[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648151":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":47,"responsibleParty":60,"collaborators":25,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":25,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":89,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-Intensity (LI)","ACTIVE_COMPARATOR","The LI implementation approach will include providing sites with the HOPE Implementation Playbook, including access to the associated resources (e.g., OEND note templates) on the HOPE SharePoint site. Investigators will begin with an initial training session with each site, and lead a monthly learning collaborative for 6 months. The LI phase will allow evaluation of the effect of a comprehensive playbook on uptake of OEND.",[13],"Behavioral: Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity",{"label":15,"type":10,"description":16,"interventionNames":17},"High-Intensity (HI)","The HI approach will include: (1) creation of a novel clinical team (i.e., prescriber and HUD-VASH team) if not created under LI; (2) monthly overdose education and training delivered synchronously via Microsoft Teams; (3) monthly audit and feedback for each HUD-VASH team on progress toward providing OEND; and (4) technical assistance. Investigators hypothesize the HI implementation strategy will have a greater impact on RE-AIM outcomes.",[18],"Behavioral: Homeless Overdose Prevention- Expansion (HOPE) - High Intensity",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity","Homeless Overdose Prevention - Expansion (HOPE) tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in community-based supportive housing. During pre-implementation, investigators will conduct a rapid qualitative evaluation with 5-10 key informants at each of the identified implementation sites to refine the implementation approach. Investigators will evaluate low-intensity (LI) vs high-intensity (HI) strategy. The LI implementation approach will include providing sites with the HOPE Implementation Playbook, including access to the associated resources on the HOPE SharePoint site.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Homeless Overdose Prevention- Expansion (HOPE) - High Intensity","Homeless Overdose Prevention - Expansion (HOPE) tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in community-based supportive housing. During pre-implementation, investigators will conduct a rapid qualitative evaluation with 5-10 key informants at each of the identified implementation sites to refine the implementation approach. Investigators will evaluate low-intensity (LI) vs high-intensity (HI) strategy. The HI approach includes: (1) creation of a novel clinical team if not created under LI; (2) monthly overdose education and training delivered synchronously via Microsoft Teams; (3) monthly audit and feedback for each HUD-VASH team on progress toward providing OEND; and (4) technical assistance.",[15],[31],{"name":32,"affiliation":33,"role":34},"Amanda M. Midboe, PhD","VA Palo Alto Health Care System, Palo Alto, CA","PRINCIPAL_INVESTIGATOR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Amanda M Midboe, PhD","CONTACT","(650) 493-5000","27829","Amanda.Midboe@va.gov",{"name":43,"role":38,"phone":44,"phoneExt":45,"email":46},"Madeleine C Golding, MPH BA","(650) 614-9997","27422","madeleine.golding@va.gov",[48],{"facility":33,"status":25,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":25},"Palo Alto","California","94304-1207","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-122.14302,37.44188,{"lat":58,"lon":57},{"type":61,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100648151","homeless-overdose-prevention--expansion-100648151",false,"NCT07716202","Homeless Overdose Prevention- Expansion","Homeless Overdose Prevention- Expansion (HOPE) (QUE 25-014)","HOPE","Inclusion Criteria:\n\n* Veterans enrolled in HUD-VASH at risk for opioid overdose (based on existing HOPE algorithms aligned with Pharmacy Benefit Manager data definitions), drawing from VA administrative data.\n\nExclusion Criteria:\n\n* Not flagged by existing HOPE algorithms\n* Not currently enrolled in HUD-VASH\n* Is not a patient at a participating site of the implementation trial","ALL","18 Years",{"count":73,"type":74},1200,"ESTIMATED","INTERVENTIONAL",[77],"NA","Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in community-based supportive housing. HOPE sites will receive a playbook that offers step-by-step instructions, tools, templates, and checklists tailorable to site needs; sites will also receive performance feedback about their performance relative to a standard or benchmark.",[80,81,82],"Homelessness","Opioid Education and Naloxone Distribution (OEND)","Substance Use Disorder",[84,85,86,87,88],"Veterans","Risk Mitigation","Unstably Housed","Social Work","Implementation Science","NOT_YET_RECRUITING","2026-07-28",{"date":92,"type":93},"2026-07-30","ACTUAL",{"date":95,"type":74},"2026-08-31",{"date":97,"type":74},"2030-09-30",{"name":5,"class":6},1]