[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658045":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":49,"studyPopulation":38,"armGroups":50,"interventions":67,"overallOfficials":78,"centralContacts":82,"locations":91,"responsibleParty":108,"collaborators":38,"id":111,"slug":112,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":119,"sex":120,"minAge":121,"maxAge":38,"enrollmentInfo":122,"targetDuration":38,"studyType":125,"phases":126,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":93,"whyStopped":38,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},{"fullName":5,"class":6},"Brigham Young University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":23,"otherOutcomes":38},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Femoral artery endothelial function","Common femoral artery blood flow will be measured using Doppler ultrasound at rest and during passive movement of the lower leg through approximately 90 degrees of motion. The hyperemic response may be expressed as peak blood flow, change from resting blood flow, and\u002For blood-flow area under the curve. The change from baseline to post-intervention will be compared among groups.","This outcome will be assessed four days prior to the start of the intervention (Day -4) and again 1 day following the final sauna visit (Day 8)",{"measure":14,"description":15,"timeFrame":12},"Change in Maximum Knee-Extension Cycling Power","Maximum exercise power will be determined during a graded knee-extension cycling test in which resistance is progressively increased until the participant can no longer maintain the required cadence. Maximum power will be reported in watts.",{"measure":17,"description":18,"timeFrame":12},"Change in Whole-Body Lean Mass","Whole-body lean mass will be measured using dual-energy X-ray absorptiometry. Lean mass will be reported in kilograms, and the change from baseline to post-intervention will be compared among groups.",{"measure":20,"description":21,"timeFrame":22},"Integrated Skeletal Muscle Protein Synthesis Rate","The integrated fractional synthesis rate of skeletal muscle protein will be determined using deuterium oxide labeling and vastus lateralis muscle biopsies. Deuterium incorporation into newly synthesized muscle protein will be quantified by mass spectrometry and expressed as the fractional synthesis rate over the study period, such as percentage per day. Rates will be compared among the three intervention groups.","Baseline (Day -4) and Day 8",[24,27,31,34],{"measure":25,"description":26,"timeFrame":12},"Change in Leg Lean Mass","Regional leg lean mass will be measured using dual-energy X-ray absorptiometry and reported in kilograms. The change from baseline to post-intervention will be compared among groups.",{"measure":28,"description":29,"timeFrame":30},"Change in Mean Interstitial Glucose Concentration","Interstitial glucose concentrations will be monitored using a continuous glucose monitor. Mean glucose concentration will be calculated for the habitual-activity or baseline monitoring period and for the 7-day intervention period and reported in milligrams per deciliter.","Days -4, -3, -2, -1, 0, 1, 2, 3, 4, 5, 6, 7, 8",{"measure":32,"description":33,"timeFrame":30},"Mean Daily Step Count During the Intervention","Daily physical activity will be measured using an accelerometer worn on the wrist, ankle, or waist. Mean steps per day during the 7-day intervention will be used to assess adherence to the habitual-activity or reduced-activity assignment.",{"measure":35,"description":36,"timeFrame":37},"Change in Core Temperature During Sauna Exposure","Core temperature will be measured using an esophageal temperature probe during the first and final sauna treatments. The change from pre-sauna temperature to peak temperature during sauna will be reported in degrees Celsius.","Day 1 and Day 8",null,{"allocation":40,"interventionModel":41,"interventionModelDescription":42,"primaryPurpose":43,"observationalModel":38,"timePerspective":38,"maskingInfo":44},"RANDOMIZED","PARALLEL","Participants will be randomly assigned to one of three parallel groups for a 7-day intervention: (1) habitual physical activity with daily Finnish dry sauna therapy, (2) reduced physical activity (\\~1,000 steps\u002Fday) with daily room-temperature sauna visits (control), or (3) reduced physical activity (\\~1,000 steps\u002Fday) with daily Finnish dry sauna therapy. All participants will complete identical pre- and post-intervention outcome assessments.","PREVENTION",{"masking":45,"maskingDescription":46,"whoMasked":47},"SINGLE","Due to the nature of the interventions, participants and study personnel administering the interventions will not be masked to group assignment. When feasible, investigators performing outcome analysis will evaluate coded data without knowledge of participant group assignment.",[48],"OUTCOMES_ASSESSOR","Reduced physical activity resulting from illness, injury, hospitalization, or other temporary limitations rapidly impairs cardiovascular, skeletal muscle, and metabolic health. Even short-term reductions in daily physical activity are associated with decreased endothelial function, reduced aerobic capacity, loss of muscle mass, and impaired insulin sensitivity.\n\nPrevious work from our laboratory has demonstrated that localized heat therapy producing exercise-like increases in muscle temperature attenuates several detrimental adaptations associated with limb immobilization. The present study investigates whether whole-body heat therapy delivered through Finnish dry sauna bathing can similarly reduce the adverse effects of whole-body reductions in physical activity.