[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649399":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":42,"centralContacts":43,"locations":49,"responsibleParty":72,"collaborators":42,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":42,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":42,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":104,"whyStopped":42,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Iuliu Hatieganu University of Medicine and Pharmacy","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Intensity Laser Therapy + Physiotherapy","EXPERIMENTAL","Participants receive a standardised physiotherapy programme plus active high-intensity laser therapy (HILT). HILT is pulsed near-infrared laser, 7 W, 5 J\u002Fcm², applied over the lumbar spine (L1-L5) with a scanning handpiece for about 150 seconds per session, three sessions per week for four weeks (12 sessions total).",[13,14],"Device: High-Intensity Laser Therapy","Behavioral: Standardised Physiotherapy Programme",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham Laser + Physiotherapy","SHAM_COMPARATOR","Participants receive the same standardised physiotherapy programme plus a sham laser. The sham device looks and operates identically to the active laser but delivers no therapeutic energy. It follows the same schedule: about 150 seconds per session over the lumbar spine (L1-L5), three sessions per week for four weeks (12 sessions total).",[20,14],"Device: Sham Laser",[22,29,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","High-Intensity Laser Therapy","Pulsed near-infrared laser, 7 W, 5 J\u002Fcm², applied over the lumbar spine (L1-L5) with a scanning handpiece for about 150 seconds per session, three sessions per week for four weeks (12 sessions total). Delivered in the experimental arm only.",[9],[28],"HILT",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Sham Laser","A sham device identical in appearance and operation to the active laser but delivering no therapeutic energy. Applied on the same schedule: about 150 seconds per session over the lumbar spine (L1-L5), three sessions per week for four weeks. Delivered in the control arm only, to preserve blinding",[16],[34],"Placebo laser",{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"BEHAVIORAL","Standardised Physiotherapy Programme","A standardised physiotherapy (exercise) programme delivered identically in both arms as a background co-intervention. The programme is the same in content, frequency and duration for all participants, so the comparison isolates the added effect of the active laser versus sham.",[9,16],[41],"Kinesiotherapy",null,[44],{"name":45,"role":46,"phone":47,"phoneExt":42,"email":48},"Titus Vari, MD","CONTACT","+40 743 081 588","titus.vari@elearn.umfcluj.ro",[50],{"facility":51,"status":42,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Clinical Rehabilitation Hospital","Cluj-Napoca","Cluj","400347","Romania","RO",{"type":58,"coordinates":59},"Point",[60,61],23.6,46.76667,{"lat":61,"lon":60},[64,68,70],{"name":65,"role":46,"phone":66,"phoneExt":42,"email":67},"Viorela Mihaela Ciortea, MD, PhD","+40 264 207 021","viorela.ciortea@umfcluj.ro",{"name":45,"role":69,"phone":42,"phoneExt":42,"email":42},"PRINCIPAL_INVESTIGATOR",{"name":65,"role":71,"phone":42,"phoneExt":42,"email":42},"SUB_INVESTIGATOR",{"type":69,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Viorela Mihaela Ciortea","Conf. Dr. Viorela Mihaela Ciortea","100649399","high-intensity-laser-therapy-and-physiotherapy-for-bone-health-in-postmenopausal-women-a-randomized-trial-100649399",false,"NCT07734922","High-Intensity Laser Therapy and Physiotherapy for Bone Health in Postmenopausal Women: A Randomized Trial","The Effects of High-Intensity Laser Therapy Combined With Physiotherapy on Bone Turnover and Bone Mineral Density in Postmenopausal Women With Osteopenia or Osteoporosis: A Randomized Controlled Trial","Inclusion Criteria:\n\nPostmenopausal women Osteopenia or osteoporosis diagnosed by DXA (T-score below -1.0) Age 50 to 70 years Body mass index (BMI) between 18.5 and 30 Provides written informed consent\n\nExclusion Criteria:\n\nHistory of fractures Use of agents that may interfere with bone metabolism (e.g., bisphosphonates, glucocorticoids, hormone therapy) Severe comorbidities or decompensation of pre-existing conditions Recent physiotherapy (within the past 3 months) Rheumatologic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) High-dose calcium or vitamin D supplementation Contraindications to laser therapy (cancer, active bleeding or bleeding disorders, acute infections, photosensitivity, pregnancy, implanted electronic devices, or other conditions that could interfere with laser treatment)","FEMALE","50 Years","70 Years",{"count":86,"type":87},40,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this clinical trial is to learn if adding high-intensity laser therapy (HILT) to a physiotherapy programme helps bone health in women after menopause who have low bone density (osteopenia or osteoporosis). It also looks at safety and quality of life.\n\nThe main questions it aims to answer are:\n\nDoes adding high-intensity laser therapy change a blood marker of bone formation called P1NP? Does adding high-intensity laser therapy improve participants' quality of life? Researchers will compare a group that gets physiotherapy plus real laser therapy with a group that gets physiotherapy plus a sham laser (a look-alike treatment that gives no real laser energy). This shows if the laser itself makes a difference.\n\nParticipants will:\n\nDo the same physiotherapy programme, 3 times a week for 4 weeks Get either real or sham laser therapy at each session Give blood samples before and after treatment to measure the bone marker Fill in two quality-of-life questionnaires before and after treatment Have one bone density scan (DXA) at the start to check they can take part",[93,94],"Osteoporosis, Postmenopausal","Osteopenia",[24,96,97,98,99,100,101,102,103],"Laser Therapy","Exercise Therapy","Physical Therapy Modalities","Bone Remodeling","Bone Density","Procollagen Type I N-Terminal Propeptide","Menopause","Quality of Life","NOT_YET_RECRUITING","2026-07-24",{"date":107,"type":108},"2026-07-29","ACTUAL",{"date":110,"type":87},"2026-07-27",{"date":112,"type":87},"2027-02-28",{"name":5,"class":6},1]