[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615383":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":20,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":20,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":20,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":20,"overallStatus":71,"whyStopped":20,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"British Columbia Cancer Agency","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Dose RT","EXPERIMENTAL","27Gy in 3 fractions with boost",[13],"Radiation: Palliative Radiotherapy",[15,21],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"RADIATION","Palliative Radiotherapy","standard dose RT",[9],null,{"type":16,"name":17,"description":22,"armGroupLabels":23,"otherNames":20},"high-dose RT",[9],[25],{"name":26,"affiliation":27,"role":28},"Wei Liu, MD, FRCPC","BC Cancer - Vancouver","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":20,"email":34},"Amanda Clarke","CONTACT","6048776000","aclarke-02@bccancer.bc.ca",[36],{"facility":27,"status":20,"city":37,"state":38,"zip":20,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Vancouver","British Columbia","Canada","CA",{"type":42,"coordinates":43},"Point",[44,45],-123.11934,49.24966,{"lat":45,"lon":44},[48],{"name":49,"role":32,"phone":33,"phoneExt":20,"email":50},"Sandy Chang","sandy.chang@bccancer.bc.ca",{"type":52,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100615383","high-dose-radiotherapy-for-palliation-hi-d-100615383",false,"NCT07291895","High Dose Radiotherapy for Palliation (Hi-D)","A Prospective Study of High Dose Radiotherapy for Palliation: Hi-D","5.1. Inclusion Criteria\n\nSubjects must meet all of the following criteria to be eligible for participation in this study:\n\n* Age 18 or older.\n* Able to provide informed consent\n* Patient has histologically confirmed solid tumour malignancy\n* ECOG performance status 0 - 2\n* Life Expectancy \\> 6 months\n* Locally advanced or metastatic disease with 1-3 target lesions larger than 5cm in minimum dimension, with no more than 2 target lesions in a single organ; patients can have any number of non-target lesions\n* A history and physical exam, including ECOG performance status, performed within 6 weeks prior to trial enrollment\n* Not suitable for or declined curative-intent treatment\n* Subject has had a CT chest, abdomen and pelvis or PET-CT within 8 weeks prior to enrollment, and with 12 weeks of treatment\n* MRI spine for patients receiving RT to vertebral or paraspinal metastases\n* Patient is judged able to:\n* Maintain a stable position during therapy\n* Tolerate immobilization device(s) that may be required to deliver radiation safely\n\n5.2. Exclusion Criteria\n\nSubjects are excluded from the study if any of the following criteria apply:\n\n* Hematologic malignancy\n* Disease limited to intracranial sites\n* Serious medical co-morbidities precluding radiotherapy\n* Prior radiation to target lesion that precludes delivery of repeat radiation. All such cases should be discussed with the local and study PIs.\n* Pregnant people","ALL","18 Years",{"count":63,"type":64},21,"ESTIMATED","INTERVENTIONAL",[67],"NA","Palliative radiation is effective for controlling or preventing symptoms such as pain, bleeding, dyspnea, and cord compression. Recently, studies have shown that additional dose escalation may result in superior local control. The investigators propose a phase II single arm trial to evaluate a novel high-dose radiation regimen, which will be 27 Gray in 3 fractions with dose escalation within the tumour (Hi-D).",[70,17],"Metastases","NOT_YET_RECRUITING","2026-08-10",{"date":74,"type":75},"2026-08-12","ACTUAL",{"date":77,"type":64},"2027-03-01",{"date":79,"type":64},"2030-08-31",{"name":5,"class":6},1]