[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652298":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":26,"locations":32,"responsibleParty":47,"collaborators":11,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":11,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":74,"whyStopped":11,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Hacettepe University","OTHER",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Mild Disability Group (EDSS 0 to \u003C=2.5)","EXPERIMENTAL",null,[13],"Behavioral: High-Intensity Interval Training",{"label":15,"type":10,"description":11,"interventionNames":16},"Moderate Disability Group (EDSS 3.0 to \u003C=4.5)",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Severe Disability Group (EDSS 5.0 to \u003C=6.5)",[13],[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"BEHAVIORAL","High-Intensity Interval Training","All exercise sessions in our study will be conducted using a bicycle ergometer (Monark Cardio Care 827 X, Monark Exercise AB, Sweden). The HIIT protocol will consist of five 3-minute high-intensity intervals performed at 80-100 revolutions per minute, corresponding to 85-90% of maximum heart rate. Between these intervals, active rest periods will be implemented, during which cadence is reduced to 50-60 revolutions per minute for 1.5 minutes to lower heart rate to 50-60% of maximum heart rate. The total training duration is planned to be 20 minutes, consisting of a 2-minute warm-up at the beginning and a 2-minute cool-down at the end. Sessions will be conducted three times a week. The total treatment duration is planned to be 8 weeks.",[9,15,18],[27],{"name":28,"role":29,"phone":30,"phoneExt":11,"email":31},"İSMAİL KARA, MSc","CONTACT","+90 553 525 8700","ismailkaraa46@gmail.com",[33],{"facility":34,"status":11,"city":35,"state":11,"zip":11,"country":36,"countryCode":11,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Hatay Mustafa Kemal Universty","Hatay","Turkey (Türkiye)",{"type":38,"coordinates":39},"Point",[40,41],27.10486,38.40227,{"lat":41,"lon":40},[44],{"name":45,"role":29,"phone":11,"phoneExt":11,"email":46},"Yasemin Karaaslan, Phd","ptyasemindeveci@gmail.com",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","ISMAIL KARA","Research Assistant","100652298","high-intensity-interval-training-for-walking-and-function-across-different-multiple-sclerosis-disability-levels-100652298",false,"NCT07771868","High-Intensity Interval Training for Walking and Function Across Different Multiple Sclerosis Disability Levels","The Effect of High-Intensity Interval Training on Maximum Walking Distance and Functional Parameters in Patients With Multiple Sclerosis at Different Disability Levels","Inclusion Criteria:\n\n* Be between the ages of 18 and 65,\n* Have been diagnosed with MS by a treating physician,\n* Have an EDSS score between 0 and 6.5,\n* Not having experienced a relapse within the last 3 months,\n* Not having severe lower extremity contractures, severe spasticity (≥3 on the Modified Ashworth Scale), or an acute orthopedic problem that would prevent the participant from pedaling on a bicycle ergometer,\n* Having a Mini Mental State Examination score of ≥24.\n\nExclusion Criteria:\n\n* Having a severe cardiovascular, orthopedic, respiratory, or metabolic disease,\n* Having an additional neurological condition,\n* Being pregnant or suspecting pregnancy,\n* Having received a botulinum toxin injection within the last 3 months,\n* Having a COMPASS-31 total score greater than 13.6","ALL","18 Years","65 Years",{"count":62,"type":63},30,"ESTIMATED","INTERVENTIONAL",[66],"NA","Multiple Sclerosis (MS) is a chronic neurological disease that can affect daily functioning, mobility, and overall quality of life. High-Intensity Interval Training (HIIT) is known to be a time-efficient exercise approach that improves exercise capacity and reduces fatigue in MS. However, current research lacks sufficient data on how HIIT affects individuals with different levels of disability.\n\nThe main purpose of this study is to evaluate the effects of a stationary bicycle-based HIIT protocol on maximum walking distance, fatigue, balance, muscle strength, endurance, gait speed, and quality of life in MS patients across three different disability levels: mild, moderate, and severe (classified according to Expanded Disability Status Scale - EDSS scores).\n\nParticipants will complete a cycle ergometer-based HIIT program. Assessments will be conducted at three time points:\n\nBefore starting the exercise program (baseline)\n\nImmediately after completing the program (post-treatment)\n\n4 weeks after the completion of the program (follow-up)\n\nTo ensure unbiased results, a triple-blind design will be used, meaning the outcome assessor, the treating physiotherapist, and the data analyst will be blinded to group assignments. The findings aim to help clinicians tailor personalized, effective HIIT protocols based on a patient's specific disability level rather than using a standardized, one-size-fits-all approach in MS rehabilitation.",[69],"MULTIPL SCLEROSİS",[71,23,72,73],"Multiple Sclerosis","Cycle Ergometer","Expanded Disability Status Scale","NOT_YET_RECRUITING","2026-08-14",{"date":77,"type":78},"2026-08-18","ACTUAL",{"date":80,"type":63},"2026-08-17",{"date":82,"type":63},"2028-01-31",{"name":5,"class":6},1]