[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652246":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":27,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":27,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":27,"enrollmentInfo":64,"targetDuration":27,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":36,"whyStopped":27,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Shanghai University of Sport","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TIs Arm","EXPERIMENTAL","Participants receive a single 20-minute session of active 40 Hz temporal interference stimulation (TIS) targeting the left hippocampus. In this randomized crossover design, each participant also undergoes a sham session on a separate visit, with at least 7 days between sessions. Memory, dual-task postural control, and fMRI assessments are conducted before and after each session.",[13],"Device: Temporal Interference Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"sham group","SHAM_COMPARATOR","Participants receive a single 20-minute session of sham TIS using identical electrode placement and setup, but without effective 40 Hz stimulation. In this randomized crossover design, each participant also undergoes an active TIS session on a separate visit, with at least 7 days between sessions. Memory, dual-task postural control, and fMRI assessments are conducted before and after each session.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Temporal Interference Stimulation","Transcranial temporal interference stimulation (TIS) is a noninvasive brain stimulation technique. In this randomized crossover trial, each participant receives two sessions in random order: one active 40 Hz TIS session targeting the left hippocampus and one sham session, with at least 7 days between sessions. Each session lasts 20 minutes. Outcome measures include memory tests, dual-task postural control assessments, and fMRI scans, conducted before and immediately after each session.",[9,15],[26],"TIs",null,[29],{"name":30,"role":31,"phone":32,"phoneExt":27,"email":33},"Jiaojiao Lü, PhD","CONTACT","+86 18516565889","ljj27@163.com",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Shanghai","Shanghai Municipality","200438","China","CN",{"type":43,"coordinates":44},"Point",[45,46],121.45806,31.22222,{"lat":46,"lon":45},[49],{"name":50,"role":31,"phone":51,"phoneExt":27,"email":52},"Ethics Committee of the Shanghai University of Sport","+86 21 65508179","lunli@sus.edu.cn",{"type":54,"investigatorFullName":30,"investigatorTitle":5,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","100652246","hippocampal-temporal-interference-stimulation-for-memory-and-dual-task-postural-control-in-older-adults-with-mild-cognitive-impairment-100652246",false,"NCT07771036","Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment","Effects and Underlying Mechanisms of Hippocampal-Targeted Temporal Interference Stimulation on Memory Function and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment","1. Aged 65 years or older;\n2. Presence of subjective memory complaints;\n3. Objective cognitive impairment: screened using the Montreal Cognitive Assessment-Bejingversion (MoCA-BJ). The MoCA-BJ total score is 30 points. For individuals with \\\u003C12 years ofeducation, 1 point is added to the raw total score (corrected total score capped at 30 points); acorrected total score \\\u003C26 points indicates risk of cognitive impairment;\n4. Clinical Dementia Rating (CDR) score of 0.5;\n5. Does not meet diagnostic criteria for dementia: Mini-Mental State Examination (MMSE) scores\\>18 for illiterate individuals, 221 for those with primary school education, and \\>25 for those withjunior high school education or above;6. Retains independent activities of daily living (ADL) and is capable of cooperating with allassessments and interventions.","ALL","65 Years",{"count":65,"type":66},21,"ESTIMATED","INTERVENTIONAL",[69],"NA","This trial aims to investigate whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory function and dual-task postural control among older adults with mild cognitive impairment (MCI). The primary research questions to be addressed are as follows:\n\n* Can 40 Hz hippocampal temporal interference stimulation boost memory test performance in older adults with MCI?\n* Can 40 Hz hippocampal temporal interference stimulation improve walking and balance ability under dual-task conditions in older adults with MCI? Researchers will compare active 40 Hz hippocampal temporal interference stimulation against sham stimulation to identify whether this intervention yields positive immediate effects on memory function and dual-task postural control.\n\nParticipants will be required to:\n\n* Attend three laboratory visits over approximately three weeks, and receive one session of active stimulation and one session of sham stimulation in random order, with an interval of at least seven days between the two stimulation visits;\n* Complete memory and motor function assessments before and after each stimulation session;\n* Undergo functional magnetic resonance imaging (fMRI) scans to detect changes in brain activity.",[72],"Mild Cognitive Impairment (MCI)",[74,22,26],"Mild Cognitive Impairment","2026-08-13",{"date":77,"type":78},"2026-08-18","ACTUAL",{"date":80,"type":78},"2026-07-30",{"date":82,"type":66},"2027-07-30",{"name":5,"class":6},1]