[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653108":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":26,"studyPopulation":13,"armGroups":27,"interventions":40,"overallOfficials":48,"centralContacts":52,"locations":13,"responsibleParty":62,"collaborators":13,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":13,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":13,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":13,"overallStatus":83,"whyStopped":13,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":13},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Heart rate accompanying laryngoscopy and tracheal intubation with cuff inflation","Assessed in beats per minute","The fifth minute after laryngoscopy and tracheal intubation with cuff inflation",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":19,"maskingDescription":20,"whoMasked":21},"QUADRUPLE","Double (Participant, Care Provider, Investigator, Outcomes Assessor)",[22,23,24,25],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR","Various prophylactic interventions have been tried to blunt the hemodynamic stress response to laryngoscopy and tracheal intubation. The ketamine-dexmedetomidine combination (ketodex) and ketamine-propofol combination (ketofol) may be of benefit in maintaining hemodynamic stability and reducing potential side effects of each drug.",[28,34],{"label":29,"type":30,"description":31,"interventionNames":32},"Ketodex","ACTIVE_COMPARATOR","Patients will receive a single IV bolus dose of both ketamine and dexmedetomidine",[33],"Drug: ketodex",{"label":35,"type":36,"description":37,"interventionNames":38},"Ketofol","PLACEBO_COMPARATOR","Patients will receive a single IV bolus dose of both ketamine and propofol",[39],"Drug: ketofol",[41,45],{"type":42,"name":43,"description":31,"armGroupLabels":44,"otherNames":13},"DRUG","ketodex",[29],{"type":42,"name":46,"description":37,"armGroupLabels":47,"otherNames":13},"ketofol",[35],[49],{"name":50,"affiliation":5,"role":51},"Seham M Moeen, M.D.","PRINCIPAL_INVESTIGATOR",[53,58],{"name":50,"role":54,"phone":55,"phoneExt":56,"email":57},"CONTACT","01006386324","02","seham.moeen@aun.edu.eg",{"name":59,"role":54,"phone":60,"phoneExt":56,"email":61},"Mohammed F Aly","01002610390","rescu2016@aun.edu.eg",{"type":51,"investigatorFullName":63,"investigatorTitle":5,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Seham Mohamed Moeen Ibrahim","100653108","hemodynamic-responses-to-laryngoscopy-and-tracheal-intubation-100653108",false,"NCT07783256","Hemodynamic Responses to Laryngoscopy and Tracheal Intubation","Effectiveness of Intravenous Ketodex Versus Ketofol for Obtunding Hemodynamic Responses to Laryngoscopy and Tracheal Intubation in Adult Elective Middle Ear Surgery Patients: A Prospective Randomized Comparative Study","Inclusion Criteria:\n\n* Adult patients scheduled for elective middle ear surgery under general anesthesia, ASA status I-II, aged from 18 to 60 years old of either sex.\n\nExclusion Criteria:\n\n* Full stomach or emergency surgery\n* Any known contraindications or allergy to ketamine, dexmedetomidine, or propofol\n* Pregnancy or breastfeeding women\n* Body mass index (BMI) \\> 35 Kg\u002Fm2\n* History of hepatic, renal, or cardiac disease\n* Patients in whom the duration of laryngoscopy will last more than 25 seconds\n* Chronic opioid use, or history of neuropsychiatric disorders\n* Patient refusal","ALL","18 Years","60 Years",{"count":75,"type":76},70,"ESTIMATED","INTERVENTIONAL",[79],"NA","Laryngoscopy and tracheal intubation lead to tachycardia and hypertension due to increase in the plasma catecholamines subsequent to sympathetic stimulation.",[82],"Hemodynamic Response to Laryngoscopy and Tracheal Intubation","NOT_YET_RECRUITING","2026-08-20",{"date":86,"type":87},"2026-08-24","ACTUAL",{"date":89,"type":76},"2026-12-20",{"date":91,"type":76},"2028-12-20",{"name":5,"class":6}]