[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641069":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":49,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":28,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intraoperative application of high-density flexible μECoG-Guided Resection","EXPERIMENTAL",null,[13],"Device: Using High-density Flexible microElectrocorticography for intraoperative monitoring",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","Using High-density Flexible microElectrocorticography for intraoperative monitoring","During resective epilepsy surgery, a sterile high-density flexible microelectrocorticography will be placed on the exposed cortical surface over the suspected epileptogenic zone and adjacent cortex. The array will be used for high-spatial-resolution intraoperative μECoG recording and real-time analysis of epileptiform activity, including interictal spikes, high-frequency oscillations, spatial discharge gradients, and propagation patterns. The intraoperative ECoG findings will be provided to the surgical team to assist in defining the epileptogenic zone and tailoring the extent of resection. The high-density μECoG is used for intraoperative recording only and will be removed before wound closure.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Kai Zhang Dr","CONTACT","86 01059975051","zhangkai62035@sina.com",[27],{"facility":5,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Beijing","Beijing Municipality","100070","China","CN",{"type":35,"coordinates":36},"Point",[37,38],116.39723,39.9075,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":24,"phoneExt":11,"email":43},"Du Cai Dr","ferryc22@163.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":48,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Kai Zhang","Director of the Department of Neurosurgery, Clinical Professor","Beijing Neurosurgical Institute",[50,53,55,57,59],{"name":51,"class":52},"Beijing Fengtai Hospital","UNKNOWN",{"name":54,"class":6},"Peking University First Hospital",{"name":56,"class":6},"The Chinese University of Hong Kong, Shenzhen",{"name":58,"class":52},"Beijing Xinzhida Neural Technology Co., Ltd",{"name":48,"class":6},"100641069","high-density-flexible-ecog-for-epilepsy-surgery---a-single-arm-ect-100641069",false,"NCT07656857","High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT","Precision Resection of the Epileptogenic Zone Using Intraoperative Submillimeter Micro-Electrocorticography (Epi-PRECISE): A Single-Arm Trial With an External Historical Control Cohort","Epi-PRECISE","Inclusion Criteria:\n\n1. Age 3 to 60 years.\n2. Diagnosis of drug-resistant epilepsy, defined as persistent seizures despite treatment with two or more appropriately selected, adequately dosed and adequately tried antiseizure medications.\n3. Diagnosis of focal epilepsy after standard presurgical evaluation and considered suitable for resective epilepsy surgery.\n4. Preoperative cognitive or developmental status sufficient to participate in study assessments, as judged by the investigator and assessed using age-appropriate validated instruments. For participants aged 3 to 6 years, developmental status must be within the normal range according to the Griffiths Mental Development Scales. For participants aged 6 to 16 years, cognitive function must be within the normal range according to the Wechsler Intelligence Scale for Children. For participants older than 16 years, a Mini-Mental State Examination score of 24 or higher will be required.\n5. Written informed consent provided by the participant or, when applicable, by a legal guardian.\n\nExclusion Criteria:\n\n1. Suspected mesial temporal lobe epilepsy after multidisciplinary presurgical evaluation.\n2. History of any previous neurosurgical craniotomy before epilepsy surgery.\n3. Severe psychiatric, cognitive, or psychological disorder that prevents participation in the study or completion of follow-up.\n4. Contraindication to surgery.","ALL","3 Years","60 Years",{"count":72,"type":73},85,"ESTIMATED","INTERVENTIONAL",[76],"NA","What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?",[79,80],"Focal Epilepsy","Intraoperative Monitoring",[82,83],"Epilepsy surgery","microelectrocorticography (μECoG)","2026-08-12",{"date":86,"type":87},"2026-08-13","ACTUAL",{"date":89,"type":73},"2026-09-01",{"date":91,"type":73},"2028-12-31",{"name":5,"class":6},1]