[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648736":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":60,"collaborators":24,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":24,"enrollmentInfo":74,"targetDuration":24,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Technical University of Munich","OTHER",[8,14],{"label":9,"type":6,"description":10,"interventionNames":11},"Marathon runners","Marathon runners are expected to have no elevated troponin at baseline after 24 hours of rest",[12,13],"Diagnostic Test: Polyethylene glycol precipitation","Diagnostic Test: Transthoracic echocardiography",{"label":15,"type":6,"description":16,"interventionNames":17},"Patients with acute coronary syndrome","Troponin will be elevated in acute coronary syndrome per definition",[12,13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Polyethylene glycol precipitation","PEG will be assessed in patients with acute coronary syndrome upon presentation and before hospital discharge. Athletes will receive this intervention at baseline and within one hour after completion of the marathon",[9,15],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Transthoracic echocardiography","Patients with acute coronary syndrome will receive echocardiography upon presentation and before hospital discharge. Athletes will receive echocardiography at baseline and within one after marathon completion.",[9,15],[30],{"name":31,"affiliation":32,"role":33},"Simon Wernhart, MD, PhD","TUM - Technische Universität München","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":24,"email":38},"CONTACT","+491751830099","simon.wernhart@gmx.de",{"name":40,"role":36,"phone":41,"phoneExt":24,"email":42},"Sebastian Zenk, MD","+49821227800","sebastian.zenk@synlab.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":24,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Technical University Munich","RECRUITING","Munich","Bavaria","Germany","DE",{"type":52,"coordinates":53},"Point",[54,55],11.57549,48.13743,{"lat":55,"lon":54},[58,59],{"name":31,"role":36,"phone":37,"phoneExt":24,"email":38},{"name":40,"role":36,"phone":41,"phoneExt":24,"email":42},{"type":33,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PD Dr. med. Dr. rer. nat. Simon Wernhart","Principal Investigator","100648736","heartbeat-trop-polyethylene-glycol-precipitation-to-unmask-macrotroponin-100648736",false,"NCT07726420","HEARTBEAT-TROP. Polyethylene Glycol Precipitation to Unmask Macrotroponin","HEARTBEAT-TROP. Testing of Polyethylene Glycol Precipitation to Unmask Macrotroponin in Acute Coronary Syndrome and Marathon Runners.","MACRO-TROP","Inclusion Criteria:\n\n* Age above 18 years\n* Group with acute coronary syndrome (ACS): Diagnosis of ACS (ST-segment elevation or non-ST-segment elevation myocardial infarction according to the European Society of Cardiology Guidelines 2023 with at least one measurement of high sensitive troponin I or T above the 99th percentile of reference).\n* Marathon runners: Participation in a marathon following cardiological pre-participation screening and medical clearance for competition. No clinical signs of cardiovascular or structural heart disease\n\nExclusion Criteria:\n\n* Patients with acute coronary syndrome: Known macrotroponin, terminal renal disease (glomerular filtration rate below 10ml per minute), diagnosis of cancer, pregnancy\n* Marathon runners: Coronary artery disease, structural heart disease, diagnosis of cancer, pregnancy",true,"ALL","18 Years",{"count":75,"type":76},160,"ESTIMATED","INTERVENTIONAL",[79],"NA","Troponin elevation can, among others, be due to myocardial infarction, acute inflammation or structural heart disease. Formation of macrocomplexes against troponin is an underestimated cause for persistent troponin elevation. Polyethlylene glycol precipitation (PEG) can differentiate macrotroponin from real troponin elevation, but cut-off values for PEG have not been established. PEG is analyzed in patients with acute coronary syndrome undergoing invasive coronary angiography and compared to healthy marathon runners who have undergone cardiological pre-participation screening and have rested for 24 hours.",[82],"Diagnoses Disease",[84,85,86],"troponin","athletes","polyethylene glycol precipitation","2026-07-22",{"date":89,"type":90},"2026-07-24","ACTUAL",{"date":92,"type":90},"2026-07-15",{"date":94,"type":76},"2027-12-01",{"name":5,"class":6},1]