[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583918":3},{"organization":4,"outcomesModule":7,"designInfo":42,"detailedDescription":45,"studyPopulation":46,"armGroups":47,"interventions":53,"overallOfficials":41,"centralContacts":57,"locations":63,"responsibleParty":80,"collaborators":41,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":41,"enrollmentInfo":94,"targetDuration":97,"studyType":98,"phases":41,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":66,"whyStopped":41,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Soochow University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":41},[9],{"measure":10,"description":11,"timeFrame":12},"Rate of Major Adverse Cardiovascular Events","cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina","1 year",[14,17,20,23,26,29,33,36,37,39,40],{"measure":10,"description":15,"timeFrame":16},"ardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina","90 days",{"measure":18,"description":19,"timeFrame":16},"Functional Outcome","Percentage of patients with modified Rankin Scale (mRS) scores (minimum 0 and maximum 5) 3 to 5, who are considered to be disabled.",{"measure":21,"description":22,"timeFrame":12},"Rate of Ischemic Stroke","fatal and nonfatal ischemic stroke.",{"measure":24,"description":25,"timeFrame":12},"Rate of Acute Coronary Syndrome","fatal and nonfatal myocardial infarction and unstable angina",{"measure":27,"description":28,"timeFrame":12},"Rate of Cardiovascular Mortality","any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death",{"measure":30,"description":31,"timeFrame":32},"Time to First Major Adverse Cardiovascular Event","from the date of enrollment until the date of first documented cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction or unstable angina, whichever comes first, assessed up to 3 years","3 years",{"measure":34,"description":35,"timeFrame":32},"Time to First Ischemic Stroke","from the date of enrollment until the date of first documented ischemic stroke, assessed up to 3 years",{"measure":10,"description":11,"timeFrame":32},{"measure":21,"description":38,"timeFrame":32},"fatal and nonfatal ischemic stroke",{"measure":24,"description":25,"timeFrame":32},{"measure":27,"description":28,"timeFrame":32},null,{"allocation":41,"interventionModel":41,"interventionModelDescription":41,"primaryPurpose":41,"observationalModel":43,"timePerspective":44,"maskingInfo":41},"COHORT","PROSPECTIVE","There is growing evidence pointing to close interactions between acute ischemic stroke (AIS) and heart diseases. Heart diseases may lead to AIS (heart-to-brain interactions), with many cardiac conditions have been proposed as potential sources of cerebral embolism, and studies have also shown that AIS can induce cardiac injury (brain-to-heart interactions), namely Stroke-Heart Syndrome. In addition, due to the commonly shared risk factors, AIS patients had a significantly higher frequency of coexisting prior known or unknown coronary heart disease (brain-and-heart interactions). These heart problems not only add complexity to the etiological diagnosis but also account for a great proportionate mortality in AIS patients with reperfusion therapy, which is the most effective treatment method for AIS. The interconnected and coexisting properties of AIS and heart diseases requires a comprehensive scheme to evaluate, prevent, and treat patients.\n\nHeart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy.\n\nThis registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies.\n\nThe clinical, laboratory and imaging information will be collected at the baseline. During an estimated 3-year follow-up, the diagnostic or monitoring procedures, treatment, functional status and new vascular events will be recorded by web-based patients' self-reports, investigators' regular telephone visits.","Acute ischemic stroke patients within 24 h after onset of stroke-related symptoms.",[48],{"label":49,"type":41,"description":50,"interventionNames":51},"Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy","Acute ischemic stroke within 24 h after onset of stroke-related symptoms.",[52],"Other: observational only- no intervention",[54],{"type":6,"name":55,"description":55,"armGroupLabels":56,"otherNames":41},"observational only- no intervention",[49],[58],{"name":59,"role":60,"phone":61,"phoneExt":41,"email":62},"Jianqiang Ni, MD, PhD","CONTACT","+8617640052675","buildingdoc@163.com",[64],{"facility":65,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"The first affiliated hospital of soochow university","RECRUITING","Suzhou","Jiangsu","215000","China","CN",{"type":73,"coordinates":74},"Point",[75,76],120.59538,31.30408,{"lat":76,"lon":75},[79],{"name":59,"role":60,"phone":61,"phoneExt":41,"email":62},{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":84,"oldNameTitle":41,"oldOrganization":41},"PRINCIPAL_INVESTIGATOR","Jianqiang Ni","Clinical Professor","The First Affiliated Hospital of Soochow University","100583918","heart-evaluation-of-acute-ischemic-stroke-with-reperfusion-therapy-100583918",false,"NCT06882577","Heart Evaluation of Acute Ischemic Stroke With Reperfusion Therapy","HEART","Inclusion Criteria:\n\n1. Written informed consent by patient\n2. Age ≥ 18 years\n3. Acute ischemic stroke (with matching brain lesion on MR imaging)\n4. Enrolment within 24 h after onset of stroke-related symptoms.\n\nExclusion Criteria:\n\n1. Pregnancy and \u002F or breast-feeding.\n2. Participation in an interventional study.\n3. Patients refuse to participate in the research.","ALL","18 Years",{"count":95,"type":96},400,"ESTIMATED","12 Months","OBSERVATIONAL","Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy.\n\nThis registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies.",[101],"Acute Ischemic Stroke",[103,104,105],"Acute ischemic stroke","heart","Reperfusion Therapy","2025-05-12",{"date":108,"type":109},"2025-05-13","ACTUAL",{"date":111,"type":109},"2025-03-31",{"date":113,"type":96},"2029-03-31",{"name":5,"class":6},1]