[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648371":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":32,"responsibleParty":52,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":25,"enrollmentInfo":63,"targetDuration":25,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":35,"whyStopped":25,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"psoriatic rheumatism patient","EXPERIMENTAL","patients with psoriatic arthritis",[13],"Biological: blood test",{"label":15,"type":16,"description":17,"interventionNames":18},"healthy group","ACTIVE_COMPARATOR","patients without inflammatory disease",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","blood test","Addition of an extra tube for blood tests (a single tube for genetic research), enabling phenotyping of the HLA B27 and HLA B leader genes.",[15,9],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Vincent Goeb, Pr","CONTACT","33+3.22.08.83.71","Goeb.vincent@chu-amiens.fr",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"CHU Amiens Picardie","RECRUITING","Amiens","Picardie","80054","France","FR",{"type":42,"coordinates":43},"Point",[44,45],2.3,49.9,{"lat":45,"lon":44},[48],{"name":49,"role":29,"phone":50,"phoneExt":25,"email":51},"Vincent GOEB, Pr","+33322668259","goeb.vincent@chu-amiens.fr",{"type":53,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100648371","hla-b-leader-in-patients-with-psoriatic-arthritis-100648371",false,"NCT07718815","HLA B Leader in Patients With Psoriatic Arthritis","HLABLRP","Inclusion Criteria:\n\n* For the \"Patient\" group:\n* Patient over 18 years of age\n* Patient affiliated to a social security scheme\n* Patient with psoriatic arthritis according to the CASPAR 2006 classification, followed at the CHU Amiens-Picardie.\n* For the \"control\" group:\n* Individuals over 18 years of age\n* Individual affiliated to a social security scheme\n* Individual having agreed to participate in the study\n* Individuals with no inflammatory or autoimmune diseases\n\nExclusion Criteria:\n\n* Patient or control not understanding French\n* Patient not included in the Amiens Picardie University Hospital's \"Psoriatic Rheumatism\" cohort, or control not included in the Amiens Picardie University Hospital's bone marrow donor cohort.\n* Patient or control objecting to participation in the study","ALL","18 Years",{"count":64,"type":65},658,"ESTIMATED","INTERVENTIONAL",[68],"NA","Psoriatic arthritis (PsA), a chronic immune-mediated heterogeneous inflammatory disease characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis and dactylitis), usually occurs in patients with psoriasis. The spondyloarthritides (SPs) (of which psoriasis is one) are a group of inflammatory diseases that share an association with the HLA-B27 MHC class I molecule.\n\nGiven this association, these diseases are classically regarded as disorders of adaptive immunity.\n\nIn bone marrow donation, HLA-B exon 1 dimorphism (HLAB leader) is associated with risk of graft- versus-host disease, relapse and overall survival after unrelated hematopoietic cell transplantation (UHCT), haploidentical UHCT and cord transplantation. In the literature, there are no studies suggesting the involvement of the HLA B leader gene in MS and RPs. The main aim of this study is to compare the presence of the HLA B leader gene between a group of patients with psoriatic arthritis and a healthy group without inflammatory disease.",[71,72,73],"Psoriatic Arthritis","HLA b Leader","HLA B27",[75,76,73],"Psoriatic arthritis","HLA b leader","2026-07-16",{"date":79,"type":80},"2026-07-22","ACTUAL",{"date":82,"type":80},"2025-05-06",{"date":84,"type":65},"2026-09",{"name":5,"class":6},1]