\n\nHealthy adults will be randomly assigned to one of three intervention groups:\n\n* Habitual physical activity with daily Finnish dry sauna therapy\n* Reduced physical activity (\\~1,000 steps\u002Fday) with daily room-temperature sauna visits\n* Reduced physical activity (\\~1,000 steps\u002Fday) with daily Finnish dry sauna therapy\n\nThe intervention will last seven days. Cardiovascular function, exercise tolerance, muscle protein synthesis, body composition, glucose regulation, blood pressure, and additional physiological variables will be assessed before and after the intervention. The findings will determine whether passive heat therapy is an effective strategy for preserving cardiometabolic health during temporary reductions in physical activity.",[51,57,63],{"label":52,"type":53,"description":54,"interventionNames":55},"Habitual Physical Activity + Sauna","EXPERIMENTAL","Participants will maintain their habitual level of physical activity for seven consecutive days while undergoing one supervised Finnish dry sauna session each day. Sauna treatments will consist of standard Finnish dry sauna exposure according to the study protocol. Participants will undergo comprehensive cardiovascular, muscular, metabolic, and physiological assessments before and after the intervention.",[56],"Device: Sauna",{"label":58,"type":59,"description":60,"interventionNames":61},"Reduced Physical Activity + Room-Temperature Sauna (Control)","SHAM_COMPARATOR","Participants will reduce daily physical activity to approximately 1,000 steps per day for seven consecutive days with assistance from a power wheelchair. Participants will attend daily room-temperature sauna sessions that replicate the timing and environment of the sauna intervention without therapeutic heat exposure. Comprehensive outcome assessments will be completed before and after the intervention.",[62],"Behavioral: Reduced Physical Activity",{"label":64,"type":53,"description":65,"interventionNames":66},"Reduced Physical Activity + Dry Sauna","Participants will reduce daily physical activity to approximately 1,000 steps per day for seven consecutive days with assistance from a power wheelchair while also completing one supervised Finnish dry sauna session each day. Outcome measures will be assessed before and after the intervention to determine whether heat therapy attenuates the adverse physiological effects of reduced physical activity.",[56,62],[68,73],{"type":69,"name":70,"description":71,"armGroupLabels":72,"otherNames":38},"DEVICE","Sauna","Participants will complete one supervised dry sauna session each day for seven consecutive days. Sauna exposure will be delivered according to the study protocol using a standard Finnish dry sauna.",[52,64],{"type":74,"name":75,"description":76,"armGroupLabels":77,"otherNames":38},"BEHAVIORAL","Reduced Physical Activity","Participants will reduce daily step count to approximately 1,000 steps per day for seven consecutive days. A power wheelchair will be used to assist participants in minimizing ambulation while maintaining normal daily activities.",[64,58],[79],{"name":80,"affiliation":5,"role":81},"Robert D Hyldahl, PhD","PRINCIPAL_INVESTIGATOR",[83,87],{"name":80,"role":84,"phone":85,"phoneExt":38,"email":86},"CONTACT","8014221237","robhyldahl@byu.edu",{"name":88,"role":84,"phone":89,"phoneExt":38,"email":90},"Jayson R Gifford, PhD","8014223090","jaysongifford@byu.edu",[92],{"facility":5,"status":93,"city":94,"state":95,"zip":96,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":104,"contacts":105},"RECRUITING","Provo","Utah","84602","United States","US",{"type":100,"coordinates":101},"Point",[102,103],-111.65853,40.23384,{"lat":103,"lon":102},[106,107],{"name":80,"role":84,"phone":85,"phoneExt":38,"email":86},{"name":88,"role":84,"phone":89,"phoneExt":38,"email":90},{"type":81,"investigatorFullName":109,"investigatorTitle":110,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"Rob Hyldahl","Associate Professor","100658045","heat-therapy-during-reduced-physical-activity-100658045",false,"NCT07847424","Heat Therapy During Reduced Physical Activity","Can Heat Therapy Improve Cardiovascular Health During Periods of Reduced Physical Activity?","HEAT-RPA","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Healthy men and premenopausal women\n* Able and willing to provide written informed consent\n* Able to perform knee-extension cycling exercise\n* Stable habitual physical activity for at least 3 months before enrollment\n* Pass the American College of Sports Medicine (ACSM) Preparticipation Health Screening\n* Not currently taking medications known to affect cardiovascular function (e.g., antihypertensive medications or beta-blockers)\n* No regular sauna or hot-tub use (fewer than six exposures during the previous 2 months)\n* Willing and able to comply with all study procedures, including temporary reduction of physical activity, daily sauna visits, physiological testing, and follow-up assessments\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Failure to pass the ACSM Preparticipation Health Screening\n* Unable or unwilling to perform exercise testing\n* Current cigarette or marijuana use\n* Pregnant or planning to become pregnant during the study\n* History or current diagnosis of cardiovascular disease, metabolic disease, or cognitive impairment\n* Use of medications known to influence cardiovascular function or exercise tolerance (e.g., antihypertensive medications or beta-blockers)\n* Regular sauna or hot-tub use (six or more exposures during the previous 2 months)\n* History of heat-related illness\n* Any condition that, in the opinion of the investigators, would interfere with safe participation or interpretation of study results\n* Inability to understand the study procedures or provide informed consent",true,"ALL","18 Years",{"count":123,"type":124},60,"ESTIMATED","INTERVENTIONAL",[127],"NA","The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical activity in healthy adults.\n\nParticipants will be randomized to one of three groups: (1) maintained habitual physical activity with daily sauna therapy, (2) reduced physical activity with daily room-temperature sauna visits (control), or (3) reduced physical activity with daily sauna therapy. Reduced physical activity will be achieved by decreasing daily step count to approximately 1,000 steps per day with the assistance of a power wheelchair.\n\nOutcome measures include vascular endothelial function, exercise tolerance, muscle protein synthesis, body composition, blood pressure, glucose regulation, and physiological responses to heat exposure. The study will determine whether passive heat therapy can serve as a practical intervention to preserve cardiometabolic health during short periods of reduced mobility.",[130,131,132],"Physical Inactivity","Vascular Dysfunction","Skeletal Muscle Atrophy",[134,130,70,135,136,137],"Heat Therapy","Disuse","Protein Synthesis","Vascular Health","2026-09-28",{"date":140,"type":141},"2026-09-29","ACTUAL",{"date":143,"type":141},"2026-01-01",{"date":145,"type":124},"2027-05",{"name":5,"class":6},1]