[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647340":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":30,"centralContacts":38,"locations":43,"responsibleParty":58,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":91,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Nemocnice AGEL Trinec-Podlesi a.s.","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Resistant hypertension (≥3 antihypertensives incl. diuretic, sinus rhythm)",null,"Single cohort analysed by adherence status defined by TDM: adherent vs non-adherent.",[13,14,15],"Diagnostic Test: Heart rate variability recording (Polar H10) ·","Diagnostic Test: Therapeutic drug monitoring (antihypertensive drug levels)","Other: Questionnaires (MARS-CZ, PHQ-9, SF-36, IPAQ)",[17,22,26],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","Heart rate variability recording (Polar H10) ·","Short-term (10-15 min) seated HRV; time-domain (SDNN, RMSSD, pNN50) and frequency-domain (LF, HF, LF\u002FHF) parameters.",[9],{"type":18,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Therapeutic drug monitoring (antihypertensive drug levels)","Single blood draw measuring antihypertensive drug levels; defines adherent vs non-adherent status.",[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Questionnaires (MARS-CZ, PHQ-9, SF-36, IPAQ)","Self-completed instruments assessing medication adherence, mood, quality of life, and physical activity.",[9],[31,35],{"name":32,"affiliation":33,"role":34},"Jan Alexander Mohr, MD","Nemocnice AGEL Třinec-Podlesí a.s.","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":33,"role":37},"Matej Pekar, MD, PhD","STUDY_DIRECTOR",[39],{"name":32,"role":40,"phone":41,"phoneExt":10,"email":42},"CONTACT","+420724173927","jan.mohr@npo.agel.cz",[44],{"facility":33,"status":10,"city":45,"state":46,"zip":47,"country":48,"countryCode":10,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Třinec","Moravian-Silesian Region","739 61","Czechia",{"type":50,"coordinates":51},"Point",[52,53],18.67078,49.67763,{"lat":53,"lon":52},[56],{"name":32,"role":40,"phone":57,"phoneExt":10,"email":42},"+420 724 173 927",{"type":34,"investigatorFullName":36,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator",[61],{"name":62,"class":6},"Masaryk University","100647340","heart-rate-variability-and-medication-adherence-in-resistant-hypertension-100647340",false,"NCT07707583","Heart Rate Variability and Medication Adherence in Resistant Hypertension","Eart Rate Variability, Medication Adherence, and Blood Pressure Control in Resistant Hypertension: A Cross-Sectional Study","HRV-HYP-1","Inclusion Criteria:\n\n* Age 18-75 years with diagnosed essential hypertension\n* Treated with ≥3 antihypertensive drugs of different classes, including ≥1 diuretic (resistant hypertension)\n* Sinus rhythm\n* Able to give informed consent and understand Czech\n\nExclusion Criteria:\n\n* Absence of sinus rhythm: atrial fibrillation\u002Fflutter, ventricular arrhythmias, higher-degree AV block, pacemaker\u002FICD with sustained pacing, sustained SVT, or significant ectopy\n* Secondary hypertension\n* Pregnancy or breastfeeding\n* Cognitive impairment precluding informed consent","ALL","18 Years","75 Years",{"count":75,"type":76},150,"ESTIMATED","OBSERVATIONAL","This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in patients with resistant hypertension. Patients are recruited opportunistically, in a nurse-led manner, in a one-day-care cardiology unit, and undergo a single examination: a short-term HRV recording (Polar H10), a single blood draw for antihypertensive drug levels, office blood pressure, and self-completed questionnaires. There is no follow-up.",[80,81,82],"Resistant Hypertension","Medication Adherence","Autonomic Nervous System",[84,81,85,80,86,87,88,89,90],"Heart Rate Variability","Therapeutic Drug Monitoring","Autonomic Function","Compliance","HRV","Antihypertensive Agents","Blood Pressure","NOT_YET_RECRUITING","2026-07-13",{"date":94,"type":95},"2026-07-16","ACTUAL",{"date":97,"type":76},"2026-07-20",{"date":99,"type":76},"2027-12-31",{"name":5,"class":6},1]