[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649276":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":69,"collaborators":71,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":101,"whyStopped":25,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Fondazione Don Carlo Gnocchi ETS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HOME-EXER: Motor-cognitive home-based telerehabilitation","EXPERIMENTAL","Participants will receive a home-based motor-cognitive telerehabilitation program delivered through the Homing system (Tecnobody, Italy). The intervention consists of combined motor and cognitive exergames with real-time visual and auditory feedback, aimed at improving cognitive-motor integration during activities that simulate daily living tasks. The program includes 20 sessions (45 minutes per session) over 7 weeks (three sessions per week), consisting of one remotely supervised synchronous session and two self-administered asynchronous sessions per week. Training difficulty and exercise content may be remotely adjusted by the clinical team according to the participant's performance and rehabilitation needs.",[13],"Other: HOME-EXER telerehabilitation protocol",{"label":15,"type":16,"description":17,"interventionNames":18},"OUT-REHAB: Multidisciplinary Outpatient Rehabilitation","ACTIVE_COMPARATOR","Participants will receive conventional multidisciplinary outpatient rehabilitation (usual care) following discharge from intensive inpatient neurorehabilitation. The program consists of individualized motor rehabilitation, cognitive rehabilitation, and occupational therapy delivered by qualified healthcare professionals. Treatment includes 20 sessions (45 minutes\u002Fsession) over 7 weeks (three sessions per week), with rehabilitation activities tailored to each participant's clinical needs according to standard clinical practice.",[19],"Other: OUT-REHAB rehabilitation protocol",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"HOME-EXER telerehabilitation protocol","Participants will follow the HOME-EXER telerehabilitation protocol",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"OUT-REHAB rehabilitation protocol","Participants will follow the OUT-REHAB rehabilitation protocol",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Ilaria Carpinella","CONTACT","+390240308315","icarpinella@dongnocchi.it",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":38},"Angela Comanducci","acomanducci@dongnocchi.it",[40,59],{"facility":41,"status":25,"city":42,"state":43,"zip":44,"country":43,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Istituto Auxologico Italiano IRCCS","Milan","Italy","20122","IT",{"type":47,"coordinates":48},"Point",[49,50],9.18951,45.46427,{"lat":50,"lon":49},[53,57],{"name":54,"role":33,"phone":55,"phoneExt":25,"email":56},"Antonio Caronni","+393887770233","antonio.caronni@unimi.it",{"name":54,"role":58,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"facility":60,"status":25,"city":42,"state":43,"zip":61,"country":43,"countryCode":45,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"IRCCS Fondazione Don Carlo Gnocchi ETS","20148",{"type":47,"coordinates":63},[49,50],{"lat":50,"lon":49},[66,67,68],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":37,"role":33,"phone":25,"phoneExt":25,"email":38},{"name":32,"role":58,"phone":25,"phoneExt":25,"email":25},{"type":58,"investigatorFullName":32,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Principal Investigator",[72],{"name":73,"class":6},"Istituto Auxologico Italiano","100649276","home-based-exergame-motor-cognitive-rehabilitation-for-traumatic-brain-injury-100649276",false,"NCT07733336","Home-Based Exergame Motor-Cognitive Rehabilitation for Traumatic Brain Injury","Effectiveness of Home-Based Exergame Motor-Cognitive Rehabilitation Versus Outpatient Multidisciplinary Rehabilitation in Individuals With Traumatic Brain Injury: A Pilot Controlled Trial","HOME-TBI","TBI patients Inclusion Criteria\n\n* Discharge from intensive inpatient post-acute rehabilitation following a first traumatic brain injury (TBI).\n* Level of Cognitive Functioning Scale (LCF) score ≥ 6, indicating appropriate and goal-directed cognitive responses.\n* Ability to walk at least 30 meters, with or without an assistive device.\n* Ability to maintain an unsupported standing position for at least 3 minutes.\n* Provision of written informed consent.\n\nTBI patients Exclusion Criteria\n\n* Diagnosis or suspected diagnosis of a neurodegenerative disorder.\n* Previous history of traumatic brain injury.\n* History of major psychiatric disorders (e.g., schizophrenia or bipolar disorder), primary sleep disorders, or epilepsy.\n* Severe visual or auditory impairment that could interfere with study assessments or participation in the rehabilitation program.\n* Severe expressive and\u002For receptive aphasia.\n* Language barriers preventing reliable cognitive assessment or informed consent procedures.\n* Current pregnancy.\n\nHealthy Subjects - Exclusion Criteria\n\n* Presence of any neurological, sensrory, cognitive, psychiatric, cardiopulmonary, or musculoskeletal condition that may affect study participation or outcome measures\n* Language barriers preventing reliable cognitive assessment or informed consent procedures.\n* Current pregnancy.",true,"ALL","18 Years","75 Years",{"count":87,"type":88},30,"ESTIMATED","INTERVENTIONAL",[91],"NA","The goal of this clinical trial is to evaluate the effectiveness of a home-based cognitive-motor telerehabilitation program in individuals with traumatic brain injury (TBI) following discharge from intensive inpatient neurorehabilitation.\n\nThe main questions it aims to answer are:\n\n* Does home-based cognitive-motor telerehabilitation improve functional independence, cognitive performance, mobility, and quality of life in individuals with TBI?\n* Are the effects of home-based cognitive-motor telerehabilitation superior to those achieved with standard outpatient rehabilitation?\n\nThe study will compare a home-based cognitive-motor telerehabilitation program with standard outpatient rehabilitation to determine their relative effects on functional recovery.\n\nParticipants will:\n\n* Receive either home-based cognitive-motor telerehabilitation or standard outpatient rehabilitation, according to the assigned treatment pathway. Both rehabilitation programs consist of 20 sessions lasting 45 minutes each, three times per week.\n* Undergo clinical, cognitive, and motor assessments at predefined study time points: T0 (hospital discharge, pre-intervention), T1 (post-intervention, 7 weeks after T0), and T2 (follow-up, 6 months after T0).\n* Be evaluated for changes in functional independence, cognitive functioning, mobility, quality of life, and caregiver burden.",[94],"Traumatic Brain Injury",[96,97,98,99,100],"Traumatic Brain Injury;","Telerehabilitation","motor function","cognitive function","multidisciplinary rehabilitation","NOT_YET_RECRUITING","2026-08-07",{"date":104,"type":105},"2026-08-11","ACTUAL",{"date":107,"type":88},"2026-11-03",{"date":109,"type":88},"2029-03-31",{"name":5,"class":6},2]