePerspective":47,"maskingInfo":52},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":53,"maskingDescription":47,"whoMasked":54},"DOUBLE",[55,56],"PARTICIPANT","OUTCOMES_ASSESSOR","This study conducted a multi-center randomized clinical controlled trial among individuals with alcohol use disorders, aiming to verify the effectiveness of accelerated HD-tACS in targeting the dorsolateral prefrontal cortex for the treatment of AUD. In particular, it aimed to assess the efficacy of accelerated HD-tACS in reducing alcohol craving and reducing relapse. Eligible patients were randomly divided into the accelerated HD-tACS group and the sham stimulation group in a 1:1 ratio. Clinical and electroencephalogram data were collected at baseline and after the intervention. Additionally, a follow-up assessment of alcohol consumption was conducted for all participants after the intervention ended.",[59,65],{"label":60,"type":61,"description":62,"interventionNames":63},"HD-tACS group","EXPERIMENTAL","Using the transcranial electrical stimulation device, with the ring-shaped focusing technology, the current is locked in the target area through a 4\\*1 electrode configuration, causing the peak to appear below the central electrode.",[64],"Device: HD-tACS",{"label":66,"type":67,"description":62,"interventionNames":68},"Sham HD-tACS group","SHAM_COMPARATOR",[69],"Device: Sham HD-tACS",[71,76],{"type":72,"name":73,"description":74,"armGroupLabels":75,"otherNames":47},"DEVICE","HD-tACS","The stimulation parameters are 40Hz and 2mA. The stimulation protocol is 20 minutes per session, 3 times per day, for a total of 10 consecutive days.",[60],{"type":72,"name":77,"description":78,"armGroupLabels":79,"otherNames":47},"Sham HD-tACS","The stimulation parameters are 40Hz and 2mA. The stimulation protocol is 20 minutes per session, 3 times per day, for a total of 10 consecutive days. At the commencement and conclusion of each therapeutic session, a 30-second ramp-up stimulation and a 30-second ramp-down stimulation (totaling 60 seconds) are administered, respectively, while the current output of the device is maintained at zero throughout the intervening interval.",[66],[81],{"name":82,"affiliation":5,"role":83},"Min Zhao","STUDY_CHAIR",[85,90],{"name":86,"role":87,"phone":88,"phoneExt":47,"email":89},"Haifeng Jiang","CONTACT","64387250","dragonjhf@hotmail.com",{"name":91,"role":87,"phone":88,"phoneExt":47,"email":92},"Tianzhen Chen","vomchan@hotmail.com",[94],{"facility":5,"status":47,"city":95,"state":96,"zip":97,"country":98,"countryCode":99,"cosmosGeoPoint":100,"geoPoint":105,"contacts":106},"Shanghai","Shanghai Municipality","200000","China","CN",{"type":101,"coordinates":102},"Point",[103,104],121.45806,31.22222,{"lat":104,"lon":103},[107],{"name":82,"role":87,"phone":88,"phoneExt":47,"email":108},"drminzhao@smhc.org.cn",{"type":110,"investigatorFullName":47,"investigatorTitle":47,"investigatorAffiliation":47,"oldNameTitle":47,"oldOrganization":47},"SPONSOR","100654944","hd-tacs-for-alcohol-use-disorder-100654944",false,"NCT07808190","HD-tACS for Alcohol Use Disorder","Accelerated High-Definition Transcranial Alternating Current Stimulation (HD-tACS) for Alcohol Use Disorder: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age range: 18-55 years old, gender not restricted;\n* Meets the DSM-5 diagnostic criteria for alcohol use disorder (moderate to severe);\n* AUDIT score ≥ 16;\n* Baseline score after alcohol cue-induced stimulation is ≥ 3;\n* Completed detoxification treatment before enrollment (moderate to severe), with detoxification duration of ≥ 7 days and ≤ 90 days;\n* Has a primary school education or above, and can understand and complete the research assessment;\n* Voluntarily participated in the study and signed the informed consent form.\n\nExclusion Criteria:\n\n* Currently, there are other substance use disorders (except nicotine);\n* Currently, there are schizophrenia, bipolar disorder or other severe psychotic disorders;\n* Has a history of epilepsy or family history of epilepsy;\n* Has a history of brain trauma, brain surgery or intracranial metal implants;\n* Has received electroconvulsive therapy (ECT), transcranial electrical\u002Fmagnetic\u002Fultrasound stimulation within the past 6 months;\n* Pregnant or lactating women;\n* Other situations that the researchers consider unsuitable for participation in this study.","ALL","18 Years","55 Years",{"count":122,"type":123},140,"ESTIMATED","INTERVENTIONAL",[126],"NA","This study aims to systematically explore the effectiveness of accelerated HD-tACS in treating AUD, particularly its efficacy in reducing alcohol craving and preventing relapse in AUD patients.",[129],"Alcohol Use Disorder",[131],"alcohol use disorder","NOT_YET_RECRUITING","2026-09-06",{"date":135,"type":136},"2026-09-08","ACTUAL",{"date":138,"type":123},"2026-09-01",{"date":140,"type":123},"2026-12-31",{"name":5,"class":6},1]