[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647850":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":61,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Orivian inc","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HME","EXPERIMENTAL","HME (powder plus slow-release tablet\u002Fcapsule together) at its licensed dose, once daily for 10 weeks. Taken post-workout on training days and in the morning on rest days.",[13],"Dietary Supplement: HME (Human Muscle Equivalent)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Maltodextrin powder and one maltodextrin capsule, matched to HME for appearance, volume, and taste; identical timing and instructions.",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","HME (Human Muscle Equivalent)","HME (Human Muscle Equivalent) is a two-component amino acid formulation taken together as a single daily serving: a 3 g free-form amino acid powder matched to the human skeletal muscle amino acid profile, plus a slow-release capsule containing 50 mg beta-alanine. Both components together constitute HME. Health Canada NPN 80148183 (powder) and 80148185 (capsule).",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Maltodextrin powder and capsule matched for appearance, volume, and taste.",[15],[31,34],{"name":32,"affiliation":5,"role":33},"Reza Ardekani, MD PhD","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":33},"Anthony Galea, MD","The Institute of Human Mechanics",[38],{"name":39,"role":40,"phone":41,"phoneExt":26,"email":42},"Reza Ardekani, MD","CONTACT","+1(647)468-2225","reza.ardekani.md@gmail.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"The Institute of Human Mechanics\u002F JUNXION Performance","RECRUITING","Toronto","Ontario","M8Z 2R4","Canada","CA",{"type":53,"coordinates":54},"Point",[55,56],-79.39864,43.70643,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":41,"phoneExt":26,"email":42},"Reza Ardekani",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100647850","hme-amino-acid-supplementation-for-strength-performance-and-recovery-in-trained-adult-males-100647850",false,"NCT07715201","HME Amino Acid Supplementation for Strength, Performance, and Recovery in Trained Adult Males","A Pilot Randomized, Double-Blind, Placebo-Controlled Trial of HME (Human Muscle Equivalent) Supplementation on Strength, Body Composition, Athletic Performance, and Recovery in Trained Adults","Inclusion Criteria:\n\n* Age 18 to 45 years inclusive\n* Biological male\n* Active competitive athlete in a recognized sport OR certified fitness professional (personal trainer, strength and conditioning coach, or equivalent)\n* Minimum 3 structured resistance-training sessions per week for at least 1 year continuously\n* Habitual protein intake 1.2 to 2.0 g\u002Fkg\u002Fday confirmed by 7-day food diary at screening\n* Current creatine users willing to use study-provided creatine monohydrate 5 g\u002Fday; non-users willing not to initiate creatine during the trial\n* Able to provide written informed consent in English\n* Willing and able to attend all supervised training sessions and assessment visits for 10 weeks\n* Access to a digital kitchen scale or willing to obtain one for food-record completion\n\nExclusion Criteria:\n\n* Use of anabolic steroids, SARMs, prohormones, or beta-alanine supplements (other than the study product) within 8 weeks of screening\n* Current use of any amino acid supplement or weight-gainer product not cleared by the research coordinator\n* Currently in an active competitive season with non-negotiable training demands the investigator determines are incompatible with the supervised programme\n* Musculoskeletal injury in the preceding 3 months affecting ability to perform study assessments or training\n* Any medical condition, medication, or dietary restriction that in the Medical Officer's opinion would affect the safety or validity of participation\n* Participation in another intervention study within 4 weeks of screening\n* Unwillingness to standardize creatine intake per protocol (current users) or to abstain from initiating creatine (non-users)",true,"MALE","18 Years","45 Years",{"count":75,"type":76},50,"ESTIMATED","INTERVENTIONAL",[79],"NA","This pilot randomized controlled trial evaluates HME (Human Muscle Equivalent), a free-form amino acid supplement formulated to match the amino acid composition of human skeletal muscle, taken at its Health Canada licensed dose (3 g powder plus one 50 mg slow-release beta-alanine capsule daily). Trained adult males (competitive athletes or certified fitness professionals) are randomized to HME or an identical-appearing placebo for 10 weeks: a 2-week supplement-only lead-in followed by 8 weeks of supplement plus supervised resistance training. The primary aim is to estimate the effect of HME on composite maximal strength (1-repetition maximum leg press plus chest press) compared with placebo. Secondary measures include isometric knee-extension strength, countermovement jump height, and subjective recovery.",[82,83,84],"Muscle Strength","Athletic Performance","Resistance Training",[86,87,88,9,89,90,91,92],"amino acids","human muscle equivalent","dietary supplement","body composition","recovery","sports nutrition","1-RM","2026-07-21",{"date":95,"type":96},"2026-07-23","ACTUAL",{"date":98,"type":96},"2026-06-29",{"date":100,"type":76},"2027-03-30",{"name":5,"class":6},1]