[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655086":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":27,"studyPopulation":28,"armGroups":29,"interventions":23,"overallOfficials":33,"centralContacts":38,"locations":23,"responsibleParty":44,"collaborators":23,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":23,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":23,"briefSummary":63,"conditions":64,"keywords":70,"overallStatus":76,"whyStopped":23,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":23},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Frequency of hematological abnormalities","Proportion of children with numerical chromosomal disorders who have one or more hematological abnormalities (anemia, macrocytosis, thrombocytopenia, leukopenia, leukocytosis, or abnormal peripheral blood smear findings), expressed as percentage.","Baseline",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Pattern of hematological abnormalities","Distribution and pattern of specific hematological abnormalities (anemia, macrocytosis, thrombocytopenia, neutropenia, etc.) among the studied children.",{"measure":18,"description":19,"timeFrame":12},"Hematological profile according to syndrome type","Comparison of hematological parameters (hemoglobin, MCV, platelet count, white blood cell count) among different numerical chromosomal disorders (Down syndrome, Turner syndrome, and others).",{"measure":21,"description":22,"timeFrame":12},"Correlation of hematological abnormalities with clinical features","Correlation coefficient between the presence of hematological abnormalities and clinical features (recurrent infections, bleeding manifestations, hepatosplenomegaly), using Spearman or Pearson correlation as appropriate.",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"CASE_ONLY","CROSS_SECTIONAL","Numerical chromosomal disorders such as Down syndrome, Turner syndrome, Klinefelter syndrome, Edwards syndrome, and Patau syndrome are associated with various hematological abnormalities. These may include anemia, macrocytosis, thrombocytopenia, leukocyte abnormalities, and increased risk of hematological malignancies, particularly in Down syndrome.\n\nThis cross-sectional study will include children aged 28 days to 18 years with confirmed numerical chromosomal disorders. Complete blood count and peripheral blood smear examination will be performed to evaluate the hematological profile and determine the frequency and pattern of abnormalities.","Children aged 28 days to 18 years diagnosed with numerical chromosomal disorders attending the Pediatric Department of Assiut University Children's Hospital.",[30],{"label":31,"type":23,"description":32,"interventionNames":23},"Single cohort: Children with numerical chromosomal disorders","Children aged 28 days to 18 years with confirmed numerical chromosomal disorders who will undergo complete blood count and peripheral blood smear examination to evaluate their hematological profile.",[34],{"name":35,"affiliation":36,"role":37},"Mohamed M Hamdy, prof","Pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[39],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},"Dalia a Sayed, Resident","CONTACT","+20 11 54130609","Dalia.18331747@med.aun.edu.eg",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Dalia Abdo Abdelhafez Sayed","Resident Physician","100655086","hematological-profile-in-children-with-numerical-chromosomal-disorders-100655086",false,"NCT07807540","Hematological Profile in Children With Numerical Chromosomal Disorders","Evaluation of Hematological Profile in Children With Numerical Chromosomal Disorders","Inclusion Criteria:\n\n* \\- Age from 28 days to 18 years\n* Confirmed numerical chromosomal disorder (Down syndrome, Turner syndrome, Klinefelter syndrome, Edwards syndrome, or Patau syndrome) by karyotype\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* \\- Age below 28 days\n* Patients receiving chemotherapy\n* Refusal of parents or legal guardians to participate","ALL","28 Days","18 Years",{"count":59,"type":60},158,"ESTIMATED","1 Day","OBSERVATIONAL","This cross-sectional study aims to evaluate the hematological profile and determine the frequency and pattern of hematological abnormalities in children with numerical chromosomal disorders attending the Pediatric Department of Assiut University Children's Hospital.",[65,66,67,68,69],"Down Syndrome","Turner Syndrome","Klinefelter Syndrome","Trisomy 18","Chromosome Disorders",[71,72,73,74,75],"Numerical chromosomal disorders","Hematological profile","Down syndrome","Complete blood count","Children","NOT_YET_RECRUITING","2026-09-05",{"date":79,"type":80},"2026-09-10","ACTUAL",{"date":82,"type":60},"2026-09-02",{"date":84,"type":60},"2028-07-20",{"name":5,"class":6}]